ENSMUSG00000020530


Mus musculus

Features
Gene ID: ENSMUSG00000020530
  
Biological name :Ggnbp2
  
Synonyms : Gametotin-binding protein 2 / Ggnbp2 / Q5SV77
  
Possible biological names infered from orthology : gametogenetin binding protein 2 / Q9H3C7
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: C
Gene start: 84832361
Gene end: 84870817
  
Corresponding Affymetrix probe sets: 10389308 (MoGene1.0st)   1426011_a_at (Mouse Genome 430 2.0 Array)   1440929_at (Mouse Genome 430 2.0 Array)   1459917_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000129898
Ensembl peptide - ENSMUSP00000129794
Ensembl peptide - ENSMUSP00000130013
Ensembl peptide - ENSMUSP00000018547
Ensembl peptide - ENSMUSP00000098252
Ensembl peptide - ENSMUSP00000103716
Ensembl peptide - ENSMUSP00000117482
Ensembl peptide - ENSMUSP00000127584
Ensembl peptide - ENSMUSP00000128109
NCBI entrez gene - 217039     See in Manteia.
MGI - MGI:2387356
RefSeq - XM_017314475
RefSeq - NM_153144
RefSeq - XM_011248933
RefSeq - XM_017314471
RefSeq - XM_017314472
RefSeq - XM_017314473
RefSeq - XM_017314474
RefSeq Peptide - NP_694784
swissprot - F6Y247
swissprot - H7BX83
swissprot - E9Q6H9
swissprot - E9Q389
swissprot - Q5SV77
Ensembl - ENSMUSG00000020530
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ggnbp2ENSDARG00000055086Danio rerio
 GGNBP2ENSGALG00000005397Gallus gallus
 GGNBP2ENSG00000278311Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026073  Gametogenetin-binding protein 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0030154 cell differentiation IDA
 biological_processGO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein IMP
 biological_processGO:0042532 negative regulation of tyrosine phosphorylation of STAT protein IMP
 biological_processGO:0060711 labyrinthine layer development IMP
 biological_processGO:0060716 labyrinthine layer blood vessel development IMP
 biological_processGO:0061099 negative regulation of protein tyrosine kinase activity IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gbx1tm1b(KOMP)Wtsi/Gbx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gbx1tm1b(KOMP)Wtsi/H

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
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Allelic Composition: Gbx1tm1b(KOMP)Wtsi/Gbx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gbx1tm1b(KOMP)Wtsi/H

Allelic Composition: Ggnbp2tm1b(KOMP)Wtsi/Ggnbp2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ggnbp2tm1b(KOMP)Wtsi/Tcp

 MP:0001539 decreased number of caudal vertebrae "reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gbx1tm1b(KOMP)Wtsi/Gbx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gbx1tm1b(KOMP)Wtsi/H

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Gbx1tm1b(KOMP)Wtsi/Gbx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gbx1tm1b(KOMP)Wtsi/H

Allelic Composition: Ggnbp2tm1b(KOMP)Wtsi/Ggnbp2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ggnbp2tm1b(KOMP)Wtsi/Tcp

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Olfr151tm37(Olfr16*,Gnas*)Mom/Olfr151+
Genetic Background: B6;129P2-Olfr151tm37(Olfr16*,Gnas*)Mom/MomJ

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gbx1tm1b(KOMP)Wtsi/Gbx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gbx1tm1b(KOMP)Wtsi/H

Allelic Composition: Ggnbp2tm1b(KOMP)Wtsi/Ggnbp2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ggnbp2tm1b(KOMP)Wtsi/Tcp

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gbx1tm1b(KOMP)Wtsi/Gbx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gbx1tm1b(KOMP)Wtsi/H

Allelic Composition: Ggnbp2tm1b(KOMP)Wtsi/Ggnbp2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ggnbp2tm1b(KOMP)Wtsi/Tcp

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Olfr151tm37(Olfr16*,Gnas*)Mom/Olfr151+
Genetic Background: B6;129P2-Olfr151tm37(Olfr16*,Gnas*)Mom/MomJ

 MP:0004266 pale placenta "placenta lacking normal reddish coloration, often refers to bloodless condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Olfr151tm37(Olfr16*,Gnas*)Mom/Olfr151+
Genetic Background: B6;129P2-Olfr151tm37(Olfr16*,Gnas*)Mom/MomJ

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gbx1tm1b(KOMP)Wtsi/Gbx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gbx1tm1b(KOMP)Wtsi/H

 MP:0005567 decreased circulating total protein level "less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
Show

Allelic Composition: Gbx1tm1b(KOMP)Wtsi/Gbx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Gbx1tm1b(KOMP)Wtsi/H

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Olfr151tm37(Olfr16*,Gnas*)Mom/Olfr151+
Genetic Background: B6;129P2-Olfr151tm37(Olfr16*,Gnas*)Mom/MomJ

 MP:0008957 abnormal placenta junctional zone morphology "fetally derived placental region that separates the maternal uterine tissue from the placenta labyrinth" [PMID:16367805]
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Allelic Composition: Olfr151tm37(Olfr16*,Gnas*)Mom/Olfr151+
Genetic Background: B6;129P2-Olfr151tm37(Olfr16*,Gnas*)Mom/MomJ

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Olfr151tm37(Olfr16*,Gnas*)Mom/Olfr151+
Genetic Background: B6;129P2-Olfr151tm37(Olfr16*,Gnas*)Mom/MomJ

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ggnbp2tm1b(KOMP)Wtsi/Ggnbp2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ggnbp2tm1b(KOMP)Wtsi/Tcp

 MP:0013294 prenatal lethality prior to heart atrial septation "death prior to the completion of heart atrial septation (Mus: E14.5-15.5)" [MGI:smb]
Show

Allelic Composition: Ggnbp2tm1b(KOMP)Wtsi/Ggnbp2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ggnbp2tm1b(KOMP)Wtsi/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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