ENSMUSG00000020638


Mus musculus

Features
Gene ID: ENSMUSG00000020638
  
Biological name :Cmpk2
  
Synonyms : Cmpk2 / Q3U5Q7 / UMP-CMP kinase 2, mitochondrial
  
Possible biological names infered from orthology : cytidine/uridine monophosphate kinase 2 / Q5EBM0
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: A2
Gene start: 26469204
Gene end: 26479837
  
Corresponding Affymetrix probe sets: 10395039 (MoGene1.0st)   1422095_a_at (Mouse Genome 430 2.0 Array)   1450484_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020969
NCBI entrez gene - 22169     See in Manteia.
MGI - MGI:99830
RefSeq - NM_020557
RefSeq Peptide - NP_065582
swissprot - Q3U5Q7
Ensembl - ENSMUSG00000020638
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cmpk2ENSDARG00000031359Danio rerio
 CMPK2ENSGALG00000028982Gallus gallus
 CMPK2ENSG00000134326Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR014505  UMP-CMP kinase, mitochondrai
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006165 nucleoside diphosphate phosphorylation IEA
 biological_processGO:0006221 pyrimidine nucleotide biosynthetic process IEA
 biological_processGO:0006227 dUDP biosynthetic process IEA
 biological_processGO:0006233 dTDP biosynthetic process IEA
 biological_processGO:0006235 dTTP biosynthetic process IBA
 biological_processGO:0009142 nucleoside triphosphate biosynthetic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005739 mitochondrion ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004127 cytidylate kinase activity ISO
 molecular_functionGO:0004550 nucleoside diphosphate kinase activity ISO
 molecular_functionGO:0004798 thymidylate kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0009041 uridylate kinase activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0033862 UMP kinase activity ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
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Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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