ENSMUSG00000020717


Mus musculus

Features
Gene ID: ENSMUSG00000020717
  
Biological name :Pecam1
  
Synonyms : Pecam1 / platelet/endothelial cell adhesion molecule 1 / Q08481
  
Possible biological names infered from orthology : platelet and endothelial cell adhesion molecule 1
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E1
Gene start: 106654217
Gene end: 106750628
  
Corresponding Affymetrix probe sets: 10392221 (MoGene1.0st)   1421287_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122414
Ensembl peptide - ENSMUSP00000102408
Ensembl peptide - ENSMUSP00000138959
Ensembl peptide - ENSMUSP00000067111
Ensembl peptide - ENSMUSP00000079664
Ensembl peptide - ENSMUSP00000099358
NCBI entrez gene - 18613     See in Manteia.
MGI - MGI:97537
RefSeq - XM_011248793
RefSeq - NM_001305157
RefSeq - NM_001305158
RefSeq - NM_008816
RefSeq - XM_006532472
RefSeq - XM_006532473
RefSeq - XM_006532474
RefSeq - XM_011248792
RefSeq - NM_001032378
RefSeq Peptide - NP_032842
RefSeq Peptide - NP_001027550
RefSeq Peptide - NP_001292086
RefSeq Peptide - NP_001292087
swissprot - Q08481
swissprot - B1ARB3
swissprot - B1ARA9
Ensembl - ENSMUSG00000020717
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pecam1ENSDARG00000060263Danio rerio
 si:dkey-237i9.8ENSDARG00000103020Danio rerio
 PECAM1ENSG00000261371Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001886 endothelial cell morphogenesis IMP
 biological_processGO:0006909 phagocytosis ISO
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules ISO
 biological_processGO:0007159 leukocyte cell-cell adhesion ISO
 biological_processGO:0007266 Rho protein signal transduction IMP
 biological_processGO:0030334 regulation of cell migration IMP
 biological_processGO:0042060 wound healing IMP
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IDA
 biological_processGO:0043542 endothelial cell migration IMP
 biological_processGO:0050904 diapedesis ISO
 biological_processGO:0072672 neutrophil extravasation ISO
 biological_processGO:0090673 endothelial cell-matrix adhesion IMP
 biological_processGO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules ISO
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030485 smooth muscle contractile fiber IDA
 cellular_componentGO:0045121 membrane raft IDA
 cellular_componentGO:0071944 cell periphery IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000532 kidney vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the organ of secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Foxp3tm1(CD2/CD52)Shori/Foxp3tm1(CD2/CD52)Shori
Genetic Background: involves: C57BL/6

 MP:0001613 abnormal vasodilation "anomalous widening of the lumen of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Stat1m2Btlr/Stat1m2Btlr
Genetic Background: C57BL/6J-Stat1m2Btlr

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Braftm1.1Sva/Braftm1.1Sva
Genetic Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ

 MP:0002933 joint inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the joints" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Braftm1.1Sva/Braftm1.1Sva
Genetic Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

 MP:0003303 peritoneal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the membrane that lines the abdominal cavity and covers most of the viscera" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Phox2atm1Jbr/Phox2atm1Jbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003724 susceptibility to induced arthritis "more likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Braftm1.1Sva/Braftm1.1Sva
Genetic Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ

Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

 MP:0003828 pulmonary edema "an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

 MP:0003957 abnormal nitric oxide homeostasis "anomaly in the state of equilibrium in the body of nitric oxide, a free radical gas and a potent vasodilator" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Stat1m2Btlr/Stat1m2Btlr
Genetic Background: C57BL/6J-Stat1m2Btlr

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mir133a-2tm1.1Eno/Mir133a-2tm1.1Eno
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0005591 decreased vasodilation "less than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Stat1m2Btlr/Stat1m2Btlr
Genetic Background: C57BL/6J-Stat1m2Btlr

Allelic Composition: Pecam1Gt(OST16303)Lex/Pecam1Gt(OST16303)Lex
Genetic Background: B6.129S-Pecam1Gt(OST16303)Lex/J

 MP:0006027 impaired alveologenesis "a block or reduction in the generation of alveoli" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]
Show

Allelic Composition: Foxp3tm1(CD2/CD52)Shori/Foxp3tm1(CD2/CD52)Shori
Genetic Background: involves: C57BL/6

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Braftm1.1Sva/Braftm1.1Sva
Genetic Background: involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ

 MP:0009864 abnormal aorta endothelium morphology "any strucutral anomaly of the thin layer of flat cells that line the aorta and form a barrier between circulating blood in the lumen and the rest of the vessel wall" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Pecam1Gt(OST16303)Lex/Pecam1Gt(OST16303)Lex
Genetic Background: B6.129-Apoetm1Unc Pecam1Gt(OST16303)Lex

 MP:0010018 lung vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

 MP:0010019 liver vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the liver" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

 MP:0010020 spleen vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the spleen" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

 MP:0010902 abnormal pulmonary alveolar sac morphology "any structural anomaly of the small terminal dilation of the alveolar ducts around which the alveoli form pocket-like clusters" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Foxp3tm1(CD2/CD52)Shori/Foxp3tm1(CD2/CD52)Shori
Genetic Background: involves: C57BL/6

 MP:0010903 abnormal pulmonary alveolus wall morphology 
Show

Allelic Composition: Foxp3tm1(CD2/CD52)Shori/Foxp3tm1(CD2/CD52)Shori
Genetic Background: involves: C57BL/6

 MP:0011134 decreased lung endothelial cell migration "reduced or slower movement of endothelial cells or their precursors to the appropriate location in the pulmonary vasculature" [MGI:csmith]
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Allelic Composition: Foxp3tm1(CD2/CD52)Shori/Foxp3tm1(CD2/CD52)Shori
Genetic Background: involves: C57BL/6

 MP:0011433 glomerular capillary congestion "obstruction of the normal flux of blood within the renal glomerular capillaries" [MGI:anna]
Show

Allelic Composition: Pecam1tm1Mak/Pecam1+
Genetic Background: D1.129P2-Pecam1tm1Mak

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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