ENSMUSG00000020801


Mus musculus

Features
Gene ID: ENSMUSG00000020801
  
Biological name :Med31
  
Synonyms : Med31 / Mediator of RNA polymerase II transcription subunit 31 / Q9CXU1
  
Possible biological names infered from orthology : mediator complex subunit 31 / Q9Y3C7
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B4
Gene start: 72211724
Gene end: 72215592
  
Corresponding Affymetrix probe sets: 10388154 (MoGene1.0st)   1417387_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021157
NCBI entrez gene - 67279     See in Manteia.
MGI - MGI:1914529
RefSeq - NM_026068
RefSeq Peptide - NP_080344
swissprot - Q9CXU1
Ensembl - ENSMUSG00000020801
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 med31ENSDARG00000008020Danio rerio
 MED31ENSGALG00000030401Gallus gallus
 MED31ENSG00000108590Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008831  Mediator complex, subunit Med31


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0048147 negative regulation of fibroblast proliferation IMP
 biological_processGO:0060173 limb development IMP
 cellular_componentGO:0000151 ubiquitin ligase complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0016592 mediator complex IDA
 cellular_componentGO:0070847 core mediator complex IBA
 molecular_functionGO:0003713 transcription coactivator activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA


Pathways (from Reactome)
Pathway description
Generic Transcription Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr3tm6.2Cxd/Fgfr3tm6.2Cxd
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgfr3tm6.2Cxd/Fgfr3tm6.2Cxd
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Erbb2l11Jus8/Erbb2l11Jus8
Genetic Background: Not Specified

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Erbb2l11Jus8/Erbb2l11Jus8
Genetic Background: Not Specified

Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002088 abnormal embryonic growth/weight/body size "limited or accelerated growth or development apparent before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Erbb2l11Jus8/Erbb2l11Jus8
Genetic Background: Not Specified

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Erbb2l11Jus8/Erbb2l11Jus8
Genetic Background: Not Specified

Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005352 small skull "less than the normal size of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0006279 abnormal limb development "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0010103 small thoracic cage "reduced size of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Erbb2l11Jus8/Erbb2l11Jus8
Genetic Background: Not Specified

Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0020040 decreased bone ossification "decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Med31l11Jus15/Med31l11Jus15
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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