ENSMUSG00000021054


Mus musculus

Features
Gene ID: ENSMUSG00000021054
  
Biological name :Sgpp1
  
Synonyms : Q9JI99 / Sgpp1 / sphingosine-1-phosphate phosphatase 1
  
Possible biological names infered from orthology : Q9BX95
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: C3
Gene start: 75714249
Gene end: 75735729
  
Corresponding Affymetrix probe sets: 10401028 (MoGene1.0st)   1420821_at (Mouse Genome 430 2.0 Array)   1420822_s_at (Mouse Genome 430 2.0 Array)   1450015_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151268
Ensembl peptide - ENSMUSP00000021450
NCBI entrez gene - 81535     See in Manteia.
MGI - MGI:2135760
RefSeq - NM_030750
RefSeq Peptide - NP_109675
swissprot - A0A1W2P6K9
swissprot - Q3UDY2
swissprot - Q9JI99
Ensembl - ENSMUSG00000021054
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sgpp1ENSDARG00000060534Danio rerio
 si:ch211-212g7.6ENSDARG00000079369Danio rerio
 SGPP1ENSGALG00000041183Gallus gallus
 SGPP1ENSG00000126821Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sgpp2 / Q810K3 / Sphingosine-1-phosphate phosphatase 2 / Q8IWX5*ENSMUSG0000003290833


Protein motifs (from Interpro)
Interpro ID Name
 IPR000326  Phosphatidic acid phosphatase type 2/haloperoxidase
 IPR036938  Phosphatidic acid phosphatase type 2/haloperoxidase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006665 sphingolipid metabolic process IDA
 biological_processGO:0006668 sphinganine-1-phosphate metabolic process IDA
 biological_processGO:0006670 sphingosine metabolic process IDA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IDA
 biological_processGO:0097193 intrinsic apoptotic signaling pathway IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042392 sphingosine-1-phosphate phosphatase activity IDA


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0002656 abnormal keratinocyte differentiation "developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0009474 thick epidermal spinous layer "increased thickness of the stratum spinosum; the polyhedral cell layer" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0009583 increased keratinocyte proliferation "increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0009599 thick epidermis stratum granulosum "increased thickness of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0009715 thick epidermis stratum basale "increased thickness of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0009931 abnormal skin appearance "skin that looks different from the usual state" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0012232 abnormal ceramide level 
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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