ENSMUSG00000021147


Mus musculus

Features
Gene ID: ENSMUSG00000021147
  
Biological name :Wdr37
  
Synonyms : Q8CBE3 / Wdr37 / WD repeat domain 37
  
Possible biological names infered from orthology : Q9Y2I8
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A1
Gene start: 8802968
Gene end: 8871909
  
Corresponding Affymetrix probe sets: 10407513 (MoGene1.0st)   1432615_at (Mouse Genome 430 2.0 Array)   1434076_at (Mouse Genome 430 2.0 Array)   1434077_at (Mouse Genome 430 2.0 Array)   1453024_at (Mouse Genome 430 2.0 Array)   1454823_at (Mouse Genome 430 2.0 Array)   1455278_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135785
Ensembl peptide - ENSMUSP00000021572
Ensembl peptide - ENSMUSP00000062174
Ensembl peptide - ENSMUSP00000131469
Ensembl peptide - ENSMUSP00000134916
Ensembl peptide - ENSMUSP00000134987
Ensembl peptide - ENSMUSP00000135094
Ensembl peptide - ENSMUSP00000135097
Ensembl peptide - ENSMUSP00000135101
Ensembl peptide - ENSMUSP00000135182
Ensembl peptide - ENSMUSP00000135271
Ensembl peptide - ENSMUSP00000135577
Ensembl peptide - ENSMUSP00000135742
NCBI entrez gene - 207615     See in Manteia.
MGI - MGI:1920393
RefSeq - XM_011244252
RefSeq - NM_001039388
RefSeq - NM_001039389
RefSeq - NM_172445
RefSeq - XM_006516469
RefSeq - XM_006516470
RefSeq - XM_006516471
RefSeq Peptide - NP_001034477
RefSeq Peptide - NP_001034478
RefSeq Peptide - NP_766033
swissprot - Q8CBE3
swissprot - H3BJB3
swissprot - H3BJR4
swissprot - H3BJR7
swissprot - H3BJS1
swissprot - H3BJZ0
swissprot - H3BK66
swissprot - H3BLH1
swissprot - H3BKY3
swissprot - H3BJH4
swissprot - Q05BF4
Ensembl - ENSMUSG00000021147
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wdr37ENSDARG00000074611Danio rerio
 WDR37ENSGALG00000006749Gallus gallus
 WDR37ENSG00000047056Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Copa / Q8CIE6 / Coatomer subunit alpha Xenin Proxenin / P53621* / coatomer protein complex subunit alpha*ENSMUSG0000002655321


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000460 maturation of 5.8S rRNA IBA
 biological_processGO:0000470 maturation of LSU-rRNA IBA
 cellular_componentGO:0030687 preribosome, large subunit precursor IBA
 cellular_componentGO:0070545 PeBoW complex IBA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Cbx5tm1a(EUCOMM)Wtsi/Cbx5tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cbx5tm1a(EUCOMM)Wtsi/Wtsi

 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cbx5tm1a(EUCOMM)Wtsi/Cbx5tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cbx5tm1a(EUCOMM)Wtsi/Wtsi

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cbx5tm1a(EUCOMM)Wtsi/Cbx5tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cbx5tm1a(EUCOMM)Wtsi/Wtsi

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cbx5tm1a(EUCOMM)Wtsi/Cbx5tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cbx5tm1a(EUCOMM)Wtsi/Wtsi

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Cbx5tm1a(EUCOMM)Wtsi/Cbx5tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cbx5tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002599 increased mean platelet volume "increased content of platelet cells over the norm" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]
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Allelic Composition: Cbx5tm1a(EUCOMM)Wtsi/Cbx5tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cbx5tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cbx5tm1a(EUCOMM)Wtsi/Cbx5tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cbx5tm1a(EUCOMM)Wtsi/Wtsi

 MP:0004174 abnormal spine curvature "deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cbx5tm1a(EUCOMM)Wtsi/Cbx5tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cbx5tm1a(EUCOMM)Wtsi/Wtsi

 MP:0004609 vertebral fusion "the union of one or more vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cbx5tm1a(EUCOMM)Wtsi/Cbx5tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cbx5tm1a(EUCOMM)Wtsi/Wtsi

 MP:0004613 fusion of vertebral arches "improper union of the dorsal part of adjacent vertebra" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cbx5tm1a(EUCOMM)Wtsi/Cbx5tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cbx5tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cbx5tm1a(EUCOMM)Wtsi/Cbx5tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cbx5tm1a(EUCOMM)Wtsi/Wtsi

 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Cbx5tm1a(EUCOMM)Wtsi/Cbx5tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cbx5tm1a(EUCOMM)Wtsi/Wtsi

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Cbx5tm1a(EUCOMM)Wtsi/Cbx5tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cbx5tm1a(EUCOMM)Wtsi/Wtsi

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cbx5tm1a(EUCOMM)Wtsi/Cbx5tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cbx5tm1a(EUCOMM)Wtsi/Wtsi

 MP:0010168 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number "a greater number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
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Allelic Composition: Cbx5tm1a(EUCOMM)Wtsi/Cbx5tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cbx5tm1a(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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