ENSMUSG00000021235


Mus musculus

Features
Gene ID: ENSMUSG00000021235
  
Biological name :Coq6
  
Synonyms : Coq6 / Q8R1S0 / Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
  
Possible biological names infered from orthology : coenzyme Q6, monooxygenase / Q9Y2Z9
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: D1
Gene start: 84361657
Gene end: 84373796
  
Corresponding Affymetrix probe sets: 10397216 (MoGene1.0st)   1426902_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000105907
Ensembl peptide - ENSMUSP00000117609
Ensembl peptide - ENSMUSP00000115676
Ensembl peptide - ENSMUSP00000021661
Ensembl peptide - ENSMUSP00000105905
NCBI entrez gene - 217707     See in Manteia.
MGI - MGI:1924408
RefSeq - XM_006515700
RefSeq - NM_172582
RefSeq - XM_006515699
RefSeq Peptide - NP_766170
swissprot - D6RG57
swissprot - Q8R1S0
swissprot - F6ZE40
swissprot - D3YW66
Ensembl - ENSMUSG00000021235
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 coq6ENSDARG00000060380Danio rerio
 COQ6ENSGALG00000010197Gallus gallus
 COQ6ENSG00000119723Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000689  Ubiquinone biosynthesis monooxygenase COQ6
 IPR002938  FAD-binding domain
 IPR010971  Ubiquinone biosynthesis hydroxylase UbiH/COQ6
 IPR018168  Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6, conserved site
 IPR036188  FAD/NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006744 ubiquinone biosynthetic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IEA
 molecular_functionGO:0071949 FAD binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001289 persistence of hyaloid capillary system "failure of the degeneration of the transient vascular system of the eye during development" [J:49840]
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Allelic Composition: Cbln3tm1.1(KOMP)Vlcg/Cbln3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cbln3tm1.1(KOMP)Vlcg/Ucd

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Col4a5tm1b(EUCOMM)Wtsi/Col4a5tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Col4a5tm1b(EUCOMM)Wtsi/Cnrm

Allelic Composition: Coq6tm1b(EUCOMM)Hmgu/Coq6+
Genetic Background: C57BL/6N-Coq6tm1b(EUCOMM)Hmgu/J

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col4a5tm1b(EUCOMM)Wtsi/Col4a5tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Col4a5tm1b(EUCOMM)Wtsi/Cnrm

Allelic Composition: Coq6tm1b(EUCOMM)Hmgu/Coq6+
Genetic Background: C57BL/6N-Coq6tm1b(EUCOMM)Hmgu/J

 MP:0002699 abnormal vitreous body "anomalies of the transparent, semigelatinous substance that fills the cavity behind the crystalline lens of the eye and in front of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cbln3tm1.1(KOMP)Vlcg/Cbln3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cbln3tm1.1(KOMP)Vlcg/Ucd

 MP:0002861 abnormal tail bud morphology "anomalous formation of the primordial region of the embryo that arises to form the tail of the adult; appears approximately ten days following conception as a short stump, and then initiates elongation and thinning in normal development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col4a5tm1b(EUCOMM)Wtsi/Col4a5tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Col4a5tm1b(EUCOMM)Wtsi/Cnrm

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
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Allelic Composition: Col4a5tm1b(EUCOMM)Wtsi/Col4a5tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Col4a5tm1b(EUCOMM)Wtsi/Cnrm

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col4a5tm1b(EUCOMM)Wtsi/Col4a5tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Col4a5tm1b(EUCOMM)Wtsi/Cnrm

Allelic Composition: Coq6tm1b(EUCOMM)Hmgu/Coq6+
Genetic Background: C57BL/6N-Coq6tm1b(EUCOMM)Hmgu/J

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Coq6tm1b(EUCOMM)Hmgu/Coq6+
Genetic Background: C57BL/6N-Coq6tm1b(EUCOMM)Hmgu/J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Cbln3tm1.1(KOMP)Vlcg/Cbln3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cbln3tm1.1(KOMP)Vlcg/Ucd

Allelic Composition: Coq6tm1b(EUCOMM)Hmgu/Coq6tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Coq6tm1b(EUCOMM)Hmgu/J

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Coq6tm1b(EUCOMM)Hmgu/Coq6tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Coq6tm1b(EUCOMM)Hmgu/J

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Coq6tm1b(EUCOMM)Hmgu/Coq6tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Coq6tm1b(EUCOMM)Hmgu/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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