ENSMUSG00000021236


Mus musculus

Features
Gene ID: ENSMUSG00000021236
  
Biological name :Entpd5
  
Synonyms : Ectonucleoside triphosphate diphosphohydrolase 5 / Entpd5 / Q9WUZ9
  
Possible biological names infered from orthology : O75356
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: D1
Gene start: 84373857
Gene end: 84409029
  
Corresponding Affymetrix probe sets: 10401454 (MoGene1.0st)   1417382_at (Mouse Genome 430 2.0 Array)   1417383_at (Mouse Genome 430 2.0 Array)   1417384_at (Mouse Genome 430 2.0 Array)   1433763_at (Mouse Genome 430 2.0 Array)   1451765_a_at (Mouse Genome 430 2.0 Array)   1458677_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021662
Ensembl peptide - ENSMUSP00000113106
Ensembl peptide - ENSMUSP00000114011
Ensembl peptide - ENSMUSP00000071939
Ensembl peptide - ENSMUSP00000105901
Ensembl peptide - ENSMUSP00000112516
NCBI entrez gene - 12499     See in Manteia.
MGI - MGI:1321385
RefSeq - NM_001286049
RefSeq - NM_001026214
RefSeq - NM_001286058
RefSeq - NM_007647
RefSeq Peptide - NP_001021385
RefSeq Peptide - NP_001272978
RefSeq Peptide - NP_001272987
RefSeq Peptide - NP_031673
swissprot - Q3TQC7
swissprot - Q9WUZ9
Ensembl - ENSMUSG00000021236
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 entpd5aENSDARG00000053481Danio rerio
 entpd5bENSDARG00000093659Danio rerio
 ENTPD5ENSGALG00000010202Gallus gallus
 ENTPD5ENSG00000187097Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Entpd6 / Mus musculus ectonucleoside triphosphate diphosphohydrolase 6 (Entpd6), transcript variant 2, mRNA. / O75354* / ectonucleoside triphosphate diphosphohydrolase 6 (putative)*ENSMUSG0000003306846


Protein motifs (from Interpro)
Interpro ID Name
 IPR000407  Nucleoside phosphatase GDA1/CD39


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0006487 protein N-linked glycosylation IMP
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0014066 regulation of phosphatidylinositol 3-kinase signaling IMP
 biological_processGO:0045821 positive regulation of glycolytic process IMP
 biological_processGO:0046034 ATP metabolic process IMP
 biological_processGO:0051084 "de novo" posttranslational protein folding IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004382 guanosine-diphosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017110 nucleoside-diphosphatase activity IEA
 molecular_functionGO:0045134 uridine-diphosphatase activity IEA


Pathways (from Reactome)
Pathway description
Phosphate bond hydrolysis by NTPDase proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Capn3tm1.1Hiso/Capn3tm1.1Hiso
Genetic Background: B6.129P2-Capn3tm1.1Hiso

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Capn3tm1.1Hiso/Capn3tm1.1Hiso
Genetic Background: B6.129P2-Capn3tm1.1Hiso

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Capn3tm1.1Hiso/Capn3tm1.1Hiso
Genetic Background: B6.129P2-Capn3tm1.1Hiso

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Capn3tm1.1Hiso/Capn3tm1.1Hiso
Genetic Background: B6.129P2-Capn3tm1.1Hiso

Allelic Composition: Entpd5m1Btlr/Entpd5m1Btlr
Genetic Background: C57BL/6J-Entpd5m1Btlr

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Capn3tm1.1Hiso/Capn3tm1.1Hiso
Genetic Background: B6.129P2-Capn3tm1.1Hiso

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Capn3tm1.1Hiso/Capn3tm1.1Hiso
Genetic Background: B6.129P2-Capn3tm1.1Hiso

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Capn3tm1.1Hiso/Capn3tm1.1Hiso
Genetic Background: B6.129P2-Capn3tm1.1Hiso

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Capn3tm1.1Hiso/Capn3tm1.1Hiso
Genetic Background: B6.129P2-Capn3tm1.1Hiso

 MP:0003324 liver adenoma "benign epithelial neoplasm of the liver" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Capn3tm1.1Hiso/Capn3tm1.1Hiso
Genetic Background: B6.129P2-Capn3tm1.1Hiso

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Capn3tm1.1Hiso/Capn3tm1.1Hiso
Genetic Background: B6.129P2-Capn3tm1.1Hiso

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Capn3tm1.1Hiso/Capn3tm1.1Hiso
Genetic Background: B6.129P2-Capn3tm1.1Hiso

 MP:0003893 increased hepatocyte proliferation "anomalous growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Capn3tm1.1Hiso/Capn3tm1.1Hiso
Genetic Background: B6.129P2-Capn3tm1.1Hiso

 MP:0003983 decreased cholesterol level "less than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Capn3tm1.1Hiso/Capn3tm1.1Hiso
Genetic Background: B6.129P2-Capn3tm1.1Hiso

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Capn3tm1.1Hiso/Capn3tm1.1Hiso
Genetic Background: B6.129P2-Capn3tm1.1Hiso

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Capn3tm1.1Hiso/Capn3tm1.1Hiso
Genetic Background: B6.129P2-Capn3tm1.1Hiso

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Capn3tm1.1Hiso/Capn3tm1.1Hiso
Genetic Background: B6.129P2-Capn3tm1.1Hiso

 MP:0008114 abnormal Kupffer cell morphology "any structural anomaly of the phagocytic macrophages residing on the luminal surface of the hepatic sinusoids" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Capn3tm1.1Hiso/Capn3tm1.1Hiso
Genetic Background: B6.129P2-Capn3tm1.1Hiso

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Capn3tm1.1Hiso/Capn3tm1.1Hiso
Genetic Background: B6.129P2-Capn3tm1.1Hiso

 MP:0010040 abnormal oval cell morphology "any structural anomaly of adult liver-specific stem cells; a blast-like cell capable of self renewal and multipotent differentiation, the oval cell is capable of differentiating into mature hepatocytes or cholangiocytes" [PMID:16237666]
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Allelic Composition: Capn3tm1.1Hiso/Capn3tm1.1Hiso
Genetic Background: B6.129P2-Capn3tm1.1Hiso

 MP:0010042 abnormal oval cell physiology "any functional anomaly of adult liver-specific stem cells; a blast-like cell capable of self renewal and multipotent differentiation, the oval cell is capable of differentiating into mature hepatocytes or cholangiocytes" [PMID:16237666]
Show

Allelic Composition: Capn3tm1.1Hiso/Capn3tm1.1Hiso
Genetic Background: B6.129P2-Capn3tm1.1Hiso

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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