ENSMUSG00000021371


Mus musculus

Features
Gene ID: ENSMUSG00000021371
  
Biological name :Mcur1
  
Synonyms : Mcur1 / Mitochondrial calcium uniporter regulator 1 / Q9CXD6
  
Possible biological names infered from orthology : Q96AQ8
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A4
Gene start: 43538393
Gene end: 43560191
  
Corresponding Affymetrix probe sets: 10408902 (MoGene1.0st)   1438024_at (Mouse Genome 430 2.0 Array)   1453732_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021800
NCBI entrez gene - 76137     See in Manteia.
MGI - MGI:1923387
RefSeq - NM_001081059
RefSeq Peptide - NP_001074528
swissprot - Q9CXD6
Ensembl - ENSMUSG00000021371
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:165532ENSDARG00000016964Danio rerio
 MCUR1ENSGALG00000012699Gallus gallus
 MCUR1ENSG00000050393Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8C3X2 / Ccdc90b / Coiled-coil domain-containing protein 90B, mitochondrial / Q9GZT6* / coiled-coil domain containing 90B*ENSMUSG0000003061329


Protein motifs (from Interpro)
Interpro ID Name
 IPR012439  Mitochondrial calcium uniporter regulator 1
 IPR024461  Coiled-coil domain-containing protein 90-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006851 mitochondrial calcium ion transmembrane transport IBA
 biological_processGO:0036444 calcium import into the mitochondrion IEA
 biological_processGO:0051561 positive regulation of mitochondrial calcium ion concentration IEA
 biological_processGO:0070509 calcium ion import IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031305 integral component of mitochondrial inner membrane IEA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Emdtm1.1Stw/Y
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Mcur1tm1c(KOMP)Wtsi/Mcur1tm1c(KOMP)Wtsi,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * FVB/N

Allelic Composition: Mcur1tm1c(KOMP)Wtsi/Mcur1tm1c(KOMP)Wtsi,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * FVB/N

 MP:0008965 increased basal metabolism "increase in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [MESH:E01.370.374.750.100]
Show

Allelic Composition: Mcur1tm1c(KOMP)Wtsi/Mcur1tm1c(KOMP)Wtsi,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * FVB/N

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Mcur1tm1c(KOMP)Wtsi/Mcur1tm1c(KOMP)Wtsi,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * FVB/N

 MP:0011134 decreased lung endothelial cell migration "reduced or slower movement of endothelial cells or their precursors to the appropriate location in the pulmonary vasculature" [MGI:csmith]
Show

Allelic Composition: Mcur1tm1c(KOMP)Wtsi/Mcur1tm1c(KOMP)Wtsi,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * FVB/N

 MP:0011140 decreased lung endothelial cell proliferation "reduced ability of an endothelial cell in the pulmonary vasculature to undergo expansion by cell division" [MGI:csmith]
Show

Allelic Composition: Mcur1tm1c(KOMP)Wtsi/Mcur1tm1c(KOMP)Wtsi,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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