ENSMUSG00000021376


Mus musculus

Features
Gene ID: ENSMUSG00000021376
  
Biological name :Tpmt
  
Synonyms : thiopurine S-methyltransferase / Tpmt
  
Possible biological names infered from orthology : P51580
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A5
Gene start: 47022482
Gene end: 47044737
  
Corresponding Affymetrix probe sets: 10409021 (MoGene1.0st)   1419121_at (Mouse Genome 430 2.0 Array)   1430889_a_at (Mouse Genome 430 2.0 Array)   1438087_at (Mouse Genome 430 2.0 Array)   1456273_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021806
Ensembl peptide - ENSMUSP00000152893
Ensembl peptide - ENSMUSP00000121827
Ensembl peptide - ENSMUSP00000120564
Ensembl peptide - ENSMUSP00000120081
Ensembl peptide - ENSMUSP00000115361
Ensembl peptide - ENSMUSP00000105745
NCBI entrez gene - 22017     See in Manteia.
MGI - MGI:98812
RefSeq - XM_011244399
RefSeq - NM_016785
RefSeq - XM_006516925
RefSeq - XM_006516926
RefSeq - XM_011244396
RefSeq - XM_011244397
RefSeq - XM_011244398
RefSeq Peptide - NP_058065
swissprot - D3Z217
swissprot - D3Z0R1
swissprot - D3YWK6
swissprot - A0A286YCA5
swissprot - A0A0R4J018
swissprot - D6RIK3
swissprot - D3Z380
Ensembl - ENSMUSG00000021376
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tpmt.1ENSDARG00000055974Danio rerio
 tpmt.1ENSDARG00000028012Danio rerio
 TPMTENSGALG00000012687Gallus gallus
 TPMTENSG00000137364Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008854  TPMT family
 IPR025835  Thiopurine S-methyltransferase
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0032259 methylation IEA
 molecular_functionGO:0008119 thiopurine S-methyltransferase activity IEA
 molecular_functionGO:0008757 S-adenosylmethionine-dependent methyltransferase activity IEA


Pathways (from Reactome)
Pathway description
Methylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Arsbtm1Cptr/Arsbtm1Cptr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Tpmttm1Rlng/Tpmt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NMRI

 MP:0002429 abnormal blood cell morphology/development "anomalous structure, differentiation, or number of any of the cells found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Arsbtm1Cptr/Arsbtm1Cptr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0003806 abnormal nucleotide metabolism "impaired regulation of nucleotide levels in either production or breakdown of these structural components of nucleic acids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Arsbtm1Cptr/Arsbtm1Cptr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Tpmttm1Rlng/Tpmt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NMRI

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Arsbtm1Cptr/Arsbtm1Cptr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Tpmttm1Rlng/Tpmt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NMRI

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arsbtm1Cptr/Arsbtm1Cptr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Tpmttm1Rlng/Tpmt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NMRI

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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