ENSMUSG00000021461


Mus musculus

Features
Gene ID: ENSMUSG00000021461
  
Biological name :Fancc
  
Synonyms : Fancc / Mus musculus Fanconi anemia, complementation group C (Fancc), transcript variant 4, mRNA. / P50652
  
Possible biological names infered from orthology : Fanconi anemia complementation group C / Q00597
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: B3
Gene start: 63285043
Gene end: 63497278
  
Corresponding Affymetrix probe sets: 10410016 (MoGene1.0st)   1442265_at (Mouse Genome 430 2.0 Array)   1447632_at (Mouse Genome 430 2.0 Array)   1450861_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123972
Ensembl peptide - ENSMUSP00000123817
Ensembl peptide - ENSMUSP00000124165
Ensembl peptide - ENSMUSP00000152119
Ensembl peptide - ENSMUSP00000125710
Ensembl peptide - ENSMUSP00000124759
Ensembl peptide - ENSMUSP00000124406
Ensembl peptide - ENSMUSP00000124325
Ensembl peptide - ENSMUSP00000072788
Ensembl peptide - ENSMUSP00000097043
Ensembl peptide - ENSMUSP00000123767
NCBI entrez gene - 14088     See in Manteia.
MGI - MGI:95480
RefSeq - XM_017315382
RefSeq - XM_011244474
RefSeq - XM_011244475
RefSeq - XM_011244476
RefSeq - XM_011244477
RefSeq - XM_011244478
RefSeq - XM_011244479
RefSeq - XM_011244480
RefSeq - XM_011244481
RefSeq - XM_011244482
RefSeq - XM_011244483
RefSeq - XM_011244484
RefSeq - XM_011244485
RefSeq - XM_011244486
RefSeq - XM_011244487
RefSeq - NM_001042673
RefSeq - NM_001282942
RefSeq - NM_001347514
RefSeq - NM_007985
RefSeq - XM_006517087
RefSeq - XM_006517089
RefSeq - XM_006517090
RefSeq Peptide - NP_001334443
RefSeq Peptide - NP_032011
RefSeq Peptide - NP_001036138
RefSeq Peptide - NP_001269871
swissprot - E0CYC3
swissprot - F7DEE2
swissprot - E0CXC4
swissprot - E9QAE8
swissprot - P50652
swissprot - Q8CBR3
swissprot - A0A1Y7VKS5
swissprot - E0CYY7
swissprot - E0CYQ7
swissprot - E0CYI2
Ensembl - ENSMUSG00000021461
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fanccENSDARG00000055232Danio rerio
 FANCCENSGALG00000012618Gallus gallus
 FANCCENSG00000158169Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000686  Fanconi anaemia group C protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002262 myeloid cell homeostasis IMP
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006289 nucleotide-excision repair IMP
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007276 gamete generation IMP
 biological_processGO:0007281 germ cell development IMP
 biological_processGO:0019430 removal of superoxide radicals IGI
 biological_processGO:0034599 cellular response to oxidative stress IGI
 biological_processGO:0048854 brain morphogenesis IGI
 biological_processGO:0097150 neuronal stem cell population maintenance IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0043240 Fanconi anaemia nuclear complex IEA


Pathways (from Reactome)
Pathway description
Fanconi Anemia Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2tm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2tm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000239 deficiency of myeloid colony forming progenitor cells "lack of precursors of the myeloid cell types" [J:60630, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fancctm1Mgo/Fancctm1Mgo
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2tm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
Show

Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2tm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001121 uterine hypoplasia "reduced size of the uterus due to decreased cell number" [J:45065]
Show

Allelic Composition: Fancctm1Mgo/Fancctm1Mgo
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001129 impaired ovarian folliculogenesis "a block in the formation of the spherical ovum in the ovary" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
Show

Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001545 abnormal hematopoietic system physiology "anomalous function of the fluid and/or its suspended elements that circulate(s) through the heart, arteries, capillaries, and veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Fancctm1Mgo/Fancctm1Mgo
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fancctm1Mgo/Fancctm1Mgo
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002160 abnormal reproductive system morphology "structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002209 germ cell depletion "reduced numbers of any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2tm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2tm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2tm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002619 abnormal lymphocyte morphology/development "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2tm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2tm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Fancctm1Mgo/Fancctm1Mgo
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002777 absent ovarian follicles "lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fancctm1Mgo/Fancctm1Mgo
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2tm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2tm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003155 abnormal telomere length "abnormal length of the terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability; normal length is a few hundred base pairs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sod1tm1Cep/Sod1tm1Cep
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004029 spontaneous chromosome breakage "chromosome breakage due to inherent instability of chromosomes" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fancctm1Mgo/Fancctm1Mgo
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0004030 induced chromosome breakage "chromosome breakage following treatment with a DNA-damaging agent " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fancctm1Mgo/Fancctm1Mgo
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0004045 abnormal cell cycle checkpoint function "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fancctm1Mgo/Fancctm1Mgo
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fancctm1Mgo/Fancctm1Mgo
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2tm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005097 polychromatophilia "condition characterized by the presence of red blood cells that have an affinity for acid, basic, and neutral stains" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:305]
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Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2tm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005158 ovary hypoplasia "underdeveloped ovaries, usually due to reduced cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:78931]
Show

Allelic Composition: Fancctm1Mgo/Fancctm1Mgo
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fancctm1Mgo/Fancctm1Mgo
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sod1tm1Cep/Sod1tm1Cep
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008249 abnormal common lymphocyte progenitor cell morphology "any structural anomaly of a progenitor cell committed to the lymphoid lineage" [CL:0000051, PMID:10407577]
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fancctm1Mab/Fancctm1Mab,Sod1tm1Cep/Sod1tm1Cep
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008404 increased cellular sensitivity to methylmethanesulfonate "greater incidence of cell death following exposure to methylmethanesulfonate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fancctm1Mab/Fancctm1Mab,Sod1tm1Cep/Sod1tm1Cep
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010080 abnormal hepatocyte physiology "any functional anomaly of the main structural specialized epithelial cells which normally organize into interconnected plates called lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fancctm1Mab/Fancctm1Mab,Sod1tm1Cep/Sod1tm1Cep
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010763 abnormal hematopoietic stem cell physiology "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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