ENSMUSG00000021501


Mus musculus

Features
Gene ID: ENSMUSG00000021501
  
Biological name :Caml
  
Synonyms : Calcium signal-modulating cyclophilin ligand / Caml / P49070
  
Possible biological names infered from orthology : calcium modulating ligand / CAMLG / P49069
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: B1
Gene start: 55623005
Gene end: 55632411
  
Corresponding Affymetrix probe sets: 10405504 (MoGene1.0st)   1417842_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021963
NCBI entrez gene - 12328     See in Manteia.
MGI - MGI:104728
RefSeq - NM_007596
RefSeq Peptide - NP_031622
swissprot - P49070
Ensembl - ENSMUSG00000021501
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 camlgENSDARG00000100409Danio rerio
 CAMLGENSGALG00000006411Gallus gallus
 CAMLGENSG00000164615Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR016719  Calcium signal-modulating cyclophilin ligand


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001881 receptor recycling IMP
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0050839 cell adhesion molecule binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Gdf7tm2Tmj/Gdf7+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129S1/Sv * FVB/N

Allelic Composition: Camltm1Rjb/Camltm2Rjb,Tg(Lck-cre)1Cwi/0,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0004918 abnormal negative T cell selection "any anomaly in the process of elimination of immature T cells which react strongly with self-antigens" [GO:0043383]
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Allelic Composition: Camltm1Rjb/Camltm2Rjb,Tg(Lck-cre)1Cwi/0,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0004919 abnormal positive T cell selection "any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death" [GO:0043368]
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Allelic Composition: Camltm1Rjb/Camltm2Rjb,Tg(Lck-cre)1Cwi/0,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gdf7tm2Tmj/Gdf7+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gdf7tm2Tmj/Gdf7+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Traf6tm1Ywc/Traf6tm1Ywc
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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