ENSMUSG00000021508


Mus musculus

Features
Gene ID: ENSMUSG00000021508
  
Biological name :Cxcl14
  
Synonyms : Cxcl14 / C-X-C motif chemokine 14 / Q9WUQ5
  
Possible biological names infered from orthology : C-X-C motif chemokine ligand 14 / O95715
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: B1
Gene start: 56288643
Gene end: 56296551
  
Corresponding Affymetrix probe sets: 10409579 (MoGene1.0st)   1418456_a_at (Mouse Genome 430 2.0 Array)   1418457_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021970
Ensembl peptide - ENSMUSP00000153440
NCBI entrez gene - 57266     See in Manteia.
MGI - MGI:1888514
RefSeq - XM_006517308
RefSeq - NM_019568
RefSeq Peptide - NP_062514
swissprot - Q6AXC2
swissprot - Q9WUQ5
Ensembl - ENSMUSG00000021508
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cxcl14ENSDARG00000056627Danio rerio
 CXCL14ENSGALG00000006346Gallus gallus
 CXCL14ENSG00000145824Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001811  Chemokine interleukin-8-like domain
 IPR036048  Chemokine interleukin-8-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0045662 negative regulation of myoblast differentiation IMP
 biological_processGO:0048839 inner ear development IDA
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:2000503 positive regulation of natural killer cell chemotaxis IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0008009 chemokine activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm2.1(Mirn150)Rsky/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * SJL/J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cxcl14tm1Tha/Cxcl14tm1Tha
Genetic Background: involves: C57BL/6 * CBA

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm2.1(Mirn150)Rsky/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * SJL/J

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cxcl14tm1Tha/Cxcl14tm1Tha
Genetic Background: involves: C57BL/6 * CBA

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Cxcl14tm1Tha/Cxcl14tm1Tha
Genetic Background: involves: C57BL/6 * CBA

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cxcl14tm1Tha/Cxcl14tm1Tha
Genetic Background: involves: C57BL/6 * CBA

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Cxcl14tm1Tha/Cxcl14tm1Tha
Genetic Background: involves: C57BL/6 * CBA

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Cxcl14tm1Tha/Cxcl14tm1Tha
Genetic Background: involves: C57BL/6 * CBA

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cxcl14tm1Tha/Cxcl14tm1Tha
Genetic Background: involves: C57BL/6 * CBA

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cxcl14tm1Tha/Cxcl14tm1Tha
Genetic Background: involves: C57BL/6 * CBA

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cxcl14tm1Tha/Cxcl14tm1Tha
Genetic Background: involves: C57BL/6 * CBA

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cxcl14tm1Tha/Cxcl14tm1Tha
Genetic Background: involves: C57BL/6 * CBA

 MP:0006094 adipocyte hypertrophy "increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802]
Show

Allelic Composition: Cxcl14tm1Tha/Cxcl14tm1Tha
Genetic Background: involves: C57BL/6 * CBA

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cxcl14tm1Tha/Cxcl14tm1Tha
Genetic Background: involves: C57BL/6 * CBA

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Cxcl14tm1Tha/Cxcl14tm1Tha
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Cxcl14tm1.1Rih/Cxcl14tm1.1Rih
Genetic Background: involves: C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Cxcl14tm1Tha/Cxcl14tm1Tha
Genetic Background: involves: C57BL/6 * CBA

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Cxcl14tm1Tha/Cxcl14tm1Tha
Genetic Background: involves: C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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