ENSMUSG00000021585


Mus musculus

Features
Gene ID: ENSMUSG00000021585
  
Biological name :Cast
  
Synonyms : Calpastatin / Cast / P51125
  
Possible biological names infered from orthology : P20810
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: C1
Gene start: 74692368
Gene end: 74808810
  
Corresponding Affymetrix probe sets: 10410656 (MoGene1.0st)   1426098_a_at (Mouse Genome 430 2.0 Array)   1435972_at (Mouse Genome 430 2.0 Array)   1451413_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152657
Ensembl peptide - ENSMUSP00000152504
Ensembl peptide - ENSMUSP00000152550
Ensembl peptide - ENSMUSP00000065275
Ensembl peptide - ENSMUSP00000152118
Ensembl peptide - ENSMUSP00000152174
Ensembl peptide - ENSMUSP00000152306
NCBI entrez gene - 12380     See in Manteia.
MGI - MGI:1098236
RefSeq - XM_017315374
RefSeq - NM_001301153
RefSeq - NM_001301155
RefSeq - NM_001301156
RefSeq - NM_001301157
RefSeq - NM_001301158
RefSeq - NM_001301160
RefSeq - NM_001301181
RefSeq - NM_009817
RefSeq - XM_006517056
RefSeq - XM_006517059
RefSeq - XM_011244466
RefSeq - XM_011244467
RefSeq - XM_011244469
RefSeq Peptide - NP_001288089
RefSeq Peptide - NP_001288110
RefSeq Peptide - NP_033947
RefSeq Peptide - NP_001288082
RefSeq Peptide - NP_001288084
RefSeq Peptide - NP_001288085
RefSeq Peptide - NP_001288086
RefSeq Peptide - NP_001288087
swissprot - Q921U7
swissprot - A0A1Y7VJN8
swissprot - P51125
swissprot - Q3TTN2
swissprot - Q8C281
swissprot - Q8CE04
swissprot - Q8CE80
Ensembl - ENSMUSG00000021585
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 castENSDARG00000058693Danio rerio
 CASTENSGALG00000014682Gallus gallus
 CASTENSG00000153113Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001259  Proteinase inhibitor I27, calpastatin
 IPR026998  Calpastatin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010466 negative regulation of peptidase activity IGI
 biological_processGO:0030163 protein catabolic process ISA
 biological_processGO:0097340 inhibition of cysteine-type endopeptidase activity ISO
 biological_processGO:2000675 negative regulation of type B pancreatic cell apoptotic process ISO
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016020 membrane ISO
 molecular_functionGO:0004869 cysteine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity ISO
 molecular_functionGO:0030414 peptidase inhibitor activity IEA
 molecular_functionGO:0045296 cadherin binding ISO


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Cacna1stm1.1(KOMP)Vlcg/Cacna1stm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cacna1stm1.1(KOMP)Vlcg/J

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Cacna1stm1.1(KOMP)Vlcg/Cacna1stm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cacna1stm1.1(KOMP)Vlcg/J

 MP:0000579 abnormal nail morphology "structural or developmental anomaly of any of the thin, horny, translucent plates covering the dorsal surface of the distal end of each terminal phalanx of the digits" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cacna1stm1.1(KOMP)Vlcg/Cacna1stm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cacna1stm1.1(KOMP)Vlcg/J

 MP:0000604 amyloidosis "an accumulation of extracellular amyloid in tissues of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apptm2.1Tcs/Apptm2.1Tcs,Casttm1Tcs/Casttm1Tcs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Cacna1stm1.1(KOMP)Vlcg/Cacna1stm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cacna1stm1.1(KOMP)Vlcg/J

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Cacna1stm1.1(KOMP)Vlcg/Cacna1stm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cacna1stm1.1(KOMP)Vlcg/J

 MP:0001566 hyperphosphatemia "abnormally high concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cacna1stm1.1(KOMP)Vlcg/Cacna1stm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cacna1stm1.1(KOMP)Vlcg/J

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Capn2tm1Tcs/Capn2tm1Tcs,Casttm1Tcs/Casttm1Tcs
Genetic Background: B6.129-Capn2tm1Tcs Casttm1Tcs

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apptm2.1Tcs/Apptm2.1Tcs,Casttm1Tcs/Casttm1Tcs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1stm1.1(KOMP)Vlcg/Cacna1stm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cacna1stm1.1(KOMP)Vlcg/J

 MP:0003329 amyloid beta deposits 
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Allelic Composition: Apptm2.1Tcs/Apptm2.1Tcs,Casttm1Tcs/Casttm1Tcs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apptm2.1Tcs/Apptm2.1Tcs,Casttm1Tcs/Casttm1Tcs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005507 tail dragging "pulling the tail along with difficulty or effort; may be due to paralysis or weakness" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cacna1stm1.1(KOMP)Vlcg/Cacna1stm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cacna1stm1.1(KOMP)Vlcg/J

 MP:0008235 increased susceptibility to neuronal excitotoxicity "greater than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fxntm1Mkn/Fxntm1Pand
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008918 microgliosis "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apptm2.1Tcs/Apptm2.1Tcs,Casttm1Tcs/Casttm1Tcs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1stm1.1(KOMP)Vlcg/Cacna1stm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cacna1stm1.1(KOMP)Vlcg/J

 MP:0010769 abnormal survival "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Capn2tm1Tcs/Capn2tm1Tcs
Genetic Background: B6.129S-Capn2tm1Tcs

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Capn1tm1Ahc/Capn1tm1Ahc,Capn2tm1Tcs/Capn2tm1Tcs,Casttm1Tcs/Casttm1Tcs
Genetic Background: B6.129-Capn2tm1Tcs Casttm1Tcs Capn1tm1Ahc

 MP:0012000 abnormal limb position "anomaly in the location of the limbs on the body relative to other body parts or axes" [MGI:csmith]
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Allelic Composition: Cacna1stm1.1(KOMP)Vlcg/Cacna1stm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cacna1stm1.1(KOMP)Vlcg/J

 MP:0013278 decreased fasted circulating glucose level "reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Cacna1stm1.1(KOMP)Vlcg/Cacna1stm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cacna1stm1.1(KOMP)Vlcg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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