ENSMUSG00000021589


Mus musculus

Features
Gene ID: ENSMUSG00000021589
  
Biological name :Rhobtb3
  
Synonyms : Q9CTN4 / Rhobtb3 / Rho-related BTB domain-containing protein 3
  
Possible biological names infered from orthology : O94955 / Rho related BTB domain containing 3
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: C1
Gene start: 75869537
Gene end: 75943925
  
Corresponding Affymetrix probe sets: 10410695 (MoGene1.0st)   1429661_at (Mouse Genome 430 2.0 Array)   1433647_s_at (Mouse Genome 430 2.0 Array)   1447869_x_at (Mouse Genome 430 2.0 Array)   1453227_at (Mouse Genome 430 2.0 Array)   1457009_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152801
Ensembl peptide - ENSMUSP00000022078
Ensembl peptide - ENSMUSP00000105235
Ensembl peptide - ENSMUSP00000152589
NCBI entrez gene - 73296     See in Manteia.
MGI - MGI:1920546
RefSeq - XM_011244574
RefSeq - NM_028493
RefSeq - XM_006517410
RefSeq - XM_006517411
RefSeq - XM_006517412
RefSeq - XM_011244573
RefSeq Peptide - NP_082769
swissprot - A0A1Y7VMM2
swissprot - A0A1Y7VJQ5
swissprot - Q8BV11
swissprot - Q9CTN4
Ensembl - ENSMUSG00000021589
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RHOBTB3ENSDARG00000090036Danio rerio
 RHOBTB3ENSGALG00000014675Gallus gallus
 O94955ENSG00000164292Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR001806  Small GTPase superfamily
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR031260  Rho-related BTB domain-containing protein 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008584 male gonad development IMP
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0042147 retrograde transport, endosome to Golgi IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0017137 Rab GTPase binding IEA


Pathways (from Reactome)
Pathway description
Retrograde transport at the Trans-Golgi-Network


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prkab1tm1a(KOMP)Wtsi/Prkab1tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Prkab1tm1a(KOMP)Wtsi/Wtsi

 MP:0000443 abnormal snout morphology "anomalous structure or development of the anterior facial part of the muzzle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkab1tm1a(KOMP)Wtsi/Prkab1tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Prkab1tm1a(KOMP)Wtsi/Wtsi

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Prkab1tm1a(KOMP)Wtsi/Prkab1tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Prkab1tm1a(KOMP)Wtsi/Wtsi

Allelic Composition: Rhobtb3tm1a(KOMP)Wtsi/Rhobtb3tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Disc1m1H/Disc1m1H
Genetic Background: B6N.C(C3H)-Disc1m1H

Allelic Composition: Rhobtb3tm1a(KOMP)Wtsi/Rhobtb3tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Rhobtb3tm1a(KOMP)Wtsi/Wtsi

Allelic Composition: Rhobtb3tm1a(KOMP)Wtsi/Rhobtb3tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Disc1m1H/Disc1m1H
Genetic Background: B6N.C(C3H)-Disc1m1H

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Rhobtb3tm1a(KOMP)Wtsi/Rhobtb3tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prkab1tm1a(KOMP)Wtsi/Prkab1tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Prkab1tm1a(KOMP)Wtsi/Wtsi

Allelic Composition: Rhobtb3tm1a(KOMP)Wtsi/Rhobtb3tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rhobtb3tm1a(KOMP)Wtsi/Rhobtb3tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Rhobtb3tm1a(KOMP)Wtsi/Wtsi

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Disc1m1H/Disc1m1H
Genetic Background: B6N.C(C3H)-Disc1m1H

 MP:0002932 abnormal joint "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rhobtb3tm1a(KOMP)Wtsi/Rhobtb3tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Rhobtb3tm1a(KOMP)Wtsi/Wtsi

Allelic Composition: Rhobtb3tm1a(KOMP)Wtsi/Rhobtb3tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Disc1m1H/Disc1m1H
Genetic Background: B6N.C(C3H)-Disc1m1H

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Rhobtb3tm1a(KOMP)Wtsi/Rhobtb3tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Rhobtb3tm1a(KOMP)Wtsi/Wtsi

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Disc1m1H/Disc1m1H
Genetic Background: B6N.C(C3H)-Disc1m1H

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Disc1m1H/Disc1m1H
Genetic Background: B6N.C(C3H)-Disc1m1H

 MP:0005353 abnormal patella morphology "anomalous structure of the large sesamoid bone that covers the anterior surface of the knee" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47316]
Show

Allelic Composition: Rhobtb3tm1a(KOMP)Wtsi/Rhobtb3tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhobtb3tm1a(KOMP)Wtsi/Rhobtb3tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhobtb3tm1a(KOMP)Wtsi/Rhobtb3tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Rhobtb3tm1a(KOMP)Wtsi/Wtsi

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Rhobtb3tm1a(KOMP)Wtsi/Rhobtb3tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rhobtb3tm1a(KOMP)Wtsi/Rhobtb3tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Rhobtb3tm1a(KOMP)Wtsi/Wtsi

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Disc1m1H/Disc1m1H
Genetic Background: B6N.C(C3H)-Disc1m1H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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