ENSMUSG00000021606


Mus musculus

Features
Gene ID: ENSMUSG00000021606
  
Biological name :Ndufs6
  
Synonyms : NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial / Ndufs6 / P52503
  
Possible biological names infered from orthology : NADH:ubiquinone oxidoreductase subunit S6 / O75380
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: C1
Gene start: 73319838
Gene end: 73328542
  
Corresponding Affymetrix probe sets: 10410508 (MoGene1.0st)   1433603_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022097
Ensembl peptide - ENSMUSP00000152495
Ensembl peptide - ENSMUSP00000152073
Ensembl peptide - ENSMUSP00000119457
NCBI entrez gene - 407785     See in Manteia.
MGI - MGI:107932
RefSeq - NM_010888
RefSeq Peptide - NP_035018
swissprot - A0A1Y7VM38
swissprot - A0A1Y7VKP8
swissprot - D6RJ54
swissprot - P52503
Ensembl - ENSMUSG00000021606
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ndufs6ENSDARG00000056583Danio rerio
 NDUFS6ENSGALG00000013191Gallus gallus
 NDUFS6ENSG00000145494Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR016668  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
 IPR019401  Zinc finger, CHCC-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006120 mitochondrial electron transport, NADH to ubiquinone IBA
 biological_processGO:0006631 fatty acid metabolic process IMP
 biological_processGO:0006936 muscle contraction IMP
 biological_processGO:0010259 multicellular organism aging IMP
 biological_processGO:0022904 respiratory electron transport chain IMP
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0061458 reproductive system development IMP
 biological_processGO:0070584 mitochondrion morphogenesis IMP
 biological_processGO:0072358 cardiovascular system development IMP
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005747 mitochondrial respiratory chain complex I IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0070469 respiratory chain IEA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
Respiratory electron transport
Complex I biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0003819 increased left ventricle diastolic pressure "increase in the pressure in the left ventricle between heart beats when the heart is relaxed" [RGD:Rat Genome Database submission]
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Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0003822 decreased left ventricle systolic pressure "decrease in the pressure in the left ventricle as the heart contracts and pumps blood into the arteries" [RGD:Rat Genome Database submission]
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Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0003913 increased right ventricle weight "greater than average weight of the right ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0003915 increased left ventricle weight "greater than average weight of the left ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0004084 abnormal cardiac muscle relaxation "altered ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0005281 increased fatty acid level "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0008772 enlarged heart ventricle "increased average size of the heart ventricles compared to the average for a particular population" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0010563 increased heart right ventricle size "greater than average size of the right ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0010579 increased heart left ventricle size "greater than average size of the left ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0010955 abnormal respiratory electron transport chain "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]
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Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0011631 decreased mitochondria size "reduced size of the cellular organelles responsible for energy production" [MGI:csmith]
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Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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