ENSMUSG00000021647


Mus musculus

Features
Gene ID: ENSMUSG00000021647
  
Biological name :Cartpt
  
Synonyms : Cartpt / Cocaine- and amphetamine-regulated transcript protein CART(1-52) CART(55-102) CART(62-102) / P56388
  
Possible biological names infered from orthology : CART prepropeptide / Q16568
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: D1
Gene start: 99898489
Gene end: 99901091
  
Corresponding Affymetrix probe sets: 10411527 (MoGene1.0st)   1422825_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022150
Ensembl peptide - ENSMUSP00000152981
NCBI entrez gene - 27220     See in Manteia.
MGI - MGI:1351330
RefSeq - NM_013732
RefSeq - NM_001081493
RefSeq Peptide - NP_001074962
RefSeq Peptide - NP_038760
swissprot - P56388
swissprot - Q3UYI4
Ensembl - ENSMUSG00000021647
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BX470229.2ENSDARG00000104363Danio rerio
 cart1ENSDARG00000070930Danio rerio
 CARTPTENSGALG00000038241Gallus gallus
 CARTPTENSG00000164326Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009106  CART satiety factor
 IPR036722  CART, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity IDA
 biological_processGO:0001678 cellular glucose homeostasis ISS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007218 neuropeptide signaling pathway TAS
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0007268 chemical synaptic transmission IEA
 biological_processGO:0008343 adult feeding behavior IDA
 biological_processGO:0009267 cellular response to starvation ISS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0032099 negative regulation of appetite IMP
 biological_processGO:0032812 positive regulation of epinephrine secretion ISO
 biological_processGO:0032922 circadian regulation of gene expression ISS
 biological_processGO:0045671 negative regulation of osteoclast differentiation TAS
 biological_processGO:0045777 positive regulation of blood pressure ISS
 biological_processGO:0045779 negative regulation of bone resorption IGI
 biological_processGO:0046850 regulation of bone remodeling IMP
 biological_processGO:0050796 regulation of insulin secretion IEA
 biological_processGO:0051971 positive regulation of transmission of nerve impulse ISO
 biological_processGO:0070093 negative regulation of glucagon secretion IEA
 biological_processGO:0070253 somatostatin secretion IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0030141 secretory granule ISO
 molecular_functionGO:0005184 neuropeptide hormone activity TAS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Ntrk2tm1Lfp/Ntrk2tm1Lfp
Genetic Background: involves: 129

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ntrk2tm1Lfp/Ntrk2tm1Lfp
Genetic Background: involves: 129

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ntrk2tm1Lfp/Ntrk2tm1Lfp
Genetic Background: involves: 129

 MP:0004016 decreased bone mass "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Adrb2tm1Bkk/Adrb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adrb2tm1Bkk/Adrb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adrb2tm1Bkk/Adrb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ntrk2tm1Lfp/Ntrk2tm1Lfp
Genetic Background: involves: 129

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Raxtm1.2Lwd/Raxtm1.2Lwd
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cartpttm1Hmh/Cartpt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Raxtm1.2Lwd/Raxtm1.2Lwd
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cartpttm1Hmh/Cartpt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Raxtm1.2Lwd/Raxtm1.2Lwd
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cartpttm1Hmh/Cartpt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr