ENSMUSG00000021785


Mus musculus

Features
Gene ID: ENSMUSG00000021785
  
Biological name :Ngly1
  
Synonyms : Ngly1 / Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase / Q9JI78
  
Possible biological names infered from orthology : N-glycanase 1 / Q96IV0
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: A2
Gene start: 16249280
Gene end: 16311926
  
Corresponding Affymetrix probe sets: 10412830 (MoGene1.0st)   1417827_at (Mouse Genome 430 2.0 Array)   1440463_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022310
Ensembl peptide - ENSMUSP00000153445
Ensembl peptide - ENSMUSP00000153025
Ensembl peptide - ENSMUSP00000152998
NCBI entrez gene - 59007     See in Manteia.
MGI - MGI:1913276
RefSeq - NM_021504
RefSeq Peptide - NP_067479
swissprot - A0A286YCZ7
swissprot - A0A286YCI0
swissprot - A0A286YDI5
swissprot - Q9JI78
Ensembl - ENSMUSG00000021785
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ngly1ENSDARG00000003205Danio rerio
 NGLY1ENSGALG00000011304Gallus gallus
 NGLY1ENSG00000151092Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002931  Transglutaminase-like
 IPR006588  Peptide N glycanase, PAW domain
 IPR008979  Galactose-binding-like domain superfamily
 IPR018997  PUB domain
 IPR036339  PUB-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006515 protein quality control for misfolded or incompletely synthesized proteins IBA
 biological_processGO:0006516 glycoprotein catabolic process IEA
 biological_processGO:0006517 protein deglycosylation IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0000224 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
N-glycan trimming in the ER and Calnexin/Calreticulin cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Esyt2Gt(AN0678)Wtsi/Esyt2Gt(AN0678)Wtsi,Esyt3tm1d(EUCOMM)Wtsi/Esyt3tm1d(EUCOMM)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Disc1m1H/Disc1m1H
Genetic Background: B6N.C(C3H)-Disc1m1H

Allelic Composition: Ngly1em10Lutzy/Ngly1em10Lutzy
Genetic Background: C57BL/6J-Ngly1em10Lutzy/J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Disc1m1H/Disc1m1H
Genetic Background: B6N.C(C3H)-Disc1m1H

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Disc1m1H/Disc1m1H
Genetic Background: B6N.C(C3H)-Disc1m1H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr