ENSMUSG00000021910


Mus musculus

Features
Gene ID: ENSMUSG00000021910
  
Biological name :Nisch
  
Synonyms : Mus musculus nischarin (Nisch), transcript variant 2, mRNA. / Nisch / Q80TM9
  
Possible biological names infered from orthology : nischarin / Q9Y2I1
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: B
Gene start: 31170930
Gene end: 31216946
  
Corresponding Affymetrix probe sets: 10418578 (MoGene1.0st)   1430151_at (Mouse Genome 430 2.0 Array)   1433757_a_at (Mouse Genome 430 2.0 Array)   1433758_at (Mouse Genome 430 2.0 Array)   1451338_at (Mouse Genome 430 2.0 Array)   1452156_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000132842
Ensembl peptide - ENSMUSP00000022469
Ensembl peptide - ENSMUSP00000126001
Ensembl peptide - ENSMUSP00000126982
Ensembl peptide - ENSMUSP00000127132
Ensembl peptide - ENSMUSP00000129547
Ensembl peptide - ENSMUSP00000130210
Ensembl peptide - ENSMUSP00000131465
Ensembl peptide - ENSMUSP00000131623
Ensembl peptide - ENSMUSP00000131861
Ensembl peptide - ENSMUSP00000132413
NCBI entrez gene - 64652     See in Manteia.
MGI - MGI:1928323
RefSeq - XM_006519354
RefSeq - NM_001347583
RefSeq - NM_022656
RefSeq Peptide - NP_001334512
RefSeq Peptide - NP_073147
swissprot - Q80TM9
swissprot - F6YR29
swissprot - F6ZL69
swissprot - F7AVB2
swissprot - F7AFP3
swissprot - F6ZL22
Ensembl - ENSMUSG00000021910
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nischENSDARG00000043077Danio rerio
 NISCHENSGALG00000043825Gallus gallus
 NISCHENSG00000010322Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q3TAA7 / Stk11ip / Serine/threonine-protein kinase 11-interacting protein / serine/threonine kinase 11 interacting protein*ENSMUSG0000002621314


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR001683  Phox homologous domain
 IPR025875  Leucine rich repeat 4
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036871  PX domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0008217 regulation of blood pressure IEA
 biological_processGO:0016601 Rac protein signal transduction IDA
 biological_processGO:0030036 actin cytoskeleton organization IDA
 biological_processGO:0030336 negative regulation of cell migration IDA
 biological_processGO:0032228 regulation of synaptic transmission, GABAergic IEA
 biological_processGO:0048243 norepinephrine secretion IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0055037 recycling endosome IEA
 molecular_functionGO:0005178 integrin binding IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0035091 phosphatidylinositol binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ncoa3tm1b(EUCOMM)Wtsi/Ncoa3+
Genetic Background: C57BL/6N-Ncoa3tm1b(EUCOMM)Wtsi/H

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
Show

Allelic Composition: Cmtm7tm2a(EUCOMM)Hmgu/Cmtm7+,Rag1tm1Fwa/Rag1tm1Fwa
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0000455 abnormal maxilla morphology "malformation of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ncoa3tm1b(EUCOMM)Wtsi/Ncoa3+
Genetic Background: C57BL/6N-Ncoa3tm1b(EUCOMM)Wtsi/H

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Cmtm7tm2a(EUCOMM)Hmgu/Cmtm7+,Rag1tm1Fwa/Rag1tm1Fwa
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Cmtm7tm2a(EUCOMM)Hmgu/Cmtm7+,Rag1tm1Fwa/Rag1tm1Fwa
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cmtm7tm2a(EUCOMM)Hmgu/Cmtm7+,Rag1tm1Fwa/Rag1tm1Fwa
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001850 otitis media "middle ear inflammation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]
Show

Allelic Composition: Cmtm7tm2a(EUCOMM)Hmgu/Cmtm7+,Rag1tm1Fwa/Rag1tm1Fwa
Genetic Background: involves: C57BL/6 * C57BL/6N

Allelic Composition: Itga5tm1Hyn/Itga5+,Nischedsn/Nischedsn
Genetic Background: C3H.Cg-Nischedsn Itga5tm1Hyn

Allelic Composition: Itga5tm1Hyn/Itga5+,Nischedsn/Nisch+
Genetic Background: C3H.Cg-Nischedsn Itga5tm1Hyn

Allelic Composition: Nischedsn/NischV33A
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

Allelic Composition: NischV33A/NischV33A
Genetic Background: involves: BALB/c * C57BL/6J

 MP:0001958 emphysema "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629]
Show

Allelic Composition: Cmtm7tm2a(EUCOMM)Hmgu/Cmtm7+,Rag1tm1Fwa/Rag1tm1Fwa
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0005105 abnormal middle ear ossicle morphology "anomalous structure or development of the three small bones of the middle ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cmtm7tm2a(EUCOMM)Hmgu/Cmtm7+,Rag1tm1Fwa/Rag1tm1Fwa
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0006018 abnormal tympanic membrane morphology "any structural alterations in the thin, tense membrane forming the greater part of the lateral wall of the tympanic cavity and separating it from the external acoustic meatus; the tympanic membrane consitutes the boundary between the external and middle ear." [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, J:46639:]
Show

Allelic Composition: Cmtm7tm2a(EUCOMM)Hmgu/Cmtm7+,Rag1tm1Fwa/Rag1tm1Fwa
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cmtm7tm2a(EUCOMM)Hmgu/Cmtm7+,Rag1tm1Fwa/Rag1tm1Fwa
Genetic Background: involves: C57BL/6 * C57BL/6N

Allelic Composition: Itga5tm1Hyn/Itga5+,Nischedsn/Nischedsn
Genetic Background: C3H.Cg-Nischedsn Itga5tm1Hyn

Allelic Composition: Itga5tm1Hyn/Itga5+,Nischedsn/Nisch+
Genetic Background: C3H.Cg-Nischedsn Itga5tm1Hyn

Allelic Composition: NischV33A/NischV33A
Genetic Background: involves: BALB/c * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cmtm7tm2a(EUCOMM)Hmgu/Cmtm7+,Rag1tm1Fwa/Rag1tm1Fwa
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0011142 abnormal lung-associated mesenchyme development "abnormality in the formation of the lung tissue comprised of multiple cell types (including connective tissue, endothelial cells, lymphatics, smooth muscle cells surrounding airways and blood vessels, myofibroblasts involved in septum formation, and cartilage-forming cells in the trachea), with most cells thought to be derived from the splanchnic mesenchyme, and other cells (endothelial, smooth muscle) believed to invade the lung as it expands; lung mesenchyme is a critical determinant of the shape and size of the developing lung, the extent and patterning of epithelial branching, and the formation of the pulmonary vasculature and interstitial mesenchymal components of the adult lung" [MGI:anna, PMID:18533146, PMID:20048339]
Show

Allelic Composition: Cmtm7tm2a(EUCOMM)Hmgu/Cmtm7+,Rag1tm1Fwa/Rag1tm1Fwa
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Ncoa3tm1b(EUCOMM)Wtsi/Ncoa3+
Genetic Background: C57BL/6N-Ncoa3tm1b(EUCOMM)Wtsi/H

Allelic Composition: Nischedsn/Nischedsn
Genetic Background: C3H.B6-Nischedsn

Allelic Composition: Itga5tm1Hyn/Itga5+,Nischedsn/Nischedsn
Genetic Background: C3H.Cg-Nischedsn Itga5tm1Hyn

Allelic Composition: Nischedsn/NischV33A
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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