ENSMUSG00000021932


Mus musculus

Features
Gene ID: ENSMUSG00000021932
  
Biological name :Rnaseh2b
  
Synonyms : Q80ZV0 / Ribonuclease H2 subunit B / Rnaseh2b
  
Possible biological names infered from orthology : Q5TBB1
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: D1
Gene start: 62292589
Gene end: 62372992
  
Corresponding Affymetrix probe sets: 10415791 (MoGene1.0st)   1453001_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000129165
Ensembl peptide - ENSMUSP00000132267
Ensembl peptide - ENSMUSP00000022499
NCBI entrez gene - 67153     See in Manteia.
MGI - MGI:1914403
RefSeq - NM_026001
RefSeq Peptide - NP_080277
swissprot - Q80ZV0
swissprot - E9PYC5
swissprot - F6WF94
Ensembl - ENSMUSG00000021932
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rnaseh2bENSDARG00000005128Danio rerio
 RNASEH2BENSGALG00000017015Gallus gallus
 Q5TBB1ENSG00000136104Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR019024  Ribonuclease H2, subunit B


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0006401 RNA catabolic process IEA
 biological_processGO:0009259 ribonucleotide metabolic process IMP
 biological_processGO:0010389 regulation of G2/M transition of mitotic cell cycle IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0048146 positive regulation of fibroblast proliferation IMP
 biological_processGO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA
 biological_processGO:2000001 regulation of DNA damage checkpoint IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0032299 ribonuclease H2 complex IEA
 molecular_functionGO:0004523 RNA-DNA hybrid ribonuclease activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lepob/Lepob,Tg(Myh6-Med13)1Eno/0
Genetic Background: involves: C57BL/6

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lepob/Lepob,Tg(Myh6-Med13)1Eno/0
Genetic Background: involves: C57BL/6

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
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Allelic Composition: Lepob/Lepob,Tg(Myh6-Med13)1Eno/0
Genetic Background: involves: C57BL/6

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lepob/Lepob,Tg(Myh6-Med13)1Eno/0
Genetic Background: involves: C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Lepob/Lepob,Tg(Myh6-Med13)1Eno/0
Genetic Background: involves: C57BL/6

Allelic Composition: Rnaseh2btm1a(EUCOMM)Wtsi/Rnaseh2btm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

Allelic Composition: Rnaseh2btm1a(EUCOMM)Wtsi/Rnaseh2btm1a(EUCOMM)Wtsi,Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
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Allelic Composition: Lepob/Lepob,Tg(Myh6-Med13)1Eno/0
Genetic Background: involves: C57BL/6

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Lepob/Lepob,Tg(Myh6-Med13)1Eno/0
Genetic Background: involves: C57BL/6

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Lepob/Lepob,Tg(Myh6-Med13)1Eno/0
Genetic Background: involves: C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rnaseh2btm1a(EUCOMM)Wtsi/Rnaseh2btm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rnaseh2btm1a(EUCOMM)Wtsi/Rnaseh2btm1a(EUCOMM)Wtsi,Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
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Allelic Composition: Rnaseh2btm1a(EUCOMM)Wtsi/Rnaseh2btm1a(EUCOMM)Wtsi,Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lepob/Lepob,Tg(Myh6-Med13)1Eno/0
Genetic Background: involves: C57BL/6

Allelic Composition: Rnaseh2btm1a(EUCOMM)Wtsi/Rnaseh2btm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

Allelic Composition: Rnaseh2btm1a(EUCOMM)Wtsi/Rnaseh2btm1a(EUCOMM)Wtsi,Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0004073 caudal body truncation "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lepob/Lepob,Tg(Myh6-Med13)1Eno/0
Genetic Background: involves: C57BL/6

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rnaseh2btm1c(EUCOMM)Wtsi/Rnaseh2btm1c(EUCOMM)Wtsi,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rnaseh2btm1c(EUCOMM)Wtsi/Rnaseh2btm1c(EUCOMM)Wtsi,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL

 MP:0008402 increased cellular sensitivity to alkylating agents "greater incidence of cell death following exposure to agents that cause DNA damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rnaseh2btm1a(EUCOMM)Wtsi/Rnaseh2btm1a(EUCOMM)Wtsi,Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
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Allelic Composition: Rnaseh2btm1a(EUCOMM)Wtsi/Rnaseh2btm1a(EUCOMM)Wtsi,Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Rnaseh2btm1a(EUCOMM)Wtsi/Rnaseh2btm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0009768 impaired somite development "atypical process of somite formation with the result of fewer or none of these cell masses being formed" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lepob/Lepob,Tg(Myh6-Med13)1Eno/0
Genetic Background: involves: C57BL/6

 MP:0010770 preweaning lethality "death anytime between fertilization and weaning (Mus: approximately 3-4 weeks of age)" [MGI:Sanger_Karp "Submission from Natasha Karp"]
Show

Allelic Composition: Lepob/Lepob,Tg(Myh6-Med13)1Eno/0
Genetic Background: involves: C57BL/6

Allelic Composition: Rnaseh2btm1a(EUCOMM)Wtsi/Rnaseh2btm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Rnaseh2btm1a(EUCOMM)Wtsi/Rnaseh2btm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

Allelic Composition: Ifnar1tm1Agt/Ifnar1tm1Agt,Rnaseh2btm1a(EUCOMM)Wtsi/Rnaseh2btm1a(EUCOMM)Wtsi
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Rnaseh2btm1c(EUCOMM)Wtsi/Rnaseh2btm1c(EUCOMM)Wtsi,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Rnaseh2btm1a(EUCOMM)Wtsi/Rnaseh2btm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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