ENSMUSG00000021973


Mus musculus

Features
Gene ID: ENSMUSG00000021973
  
Biological name :Micu2
  
Synonyms : Calcium uptake protein 2, mitochondrial / Micu2 / Q8CD10
  
Possible biological names infered from orthology : mitochondrial calcium uptake 2 / Q8IYU8
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C3
Gene start: 57916261
Gene end: 57999262
  
Corresponding Affymetrix probe sets: 10420457 (MoGene1.0st)   1454808_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022543
NCBI entrez gene - 68514     See in Manteia.
MGI - MGI:1915764
RefSeq - NM_028643
RefSeq - XM_006519484
RefSeq Peptide - NP_082919
swissprot - Q8CD10
Ensembl - ENSMUSG00000021973
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 micu2ENSDARG00000009939Danio rerio
 MICU2ENSGALG00000017125Gallus gallus
 MICU2ENSG00000165487Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Micu3 / Q9CTY5 / Calcium uptake protein 3, mitochondrial / Q86XE3* / mitochondrial calcium uptake family member 3*ENSMUSG0000003947839
Micu1 / Q8VCX5 / Mus musculus mitochondrial calcium uptake 1 (Micu1), transcript variant 4, mRNA. / Q9BPX6* / mitochondrial calcium uptake 1*ENSMUSG0000002011121


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006851 mitochondrial calcium ion transmembrane transport IEA
 biological_processGO:0036444 calcium import into the mitochondrion IEA
 biological_processGO:0051560 mitochondrial calcium ion homeostasis IEA
 biological_processGO:0051561 positive regulation of mitochondrial calcium ion concentration IMP
 biological_processGO:0051562 negative regulation of mitochondrial calcium ion concentration IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005758 mitochondrial intermembrane space ISO
 cellular_componentGO:0034704 calcium channel complex IDA
 cellular_componentGO:1990246 uniplex complex IEA
 molecular_functionGO:0005509 calcium ion binding IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Mitochondrial calcium ion transport
Processing of SMDT1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rorctm1.1Zsun/Rorctm1.1Zsun
Genetic Background: B6(129S4)-Rorctm1.1Zsun

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rorctm1.1Zsun/Rorctm1.1Zsun
Genetic Background: B6(129S4)-Rorctm1.1Zsun

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rorctm1.1Zsun/Rorctm1.1Zsun
Genetic Background: B6(129S4)-Rorctm1.1Zsun

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Rorctm1.1Zsun/Rorctm1.1Zsun
Genetic Background: B6(129S4)-Rorctm1.1Zsun

 MP:0008726 enlarged left atrium "increased size of the left upper chamber of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rorctm1.1Zsun/Rorctm1.1Zsun
Genetic Background: B6(129S4)-Rorctm1.1Zsun

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rorctm1.1Zsun/Rorctm1.1Zsun
Genetic Background: B6(129S4)-Rorctm1.1Zsun

 MP:0009870 abnormal abdominal aorta morphology "any structural anomaly of the part of the descending aorta that begins at the diaphragm and continues to the point of the common iliac arteries, and supplies oxygenated blood to all of the abdominal and pelvic organs and the legs" [http://www.medterms.com "MedicineNet.com"]
Show

Allelic Composition: Rorctm1.1Zsun/Rorctm1.1Zsun
Genetic Background: B6(129S4)-Rorctm1.1Zsun

 MP:0010659 abdominal aorta aneurysm "a protruding sac formed by the dilation of the wall of the part of the descending aorta that begins at the diaphragm and continues to the point of the common iliac arteries, resulting from a weakening of the vessel wall" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Rorctm1.1Zsun/Rorctm1.1Zsun
Genetic Background: B6(129S4)-Rorctm1.1Zsun

 MP:0011631 decreased mitochondria size "reduced size of the cellular organelles responsible for energy production" [MGI:csmith]
Show

Allelic Composition: Rorctm1.1Zsun/Rorctm1.1Zsun
Genetic Background: B6(129S4)-Rorctm1.1Zsun

 MP:0012557 decreased calcium uptake by cardiac muscle "decreased directed movement of calcium ions into cardiac muscle; decreased or disrupted uptake may give rise to energetic deficit and oxidative stress. leading to cardiac disease" [http://orcid.org/0000-0001-5208-3432, PMID:22902320]
Show

Allelic Composition: Rorctm1.1Zsun/Rorctm1.1Zsun
Genetic Background: B6(129S4)-Rorctm1.1Zsun

 MP:0020419 decreased cardiac muscle relaxation "inability or reduced ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [PMID:11565821, RGD:cur]
Show

Allelic Composition: Rorctm1.1Zsun/Rorctm1.1Zsun
Genetic Background: B6(129S4)-Rorctm1.1Zsun

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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