ENSMUSG00000022025


Mus musculus

Features
Gene ID: ENSMUSG00000022025
  
Biological name :Cnmd
  
Synonyms : Cnmd / Leukocyte cell-derived chemotaxin 1 Chondrosurfactant protein Chondromodulin-1 / Q9Z1F6
  
Possible biological names infered from orthology : chondromodulin / O75829
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: D3
Gene start: 79637690
Gene end: 79662170
  
Corresponding Affymetrix probe sets: 10421853 (MoGene1.0st)   1460258_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022603
Ensembl peptide - ENSMUSP00000126958
NCBI entrez gene - 16840     See in Manteia.
MGI - MGI:1341171
RefSeq - XM_006518665
RefSeq - NM_001310655
RefSeq - NM_010701
RefSeq - XM_006518663
RefSeq - XM_006518664
RefSeq Peptide - NP_001297584
RefSeq Peptide - NP_034831
swissprot - Q9Z1F6
swissprot - G5E8Z6
Ensembl - ENSMUSG00000022025
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cnmdENSDARG00000100133Danio rerio
 CNMDENSGALG00000016945Gallus gallus
 CNMDENSG00000136110Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tnmd / Q9EP64 / Tenomodulin / Q9H2S6*ENSMUSG0000003125035


Protein motifs (from Interpro)
Interpro ID Name
 IPR007084  BRICHOS domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001886 endothelial cell morphogenesis IDA
 biological_processGO:0001937 negative regulation of endothelial cell proliferation IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0016525 negative regulation of angiogenesis ISO
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway IMP
 biological_processGO:0051216 cartilage development IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Tbpl1tm1Saco/Tbpl1tm1Saco
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000064 failure of secondary bone resorption "inability of osteoclasts to degrade the organic and inorganic phases of bone by absorption" [J:67040, J:61295]
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Allelic Composition: Tbpl1tm1Saco/Tbpl1tm1Saco
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbpl1tm1Saco/Tbpl1tm1Saco
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001533 abnormal skeleton physiology "anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbpl1tm1Saco/Tbpl1tm1Saco
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: Tbpl1tm1Saco/Tbpl1tm1Saco
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbpl1tm1Saco/Tbpl1tm1Saco
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002966 decreased circulating alkaline phosphatase level "reduced activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbpl1tm1Saco/Tbpl1tm1Saco
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005006 abnormal osteoblast function "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbpl1tm1Saco/Tbpl1tm1Saco
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
Show

Allelic Composition: Tbpl1tm1Saco/Tbpl1tm1Saco
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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