ENSMUSG00000022174


Mus musculus

Features
Gene ID: ENSMUSG00000022174
  
Biological name :Dad1
  
Synonyms : Dad1 / Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 / P61804
  
Possible biological names infered from orthology : defender against cell death 1 / P61803
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C2
Gene start: 54235479
Gene end: 54254104
  
Corresponding Affymetrix probe sets: 10419736 (MoGene1.0st)   1418528_a_at (Mouse Genome 430 2.0 Array)   1454860_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022781
Ensembl peptide - ENSMUSP00000122366
NCBI entrez gene - 13135     See in Manteia.
MGI - MGI:101912
RefSeq - NM_001113358
RefSeq - NM_010015
RefSeq Peptide - NP_001106829
RefSeq Peptide - NP_034145
swissprot - P61804
Ensembl - ENSMUSG00000022174
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dad1ENSDARG00000102105Danio rerio
 DAD1ENSGALG00000035626Gallus gallus
 DAD1ENSG00000129562Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003038  DAD/Ost2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001824 blastocyst development IMP
 biological_processGO:0006486 protein glycosylation ISS
 biological_processGO:0006487 protein N-linked glycosylation IBA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0008250 oligosaccharyltransferase complex IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004576 oligosaccharyl transferase activity IBA
 molecular_functionGO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fzd9tm1Sjp/Fzd9+
Genetic Background: involves: C57BL/6J

 MP:0001674 abnormal triploblastic development "abnormal development of the three primary germ layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf8tm2Moon/Fgf8tm1Mrc,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129S/Sv

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf8tm2Moon/Fgf8tm1Mrc,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129S/Sv

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Fgf8tm2Moon/Fgf8tm1Mrc,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129S/Sv

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
Show

Allelic Composition: Fgf8tm2Moon/Fgf8tm1Mrc,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129S/Sv

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf8tm2Moon/Fgf8tm1Mrc,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129S/Sv

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgf8tm2Moon/Fgf8tm1Mrc,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129S/Sv

 MP:0002718 abnormal inner cell mass "malformed or absent cells of the blastocyst that develop into the body of the embryo" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Wnt1tm1Brd/Wnt1tm1Brd,Wnt4tm1Amc/Wnt4tm1Amc
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

 MP:0002824 abnormal chorioallantoic fusion "abnormal process of or failure of the formation of the membrane that forms the fetal portion of the placenta; derived from the fusion of the chorion and the allantois" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf8tm2Moon/Fgf8tm1Mrc,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129S/Sv

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fzd9tm1Sjp/Fzd9+
Genetic Background: involves: C57BL/6J

Allelic Composition: Dad1tm1Kni/Dad1+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Dad1tm1Wnt/Dad1tm1Wnt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004073 caudal body truncation "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dad1tm1Wnt/Dad1tm1Wnt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004956 decreased thymus weight "reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dad1tm1Kni/Dad1+
Genetic Background: involves: 129S/SvEv

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf8tm2Moon/Fgf8tm1Mrc,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129S/Sv

 MP:0010380 inner cell mass apoptosis "the cells of the blastocyst that develop into the body of the embryo are undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wnt1tm1Brd/Wnt1tm1Brd,Wnt4tm1Amc/Wnt4tm1Amc
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Fzd9tm1Sjp/Fzd9+
Genetic Background: involves: C57BL/6J

Allelic Composition: Dad1tm1Brw/Dad1tm1Brw
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Dad1tm1Wnt/Dad1tm1Wnt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011106 partial embryonic lethality before somite formation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Dad1tm1Kni/Dad1+
Genetic Background: involves: 129S/SvEv

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
Show

Allelic Composition: Dad1tm1Wnt/Dad1tm1Wnt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011187 abnormal parietal endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue that lines the luminal surface of the mural trophectoderm" [PMID:19201946]
Show

Allelic Composition: Dad1tm1Wnt/Dad1tm1Wnt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011197 abnormal proamniotic cavity morphology "any structural anomaly of the cavity of the developing embryo that is formed within the epiblast tissue prior to the closing of the proamniotic canal by the amniotic folds" [ISBN:0-12-402035-6]
Show

Allelic Composition: Dad1tm1Wnt/Dad1tm1Wnt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011200 abnormal extraembryonic coelom morphology "any structural anomaly of the fluid-filled spaces formed within the mass of extraembryonic mesoderm that later fuse to become a large extraembryonic cavity" [ISBN:0-12-402035-6, ISBN-10:1405118660]
Show

Allelic Composition: Dad1tm1Wnt/Dad1tm1Wnt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0012095 increased Reichert s membrane thickness "increased width of the extraembryonic basement membrane that forms on the inner surface of the trophectoderm during placenta morphogenesis and is secreted by the distal parietal endoderm" [MGI:anna]
Show

Allelic Composition: Dad1tm1Wnt/Dad1tm1Wnt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0012299 hydropic allantois "excessive accumulation of fluid within the allantoic sac" [MGI:anna]
Show

Allelic Composition: Dad1tm1Wnt/Dad1tm1Wnt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Dad1tm1Brw/Dad1tm1Brw
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Dad1tm1Wnt/Dad1tm1Wnt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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