ENSMUSG00000022369


Mus musculus

Features
Gene ID: ENSMUSG00000022369
  
Biological name :Mtbp
  
Synonyms : Mdm2-binding protein / Mtbp / Q8BJS8
  
Possible biological names infered from orthology : Q96DY7
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: D1
Gene start: 55557408
Gene end: 55626423
  
Corresponding Affymetrix probe sets: 10424188 (MoGene1.0st)   1448638_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022998
Ensembl peptide - ENSMUSP00000128615
Ensembl peptide - ENSMUSP00000129396
Ensembl peptide - ENSMUSP00000131887
NCBI entrez gene - 105837     See in Manteia.
MGI - MGI:2146005
RefSeq - XM_017316361
RefSeq - NM_001168250
RefSeq - NM_134092
RefSeq - XM_006520250
RefSeq - XM_011245394
RefSeq - XM_017316360
RefSeq Peptide - NP_001161722
RefSeq Peptide - NP_598853
swissprot - F6ZKA0
swissprot - Q8BJS8
Ensembl - ENSMUSG00000022369
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mtbpENSDARG00000090447Danio rerio
 MTBPENSGALG00000031524Gallus gallus
 MTBPENSG00000172167Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR029418  MDN2-binding protein, C-terminal domain
 IPR029420  MDM2-binding protein, central domain
 IPR029421  MDM2-binding protein, N-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007089 traversing start control point of mitotic cell cycle IDA
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0034501 protein localization to kinetochore ISO
 biological_processGO:0045839 negative regulation of mitotic nuclear division IDA
 cellular_componentGO:0000776 kinetochore ISO
 cellular_componentGO:0000785 chromatin ISO
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001272 increased metastatic potential 
Show

Allelic Composition: Mtbptm1Glo/Mtbp+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Mtbptm1Glo/Mtbp+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Mtbptm1Glo/Mtbp+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mtbptm1Glo/Mtbptm1Glo,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Genetic Background: B6.129-Bcl2l11tm1.1Ast/J

Allelic Composition: Mtbptm1Glo/Mtbptm1Glo,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Mtbptm1Glo/Mtbptm1Glo,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Mtbptm1Glo/Mtbp+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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