ENSMUSG00000022378


Mus musculus

Features
Gene ID: ENSMUSG00000022378
  
Biological name :Fam49b
  
Synonyms : Fam49b / Protein FAM49B / Q921M7
  
Possible biological names infered from orthology : family with sequence similarity 49 member B / Q9NUQ9
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: D1
Gene start: 63929097
Gene end: 64060478
  
Corresponding Affymetrix probe sets: 10428983 (MoGene1.0st)   1423829_at (Mouse Genome 430 2.0 Array)   1436088_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000066359
Ensembl peptide - ENSMUSP00000154320
Ensembl peptide - ENSMUSP00000154547
Ensembl peptide - ENSMUSP00000132486
Ensembl peptide - ENSMUSP00000153790
Ensembl peptide - ENSMUSP00000154205
NCBI entrez gene - 223601     See in Manteia.
MGI - MGI:1923520
RefSeq - XM_017316550
RefSeq - NM_144846
RefSeq - XM_011245564
RefSeq - XM_011245565
RefSeq - XM_006520761
RefSeq - XM_006520762
RefSeq - XM_006520763
RefSeq - XM_006520764
RefSeq - XM_006520765
RefSeq - XM_006520766
RefSeq - XM_011245563
RefSeq Peptide - NP_659095
swissprot - Q921M7
Ensembl - ENSMUSG00000022378
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fam49bbENSDARG00000045417Danio rerio
 FAM49BENSGALG00000036490Gallus gallus
 FAM49BENSG00000153310Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fam49a / Q8BHZ0 / Protein FAM49A / Q9H0Q0* / family with sequence similarity 49 member A*ENSMUSG0000002058979


Protein motifs (from Interpro)
Interpro ID Name
 IPR009828  Protein of unknown function DUF1394


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001916 positive regulation of T cell mediated cytotoxicity IDA
 biological_processGO:0032729 positive regulation of interferon-gamma production IDA
 biological_processGO:0050870 positive regulation of T cell activation IDA
 biological_processGO:2000568 positive regulation of memory T cell activation IDA
 cellular_componentGO:0005929 cilium IDA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0023030 MHC class Ib protein binding, via antigen binding groove IDA


Pathways (from Reactome)
Pathway description
Platelet degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faddtm1e.1(KOMP)Wtsi/Faddtm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Faddtm1e.1(KOMP)Wtsi/Ucd

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Faddtm1e.1(KOMP)Wtsi/Faddtm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Faddtm1e.1(KOMP)Wtsi/Ucd

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Faddtm1e.1(KOMP)Wtsi/Faddtm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Faddtm1e.1(KOMP)Wtsi/Ucd

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Faddtm1e.1(KOMP)Wtsi/Faddtm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Faddtm1e.1(KOMP)Wtsi/Ucd

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Faddtm1e.1(KOMP)Wtsi/Faddtm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Faddtm1e.1(KOMP)Wtsi/Ucd

 MP:0005634 decreased circulating sodium level "less than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Faddtm1e.1(KOMP)Wtsi/Faddtm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Faddtm1e.1(KOMP)Wtsi/Ucd

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Faddtm1e.1(KOMP)Wtsi/Faddtm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Faddtm1e.1(KOMP)Wtsi/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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