ENSMUSG00000022422


Mus musculus

Features
Gene ID: ENSMUSG00000022422
  
Biological name :Dscc1
  
Synonyms : Dscc1 / Mus musculus DNA replication and sister chromatid cohesion 1 (Dscc1), transcript variant 1, mRNA. / Q14AI0
  
Possible biological names infered from orthology : DNA replication and sister chromatid cohesion 1 / Q9BVC3
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: D1
Gene start: 55076099
Gene end: 55090491
  
Corresponding Affymetrix probe sets: 10428672 (MoGene1.0st)   1436583_at (Mouse Genome 430 2.0 Array)   1452912_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023059
Ensembl peptide - ENSMUSP00000105860
NCBI entrez gene - 72107     See in Manteia.
MGI - MGI:1919357
RefSeq - XM_017316754
RefSeq - NM_001355594
RefSeq - NM_183089
RefSeq Peptide - NP_001342523
RefSeq Peptide - NP_898912
swissprot - Q14AI0
swissprot - D3YVY9
Ensembl - ENSMUSG00000022422
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dscc1ENSDARG00000019907Danio rerio
 DSCC1ENSGALG00000043799Gallus gallus
 DSCC1ENSG00000136982Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR019128  Sister chromatid cohesion protein Dcc1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006275 regulation of DNA replication IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007064 mitotic sister chromatid cohesion IEA
 biological_processGO:0034088 maintenance of mitotic sister chromatid cohesion IEA
 biological_processGO:0034421 post-translational protein acetylation IEA
 biological_processGO:1900264 positive regulation of DNA-directed DNA polymerase activity IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0031390 Ctf18 RFC-like complex IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003689 DNA clamp loader activity IEA
 molecular_functionGO:0043142 single-stranded DNA-dependent ATPase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Kat14tm1a(KOMP)Wtsi/Kat14tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kat14tm1a(KOMP)Wtsi/Wtsi

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Kat14tm1a(KOMP)Wtsi/Kat14tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kat14tm1a(KOMP)Wtsi/Wtsi

 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Kat14tm1a(KOMP)Wtsi/Kat14tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kat14tm1a(KOMP)Wtsi/Wtsi

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Kat14tm1a(KOMP)Wtsi/Kat14tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kat14tm1a(KOMP)Wtsi/Wtsi

 MP:0004609 vertebral fusion "the union of one or more vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kat14tm1a(KOMP)Wtsi/Kat14tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kat14tm1a(KOMP)Wtsi/Wtsi

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Kat14tm1a(KOMP)Wtsi/Kat14tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kat14tm1a(KOMP)Wtsi/Wtsi

 MP:0004651 increased thoracic vertebrae number "increased number of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Kat14tm1a(KOMP)Wtsi/Kat14tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kat14tm1a(KOMP)Wtsi/Wtsi

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kat14tm1a(KOMP)Wtsi/Kat14tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kat14tm1a(KOMP)Wtsi/Wtsi

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kat14tm1a(KOMP)Wtsi/Kat14tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kat14tm1a(KOMP)Wtsi/Wtsi

 MP:0010101 increased sacral vertebrae number "increase of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kat14tm1a(KOMP)Wtsi/Kat14tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kat14tm1a(KOMP)Wtsi/Wtsi

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kat14tm1a(KOMP)Wtsi/Kat14tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kat14tm1a(KOMP)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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