ENSMUSG00000022468


Mus musculus

Features
Gene ID: ENSMUSG00000022468
  
Biological name :Endou
  
Synonyms : Endou / Poly(U)-specific endoribonuclease / Q3V188
  
Possible biological names infered from orthology : endonuclease, poly(U) specific / P21128
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: F1
Gene start: 97711015
Gene end: 97731339
  
Corresponding Affymetrix probe sets: 10431962 (MoGene1.0st)   1449937_at (Mouse Genome 430 2.0 Array)   1449938_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023105
Ensembl peptide - ENSMUSP00000097820
Ensembl peptide - ENSMUSP00000155246
NCBI entrez gene - 19011     See in Manteia.
MGI - MGI:97746
RefSeq - XM_017316511
RefSeq - NM_001168693
RefSeq - NM_008902
RefSeq - XM_006520617
RefSeq - XM_006520618
RefSeq Peptide - NP_001162164
RefSeq Peptide - NP_032928
swissprot - Q3V188
Ensembl - ENSMUSG00000022468
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 endouENSDARG00000044204Danio rerio
 ENDOUENSGALG00000039970Gallus gallus
 ENDOUENSG00000111405Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001212  Somatomedin B domain
 IPR018998  EndoU ribonuclease family
 IPR020436  Somatomedin B, chordata
 IPR036024  Somatomedin B-like domain superfamily
 IPR037227  Endoribonuclease EndoU-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis ISO
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007565 female pregnancy ISS
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005737 cytoplasm ISS
 molecular_functionGO:0003723 RNA binding ISO
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004521 endoribonuclease activity ISO
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity ISS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030247 polysaccharide binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egr1tm1b(NCOM)Mfgc/Egr1tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Egr1tm1b(NCOM)Mfgc/Tcp

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Cd22tm2Tft/Cd22tm2Tft
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010675 decreased activation-induced B cell apoptosis "decreased frequency of B cell apoptosis that occurs upon engagement of either the B cell receptor or CD40, but not both; the engagement leads to expression of fas or related receptors that make the B cell susceptible to fas-ligand mediated death" [PMID:11032170]
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Allelic Composition: Cd22tm2Tft/Cd22tm2Tft
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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