ENSMUSG00000022596


Mus musculus

Features
Gene ID: ENSMUSG00000022596
  
Biological name :Slurp1
  
Synonyms : Q9Z0K7 / Secreted Ly-6/uPAR-related protein 1 / Slurp1
  
Possible biological names infered from orthology : P55000 / secreted LY6/PLAUR domain containing 1
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: D3
Gene start: 74724318
Gene end: 74728034
  
Corresponding Affymetrix probe sets: 10429500 (MoGene1.0st)   1420562_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141013
Ensembl peptide - ENSMUSP00000023261
NCBI entrez gene - 57277     See in Manteia.
MGI - MGI:1930923
RefSeq - NM_020519
RefSeq Peptide - NP_065265
swissprot - A0A0A0MQ72
swissprot - Q9Z0K7
Ensembl - ENSMUSG00000022596
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000046632Gallus gallus
 P55000ENSG00000126233Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lypd2 / Q9DD23 / Ly6/PLAUR domain-containing protein 2 / Q6UXB3* / LY6/PLAUR domain containing 2*ENSMUSG0000002259539


Protein motifs (from Interpro)
Interpro ID Name
 IPR016054  Ly-6 antigen/uPA receptor-like
 IPR018363  CD59 antigen, conserved site
 IPR027103  Secreted Ly-6/uPAR-related protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001775 cell activation IBA
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010839 negative regulation of keratinocyte proliferation IMP
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0038195 urokinase plasminogen activator signaling pathway IEA
 biological_processGO:0050884 neuromuscular process controlling posture IMP
 biological_processGO:2000273 positive regulation of signaling receptor activity IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030549 acetylcholine receptor activator activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: involves: CD-1

Allelic Composition: Slurp1tm1.1Sgy/Slurp1tm1.1Sgy
Genetic Background: involves: 129 * C57BL/6

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
Show

Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: involves: CD-1

Allelic Composition: Slurp1tm1.1Sgy/Slurp1tm1.1Sgy
Genetic Background: involves: 129 * C57BL/6

 MP:0001239 abnormal granular layer morphology "structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: involves: CD-1

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: involves: CD-1

Allelic Composition: Slurp1tm1.1Sgy/Slurp1tm1.1Sgy
Genetic Background: involves: 129 * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: involves: CD-1

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Slurp1tm1.1Sgy/Slurp1tm1.1Sgy
Genetic Background: involves: 129 * C57BL/6

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: involves: CD-1

Allelic Composition: Slurp1tm1.1Sgy/Slurp1tm1.1Sgy
Genetic Background: involves: 129 * C57BL/6

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: involves: CD-1

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: involves: CD-1

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
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Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: involves: CD-1

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: involves: CD-1

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: involves: CD-1

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: involves: CD-1

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: involves: CD-1

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: involves: CD-1

 MP:0008963 increased carbon dioxide production "increase in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: involves: CD-1

 MP:0009583 increased keratinocyte proliferation "increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: involves: CD-1

 MP:0009596 abnormal stratum corneum lipid matrix formation "altered lipid composition or intercellular lipid matrix assembly in the stratum corneum, usually resulting in loss of epidermal barrier function; normally, the intercorneocyte lipid matrix consists of a complex lipid mixture of ceramides, cholesterol and long-chain saturated fatty acids that self-assembles into an ordered multilayer structure known as lipid lamellae" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: involves: CD-1

Allelic Composition: Slurp1tm1.1Sgy/Slurp1tm1.1Sgy
Genetic Background: involves: 129 * C57BL/6

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: involves: CD-1

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: involves: CD-1

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Ptentm1Engc/Ptentm1Engc
Genetic Background: involves: CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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