ENSMUSG00000022602


Mus musculus

Features
Gene ID: ENSMUSG00000022602
  
Biological name :Arc
  
Synonyms : Activity-regulated cytoskeleton-associated protein / Arc / Q9WV31
  
Possible biological names infered from orthology : Q7LC44
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: D3
Gene start: 74669083
Gene end: 74672570
  
Corresponding Affymetrix probe sets: 10429491 (MoGene1.0st)   1418687_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023268
Ensembl peptide - ENSMUSP00000105636
NCBI entrez gene - 11838     See in Manteia.
MGI - MGI:88067
RefSeq - NM_001276684
RefSeq - NM_018790
RefSeq Peptide - NP_001263613
RefSeq Peptide - NP_061260
swissprot - Q9WV31
Ensembl - ENSMUSG00000022602
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ARCENSGALG00000016154Gallus gallus
 ARCENSG00000198576Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR023263  Activity-regulated cytoskeleton-associated protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0007010 cytoskeleton organization ISO
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007492 endoderm development IMP
 biological_processGO:0007612 learning IEA
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0016477 cell migration ISS
 biological_processGO:0022604 regulation of cell morphogenesis ISO
 biological_processGO:0048168 regulation of neuronal synaptic plasticity IEA
 biological_processGO:0061001 regulation of dendritic spine morphogenesis IEA
 biological_processGO:1900271 regulation of long-term synaptic potentiation IEA
 biological_processGO:2000969 positive regulation of AMPA receptor activity IEA
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005856 cytoskeleton TAS
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0003779 actin binding TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Fbxl3Gt(FHCRC-GT-S13-12G1)Sor/Fbxl3Ovtm
Genetic Background: involves: BTBR/J * C3H/HeJ * C57BL/6J

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Fbxl3Gt(FHCRC-GT-S13-12G1)Sor/Fbxl3Ovtm
Genetic Background: involves: BTBR/J * C3H/HeJ * C57BL/6J

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Fbxl3Gt(FHCRC-GT-S13-12G1)Sor/Fbxl3Ovtm
Genetic Background: involves: BTBR/J * C3H/HeJ * C57BL/6J

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Fbxl3Gt(FHCRC-GT-S13-12G1)Sor/Fbxl3Ovtm
Genetic Background: involves: BTBR/J * C3H/HeJ * C57BL/6J

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Araftm1Mmc/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
Show

Allelic Composition: Araftm1Mmc/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001696 failure to gastrulate "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]
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Allelic Composition: Araftm1Mmc/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001705 abnormal proximal-distal axis patterning "anomaly in the formation or development of a body structure, often a limb, in relation to the structure s proximity to the trunk or point of origin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Araftm1Mmc/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Araftm1Mmc/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

 MP:0002582 disorganized extraembryonic tissue "a lack of the regular arrangement of the membranes involved with the embryo s protection and nutrition" [J:40596, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Araftm1Mmc/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002801 abnormal long-term recognition memory "defects in long-term memory for objects that is consolidated over hours and days after training." [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Fbxl3Gt(FHCRC-GT-S13-12G1)Sor/Fbxl3Ovtm
Genetic Background: involves: BTBR/J * C3H/HeJ * C57BL/6J

 MP:0002805 abnormal conditioned taste aversion behavior "a defect in the ability of an animal to learn to avoid food sources that were previously associated with aversive internal stimuli or sickness such as a drug that induces sickness " [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Fbxl3Gt(FHCRC-GT-S13-12G1)Sor/Fbxl3Ovtm
Genetic Background: involves: BTBR/J * C3H/HeJ * C57BL/6J

 MP:0002885 abnormal AMPA-mediated synaptic currents "change in the measured amplitude or duration of response to stimulation of AMPA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fbxl3Gt(FHCRC-GT-S13-12G1)Sor/Fbxl3Ovtm
Genetic Background: involves: BTBR/J * C3H/HeJ * C57BL/6J

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
Show

Allelic Composition: Fbxl3Gt(FHCRC-GT-S13-12G1)Sor/Fbxl3Ovtm
Genetic Background: involves: BTBR/J * C3H/HeJ * C57BL/6J

 MP:0003460 decreased fear-related response "reduced emotional response related to anticipation of specific pain or danger" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Fbxl3Gt(FHCRC-GT-S13-12G1)Sor/Fbxl3Ovtm
Genetic Background: involves: BTBR/J * C3H/HeJ * C57BL/6J

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

 MP:0003890 abnormal embryonic-extraembryonic boundary morphology "anomaly in the normal development /maintenance of the connection between the embryo proper and extraembryonic tissues" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Araftm1Mmc/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Araftm1Mmc/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003988 disorganized embryonic tissue "a lack of the regular arrangement of any embryonic tissues" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:58080]
Show

Allelic Composition: Araftm1Mmc/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004264 abnormal extraembryonic tissue physiology "functional anomaly of the membranes involved with embryonic protection and nutrition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Araftm1Mmc/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fbxl3Gt(FHCRC-GT-S13-12G1)Sor/Fbxl3Ovtm
Genetic Background: involves: BTBR/J * C3H/HeJ * C57BL/6J

 MP:0010736 abnormal extraembryonic ectoderm morphology "any structural anomaly of the layer of the ectoderm of the extraembryonic tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Araftm1Mmc/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Araftm1Mmc/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
Show

Allelic Composition: Araftm1Mmc/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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