ENSMUSG00000022718


Mus musculus

Features
Gene ID: ENSMUSG00000022718
  
Biological name :Dgcr8
  
Synonyms : Dgcr8 / Microprocessor complex subunit DGCR8 / Q9EQM6
  
Possible biological names infered from orthology : DGCR8, microprocessor complex subunit / Q8WYQ5
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: A3
Gene start: 18253948
Gene end: 18289249
  
Corresponding Affymetrix probe sets: 10438313 (MoGene1.0st)   1422981_at (Mouse Genome 430 2.0 Array)   1435439_at (Mouse Genome 430 2.0 Array)   1446169_at (Mouse Genome 430 2.0 Array)   1455311_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000009321
Ensembl peptide - ENSMUSP00000111296
NCBI entrez gene - 94223     See in Manteia.
MGI - MGI:2151114
RefSeq - XM_017317176
RefSeq - NM_033324
RefSeq - XM_006522795
RefSeq Peptide - NP_201581
swissprot - Q9EQM6
Ensembl - ENSMUSG00000022718
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dgcr8ENSDARG00000035564Danio rerio
 DGCR8ENSGALG00000033126Gallus gallus
 DGCR8ENSG00000128191Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001202  WW domain
 IPR014720  Double-stranded RNA-binding domain
 IPR036020  WW domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0031053 primary miRNA processing IEA
 biological_processGO:0072091 regulation of stem cell proliferation IMP
 biological_processGO:0090501 RNA phosphodiester bond hydrolysis IEA
 biological_processGO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0070877 microprocessor complex IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0004525 ribonuclease III activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070878 primary miRNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0001447 abnormal nest building behavior "deviation from the usual behavior of mice to build sleeping nests out of any available materials; also of female mice to bulid nests to protect offspring" [J:42758, What s wrong with my mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Dgcr8Gt(XG058)Byg/Dgcr8Gt(XG058)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0002573 behavioral despair "depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli" [J:80395]
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Allelic Composition: Dgcr8Gt(XG058)Byg/Dgcr8Gt(XG058)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
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Allelic Composition: Fgfr2tm3Ewj/Fgfr2+
Genetic Background: B6.129-Fgfr2tm3Ewj

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0003896 prolonged PQ interval "increase in the length of time between the beginning of atrial depolarisation and the beginning of ventricular depolarisation" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0004101 abnormal brain interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the brain; this includes most brain neuronal cell types" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ampd2tm1Tm/Ampd2tm1Tm,Ampd3tm2a(KOMP)Wtsi/Ampd3tm2a(KOMP)Wtsi
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dgcr8Gt(XG058)Byg/Dgcr8Gt(XG058)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ampd2tm1Tm/Ampd2tm1Tm,Ampd3tm2a(KOMP)Wtsi/Ampd3tm2a(KOMP)Wtsi
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Ranbp2tm1Jvd/Ranbp2tm1Jvd
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Dgcr8Gt(XH157)Byg/Dgcr8+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dgcr8Gt(XH157)Byg/Dgcr8+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Dgcr8Gt(XG058)Byg/Dgcr8+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dgcr8Gt(XH157)Byg/Dgcr8+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010392 prolonged QRS complex duration "increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Dhcr7tm1Gst/Dhcr7tm1Gst,Tg(APOE-DHCR7)2Hoyu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL * C57BL/6J * FVB/N

Allelic Composition: Dgcr8Gt(XG058)Byg/Dgcr8Gt(XG058)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012307 impaired spatial learning "impaired ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]
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Allelic Composition: Dgcr8Gt(XG058)Byg/Dgcr8+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012460 decreased dentate gyrus size "reduced size of one of two interlocking gyri of the hippocampus formation that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [MGI:csmith]
Show

Allelic Composition: Ampd2tm1Tm/Ampd2tm1Tm,Ampd3tm2a(KOMP)Wtsi/Ampd3tm2a(KOMP)Wtsi
Genetic Background: involves: 129S2/SvPas * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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