ENSMUSG00000022749


Mus musculus

Features
Gene ID: ENSMUSG00000022749
  
Biological name :Tbc1d23
  
Synonyms : Q8K0F1 / Tbc1d23 / TBC1 domain family member 23
  
Possible biological names infered from orthology : Q9NUY8
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: C1.1
Gene start: 57168862
Gene end: 57231504
  
Corresponding Affymetrix probe sets: 10440050 (MoGene1.0st)   1426899_at (Mouse Genome 430 2.0 Array)   1439090_at (Mouse Genome 430 2.0 Array)   1452228_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023431
Ensembl peptide - ENSMUSP00000153899
Ensembl peptide - ENSMUSP00000154535
NCBI entrez gene - 67581     See in Manteia.
MGI - MGI:1914831
RefSeq - XM_017317122
RefSeq - NM_026254
RefSeq - XM_006522484
RefSeq - XM_006522485
RefSeq - XM_006522486
RefSeq Peptide - NP_080530
RefSeq Peptide - NP_001345362
swissprot - Q8K0F1
Ensembl - ENSMUSG00000022749
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tbc1d23ENSDARG00000044357Danio rerio
 TBC1D23ENSGALG00000015273Gallus gallus
 Q9NUY8ENSG00000036054Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000195  Rab-GTPase-TBC domain
 IPR001763  Rhodanese-like domain
 IPR035969  Rab-GTPase-TBC domain superfamily
 IPR036873  Rhodanese-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0016192 vesicle-mediated transport IMP
 biological_processGO:0031175 neuron projection development IMP
 biological_processGO:0032680 regulation of tumor necrosis factor production IMP
 biological_processGO:0032755 positive regulation of interleukin-6 production IMP
 biological_processGO:0042147 retrograde transport, endosome to Golgi IEA
 biological_processGO:0050727 regulation of inflammatory response IMP
 biological_processGO:1990403 embryonic brain development IMP
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0071203 WASH complex IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Runx1tm2.1(cre/Esr1*)Ims/Runx1tm2.1(cre/Esr1*)Ims
Genetic Background: involves: C57BL/6

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Runx1tm2.1(cre/Esr1*)Ims/Runx1tm2.1(cre/Esr1*)Ims
Genetic Background: involves: C57BL/6

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Runx1tm2.1(cre/Esr1*)Ims/Runx1tm2.1(cre/Esr1*)Ims
Genetic Background: involves: C57BL/6

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Runx1tm2.1(cre/Esr1*)Ims/Runx1tm2.1(cre/Esr1*)Ims
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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