ENSMUSG00000022783


Mus musculus

Features
Gene ID: ENSMUSG00000022783
  
Biological name :Spag6
  
Synonyms : Q9JLI7 / Spag6 / Sperm-associated antigen 6
  
Possible biological names infered from orthology : O75602
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: A3
Gene start: 16753016
Gene end: 16829456
  
Corresponding Affymetrix probe sets: 10345698 (MoGene1.0st)   10357478 (MoGene1.0st)   10400334 (MoGene1.0st)   10401924 (MoGene1.0st)   10431656 (MoGene1.0st)   10438049 (MoGene1.0st)   10447286 (MoGene1.0st)   10500009 (MoGene1.0st)   10509275 (MoGene1.0st)   1417528_at (Mouse Genome 430 2.0 Array)   1428212_x_at (Mouse Genome 430 2.0 Array)   1436924_x_at (Mouse Genome 430 2.0 Array)   1460008_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023468
NCBI entrez gene - 50525     See in Manteia.
MGI - MGI:1354388
RefSeq - XM_017317063
RefSeq - NM_015773
RefSeq Peptide - NP_056588
swissprot - Q497N2
swissprot - Q9JLI7
Ensembl - ENSMUSG00000022783
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 spag6ENSDARG00000020158Danio rerio
 SPAG6ENSGALG00000007892Gallus gallus
 SPAG6ENSG00000077327Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Spag6 / O75602* / sperm associated antigen 6*ENSMUSG0000003770893


Protein motifs (from Interpro)
Interpro ID Name
 IPR000225  Armadillo
 IPR000357  HEAT repeat
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007288 sperm axoneme assembly IMP
 biological_processGO:0021591 ventricular system development IMP
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0030317 flagellated sperm motility IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0015630 microtubule cytoskeleton ISO
 cellular_componentGO:0031514 motile cilium IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0097228 sperm principal piece IDA
 cellular_componentGO:1990716 axonemal central apparatus IGI
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000434 megacephaly "an abnormally large size of the head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
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Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000827 dilated third ventricle "enlarged narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Spag6ltm1Jfs/Spag6l+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008892 abnormal sperm flagellum "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009234 absent sperm head "absence of the head segment of the sperm cell" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009239 short sperm flagellum "decreased length of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009831 abnormal sperm midpiece morphology "any structural abnormality of the highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece" [PMID:14581499]
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009836 abnormal sperm principal piece morphology "any structural abnormality in the segment of the sperm flagellum where the mitochondrial sheath ends and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs; the principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece" [PMID:14581499]
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009838 abnormal sperm axoneme morphology "any structural abnormality of the central core of the sperm flagellum, composed of a ring of 9 outer microtubule doublets surrounding a central pair; inner and outer dynein arms project from each of the outer 9 doublets, and these arms are responsible for generating the motive force of the flagellum; in addition, 9 radial spokes, each of which originates from 1 of the 9 outer microtubular doublet pairs, project inward toward the central pair in a helical fashion" [PMID:14581499]
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2tm1Lht
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

2 s.

 
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