Manteia - Molecule gene

ENSMUSG00000022816

Mus musculus

Features

Gene ID:	ENSMUSG00000022816

Biological name :	Fstl1

Synonyms :	Follistatin-related protein 1 / Fstl1 / Q62356

Possible biological names infered from orthology :	follistatin like 1 / Q12841

Species:	Mus musculus

Chr. number:	16
Strand:	1
Band:	B3
Gene start:	37776873
Gene end:	37836514

Corresponding Affymetrix probe sets:	10435641 (MoGene1.0st) 1416221_at (Mouse Genome 430 2.0 Array) 1439191_at (Mouse Genome 430 2.0 Array) 1448259_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000110411 NCBI entrez gene - 14314 See in Manteia. MGI - MGI:102793 RefSeq - NM_008047 RefSeq Peptide - NP_032073 swissprot - Q62356 Ensembl - ENSMUSG00000022816

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
fstl1a	ENSDARG00000015559	Danio rerio
fstl1b	ENSDARG00000039576	Danio rerio
FSTL1	ENSGALG00000014970	Gallus gallus
FSTL1	ENSG00000163430	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Fstl5 / Q8BFR2 / Follistatin-related protein 5 / Q8N475* / follistatin like 5*	ENSMUSG00000034098	28
Fstl4 / Q5STE3 / Follistatin-related protein 4 / Q6MZW2* / follistatin like 4*	ENSMUSG00000036264	25

Protein motifs (from Interpro)

Interpro ID	Name
IPR002048	EF-hand domain
IPR002350	Kazal domain
IPR003645	Follistatin-like, N-terminal
IPR011992	EF-hand domain pair
IPR015369	Follistatin/Osteonectin EGF domain
IPR036058	Kazal domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0042594	response to starvation	IDA
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005615	extracellular space	IDA
molecular_function	GO:0005509	calcium ion binding	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008201	heparin binding	IEA

Pathways (from Reactome)

Pathway description

Signaling by BMP

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Post-translational protein phosphorylation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000150	abnormal rib morphology	"malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]	Show Allelic Composition: Arntl^tm1Bra/Arntl^tm1Weit,Syt10^{tm1.1(icre)Geno}/Syt10^{tm1.1(icre)Geno} Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 Allelic Composition: Fstl1^tm1.2Mvdh/Fstl1⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB Allelic Composition: Fstl1^{tm2.1(cre/ERT2)Mvdh}/Fstl1^{tm2.1(cre/ERT2)Mvdh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Fstl1^{tm2.1(cre/ERT2)Mvdh}/Fstl1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000519	hydronephrosis	"dilation of the pelvis and calices of one or both kidneys" [J:56641]	Show Allelic Composition: Bax^tm1Sjk/Bax^tm1Sjk,Pcdhg^tm1.1Tman/Pcdhg^tm1.1Tman Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0000534	abnormal ureter morphology	"anomalous structure of the tube that conducts the urine from the renal pelvis to the bladder" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Bax^tm1Sjk/Bax^tm1Sjk,Pcdhg^tm1.1Tman/Pcdhg^tm1.1Tman Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0000536	hydroureter	"distention of the ureter with urine, due to blockage from any cause" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:Cml, J:13044]	Show Allelic Composition: Otof^tm1.1Erei/Otof^tm1.1Erei Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fstl1^tm1.1Nju/Fstl1^tm1.1Nju Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0000961	abnormal dorsal root ganglia morphology	"malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]	Show Allelic Composition: Fstl1^tm1.1Nju/Fstl1^tm1.1Nju Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0001175	abnormal lung morphology	"malformed organ of respiration" [J:35802]	Show Allelic Composition: Otof^tm1.1Erei/Otof^tm1.1Erei Genetic Background: involves: 129P2/OlaHsd
MP:0001176	abnormal lung development	"malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Otof^tm1.1Erei/Otof^tm1.1Erei Genetic Background: involves: 129P2/OlaHsd
MP:0001575	cyanosis	"a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]	Show Allelic Composition: Otof^tm1.1Erei/Otof^tm1.1Erei Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fstl1^tm1.2Mvdh/Fstl1^tm1.2Mvdh Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB Allelic Composition: Fstl1^{tm2.1(cre/ERT2)Mvdh}/Fstl1^{tm2.1(cre/ERT2)Mvdh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001625	cardiac hypertrophy	"an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Cd68^tm1Xfen/Cd68⁺ Genetic Background: C57BL/6J-Cd68^tm1Xfen
MP:0001951	abnormal breathing	"irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]	Show Allelic Composition: Otof^tm1.1Erei/Otof^tm1.1Erei Genetic Background: involves: 129P2/OlaHsd
MP:0001954	respiratory distress	"physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Fstl1^tm1.2Mvdh/Fstl1^tm1.2Mvdh Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB Allelic Composition: Fstl1^{tm2.1(cre/ERT2)Mvdh}/Fstl1^{tm2.1(cre/ERT2)Mvdh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002110	abnormal digit morphology	"abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Arntl^tm1Bra/Arntl^tm1Weit,Syt10^{tm1.1(icre)Geno}/Syt10^{tm1.1(icre)Geno} Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6
MP:0002151	abnormal neural tube morphology/development	"anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Otof^tm1.1Erei/Otof^tm1.1Erei Genetic Background: involves: 129P2/OlaHsd
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tbx1^m1H/Tbx1^m1H Genetic Background: involves: C3H/HeH * C57BL/6J
MP:0002249	abnormal larynx morphology	"any structural anomaly of the most superior portion of the respiratory tract" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]	Show Allelic Composition: Otof^tm1.1Erei/Otof^tm1.1Erei Genetic Background: involves: 129P2/OlaHsd
MP:0002267	abnormal bronchiole morphology	"any structural anomaly of the conducting airway of the lungs found terminal to the bronchi. These structures contain neither cartilage nor mucous-secreting glands; the epithelium of the bronchioles becomes thinner with each branching. " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]	Show Allelic Composition: Otof^tm1.1Erei/Otof^tm1.1Erei Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fstl1^tm1.2Mvdh/Fstl1^tm1.2Mvdh Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB Allelic Composition: Fstl1^{tm2.1(cre/ERT2)Mvdh}/Fstl1^{tm2.1(cre/ERT2)Mvdh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002270	abnormal alveoli morphology	"any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Arntl^tm1Bra/Arntl^tm1Weit,Syt10^{tm1.1(icre)Geno}/Syt10^{tm1.1(icre)Geno} Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 Allelic Composition: Fstl1^{tm2.1(cre/ERT2)Mvdh}/Fstl1^{tm2.1(cre/ERT2)Mvdh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002275	abnormal type II pneumocyte morphology	"any structural anomaly of the epithelial cells lining the alveoli that produce surfactant " [Pathology , 2nd edition:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Otof^tm1.1Erei/Otof^tm1.1Erei Genetic Background: involves: 129P2/OlaHsd
MP:0002282	abnormal trachea morphology	"structral anomaly of the tube descending from the larynx and branching into the right and left main bronchi" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Otof^tm1.1Erei/Otof^tm1.1Erei Genetic Background: involves: 129P2/OlaHsd
MP:0002285	abnormal tracheal ciliated epithelium morphology	"structural anomaly of the epithelial lining of the trachea which contains numerous ciliated cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]	Show Allelic Composition: Otof^tm1.1Erei/Otof^tm1.1Erei Genetic Background: involves: 129P2/OlaHsd
MP:0002738	hyperresponsive to tactile stimuli	"exaggerated reflex action normally induced by touch or pain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fstl1^tm1.1Nju/Fstl1^tm1.1Nju Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0002833	increased heart weight	"greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]	Show Allelic Composition: Cd68^tm1Xfen/Cd68⁺ Genetic Background: C57BL/6J-Cd68^tm1Xfen
MP:0002910	abnormal excitatory postsynaptic currents	"defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Fstl1^tm1.1Nju/Fstl1^tm1.1Nju Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0002989	small kidney	"reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fstl1^tm1.1Nju/Fstl1^tm1.1Nju Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0003073	abnormal metacarpal bone morphology	"anomaly in the five bones of the forepaws that articulate proximally with the carpal bones and distally with the phlanges" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]	Show Allelic Composition: Fstl1^tm1.2Mvdh/Fstl1^tm1.2Mvdh Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB
MP:0003120	abnormal tracheal cartilage	"any structural anomaly of the cartilaginous structures that support the trachea" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:97123]	Show Allelic Composition: Otof^tm1.1Erei/Otof^tm1.1Erei Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fstl1^tm1.2Mvdh/Fstl1^tm1.2Mvdh Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB Allelic Composition: Fstl1^{tm2.1(cre/ERT2)Mvdh}/Fstl1^{tm2.1(cre/ERT2)Mvdh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003141	cardiac fibrosis	"formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Cd68^tm1Xfen/Cd68⁺ Genetic Background: C57BL/6J-Cd68^tm1Xfen
MP:0003586	ureter dilation	"abnormal distention of the ureter due to accumulation of fluid" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Fstl1^tm1.1Nju/Fstl1^tm1.1Nju Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0003588	ureter stenosis	"abnormal narrowing or constriction of the ureter" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Fstl1^tm1.1Nju/Fstl1^tm1.1Nju Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0003672	abnormal ureter development	"anomalous differentiation of the tube that conducts the urine from the renal pelvis to the bladder" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96485]	Show Allelic Composition: Fstl1^tm1.1Nju/Fstl1^tm1.1Nju Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0003723	abnormal long bone morphology	"malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Fstl1^tm1.2Mvdh/Fstl1^tm1.2Mvdh Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB
MP:0003856	abnormal hindlimb stylopod morphology		Show Allelic Composition: Fstl1^tm1.2Mvdh/Fstl1^tm1.2Mvdh Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB
MP:0003857	abnormal hindlimb zeugopod morphology		Show Allelic Composition: Fstl1^tm1.2Mvdh/Fstl1^tm1.2Mvdh Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB
MP:0003915	increased left ventricle weight	"greater than average weight of the left ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission]	Show Allelic Composition: Cd68^tm1Xfen/Cd68⁺ Genetic Background: C57BL/6J-Cd68^tm1Xfen
MP:0003998	decreased thermal nociceptive threshold	"a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Fstl1^tm1.1Nju/Fstl1^tm1.1Nju Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0004174	abnormal spine curvature	"deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Fstl1^tm1.2Mvdh/Fstl1^tm1.2Mvdh Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB
MP:0004194	abnormal kidney pelvis morphology	"any structural anomaly of the funnel shaped proximal portion of the ureter that is formed by convergence of the major calices" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fstl1^tm1.1Nju/Fstl1^tm1.1Nju Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0004202	pulmonary hyperplasia	"overdevelopment or increased size, usually due an increased number of cells of the respiratory organ in all or part of the organ" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Otof^tm1.1Erei/Otof^tm1.1Erei Genetic Background: involves: 129P2/OlaHsd
MP:0004372	bowed fibula	"increased curvature of the lateral and smaller bone of the lower limb" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Fstl1^tm1.2Mvdh/Fstl1^tm1.2Mvdh Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB
MP:0004485	increased response of heart to induced stress	"increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd68^tm1Xfen/Cd68⁺ Genetic Background: C57BL/6J-Cd68^tm1Xfen
MP:0004551	decreased tracheal cartilage ring number	"less than the 16-20 incomplete rings of hyaline cartilage forming the skeleton of the trachea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Otof^tm1.1Erei/Otof^tm1.1Erei Genetic Background: involves: 129P2/OlaHsd
MP:0004564	enlarged myocardial fiber	"increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd68^tm1Xfen/Cd68⁺ Genetic Background: C57BL/6J-Cd68^tm1Xfen
MP:0004607	abnormal cervical atlas morphology	"any structural anomaly of the first (topmost, C1) cervical vertebra which supports the globe of the head" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fstl1^tm1.2Mvdh/Fstl1^tm1.2Mvdh Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB
MP:0004608	abnormal cervical axis morphology	"any structural anomaly of the second cervical vertebra (C2) which forms the pivot upon which the first cervical (atlas, C1) vertebra rotates" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fstl1^tm1.2Mvdh/Fstl1^tm1.2Mvdh Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB
MP:0004694	absent patella	"absence of the large sesamoid bone that covers the anterior surface of the knee" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Fstl1^tm1.2Mvdh/Fstl1^tm1.2Mvdh Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB
MP:0005140	decreased cardiac muscle contractility	"inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cd68^tm1Xfen/Cd68⁺ Genetic Background: C57BL/6J-Cd68^tm1Xfen
MP:0005293	impaired glucose tolerance	"less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Fgf9^{tm1b(KOMP)Wtsi}/Fgf9^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Fgf9^{tm1b(KOMP)Wtsi}/H
MP:0005402	abnormal action potential	"change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fstl1^tm1.1Nju/Fstl1^tm1.1Nju Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0005440	increased glycogen level	"greater than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Otof^tm1.1Erei/Otof^tm1.1Erei Genetic Background: involves: 129P2/OlaHsd
MP:0005508	abnormal skeleton morphology	"malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Otof^tm1.1Erei/Otof^tm1.1Erei Genetic Background: involves: 129P2/OlaHsd
MP:0005602	decreased angiogenesis	"reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]	Show Allelic Composition: Cd68^tm1Xfen/Cd68⁺ Genetic Background: C57BL/6J-Cd68^tm1Xfen
MP:0006113	abnormal heart septum morphology	"abnormality in the wall between the atria or ventricles of the heart, usually incomplete closure" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Cd68^tm1Xfen/Cd68⁺ Genetic Background: C57BL/6J-Cd68^tm1Xfen
MP:0006382	abnormal lung epithelium morphology	"any structural anomaly of the epithelial layer of the lung" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Otof^tm1.1Erei/Otof^tm1.1Erei Genetic Background: involves: 129P2/OlaHsd
MP:0006432	abnormal costal cartilage morphology	"any structural anomaly of the nonvascular, resilient, flexible connective tissue that connects the end of a true rib to the sternum or the end of a false rib with the costal cartilage above" [ISBN:0-8036-0655-9 "Taber s Cyclopedic Medical Dictionary", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fstl1^tm1.2Mvdh/Fstl1^tm1.2Mvdh Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB Allelic Composition: Fstl1^{tm2.1(cre/ERT2)Mvdh}/Fstl1^{tm2.1(cre/ERT2)Mvdh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008146	asymmetric rib-sternum attachment	"loss of bilateral symmetry in rib attachments to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fstl1^tm1.2Mvdh/Fstl1^tm1.2Mvdh Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB Allelic Composition: Fstl1^tm1.2Mvdh/Fstl1⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB Allelic Composition: Fstl1^{tm2.1(cre/ERT2)Mvdh}/Fstl1^{tm2.1(cre/ERT2)Mvdh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Fstl1^{tm2.1(cre/ERT2)Mvdh}/Fstl1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008532	decreased chemical nociceptive threshold	"a lower than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fstl1^tm1.1Nju/Fstl1^tm1.1Nju Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0008730	fused phalanges	"anomaly of the long bones of the digits resulting in some or all the bones being joined together" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fstl1^tm1.2Mvdh/Fstl1^tm1.2Mvdh Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB Allelic Composition: Fstl1^{tm2.1(cre/ERT2)Mvdh}/Fstl1^{tm2.1(cre/ERT2)Mvdh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0009005	abnormal sesamoid bone of gastrocnemius morphology	"any structural anomaly of the small sesamoid bones situated behind the condyles of the femur" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fstl1^tm1.2Mvdh/Fstl1^tm1.2Mvdh Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB
MP:0010018	lung vascular congestion	"obstruction of the normal flux of blood within the blood vessel network of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd68^tm1Xfen/Cd68⁺ Genetic Background: C57BL/6J-Cd68^tm1Xfen
MP:0010551	abnormal coronary vessel morphology	"any structural anomaly of any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd68^tm1Xfen/Cd68⁺ Genetic Background: C57BL/6J-Cd68^tm1Xfen
MP:0010579	increased heart left ventricle size	"greater than average size of the left ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd68^tm1Xfen/Cd68⁺ Genetic Background: C57BL/6J-Cd68^tm1Xfen
MP:0010810	increased type II pneumocyte number	"greater number of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored" [ISBN:0412046911, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", PMID:8540632]	Show Allelic Composition: Otof^tm1.1Erei/Otof^tm1.1Erei Genetic Background: involves: 129P2/OlaHsd
MP:0010816	decreased type I pneumocyte number	"reduced number of the flattened, branched squamous cells that covers more than 98 percent of the alveolar surface, and have thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange" [PMID:20054144]	Show Allelic Composition: Otof^tm1.1Erei/Otof^tm1.1Erei Genetic Background: involves: 129P2/OlaHsd
MP:0010819	primary atelectasis	"nonexpansion of the lungs after birth, seen in stillborn organisms and in live born animals that do not establish respiration" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Otof^tm1.1Erei/Otof^tm1.1Erei Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Fstl1^tm1.2Mvdh/Fstl1^tm1.2Mvdh Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB Allelic Composition: Fstl1^{tm2.1(cre/ERT2)Mvdh}/Fstl1^{tm2.1(cre/ERT2)Mvdh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0010883	trachea stenosis	"abnormal narrowing or constriction of the trachea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Otof^tm1.1Erei/Otof^tm1.1Erei Genetic Background: involves: 129P2/OlaHsd
MP:0010890	decreased alveolar lamellar body number	"reduced number of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Otof^tm1.1Erei/Otof^tm1.1Erei Genetic Background: involves: 129P2/OlaHsd
MP:0010902	abnormal pulmonary alveolar sac morphology	"any structural anomaly of the small terminal dilation of the alveolar ducts around which the alveoli form pocket-like clusters" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Otof^tm1.1Erei/Otof^tm1.1Erei Genetic Background: involves: 129P2/OlaHsd
MP:0010975	abnormal lung lobe morphology	"any structural anomaly of any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung, where each lobe receives air from its own secondary bronchus and is separated from it neighbors by one or more fissures (walls of connective tissue)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fstl1^tm1.2Mvdh/Fstl1^tm1.2Mvdh Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB Allelic Composition: Fstl1^{tm2.1(cre/ERT2)Mvdh}/Fstl1^{tm2.1(cre/ERT2)Mvdh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0010993	decreased surfactant secretion	"decreased production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Otof^tm1.1Erei/Otof^tm1.1Erei Genetic Background: involves: 129P2/OlaHsd
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Otof^tm1.1Erei/Otof^tm1.1Erei Genetic Background: involves: 129P2/OlaHsd
MP:0011089	complete perinatal lethality	"death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Fstl1^tm1.2Mvdh/Fstl1^tm1.2Mvdh Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB Allelic Composition: Fstl1^{tm2.1(cre/ERT2)Mvdh}/Fstl1^{tm2.1(cre/ERT2)Mvdh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011304	kidney papillary atrophy	"acquired diminution of the size of the apex (tip) of a renal pyramid associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]	Show Allelic Composition: Fstl1^tm1.1Nju/Fstl1^tm1.1Nju Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0011484	abnormal ureter urothelium morphology	"any structural anomaly of the epithelial lining of the luminal space of the ureter" [MGI:csmith]	Show Allelic Composition: Fstl1^tm1.1Nju/Fstl1^tm1.1Nju Genetic Background: involves: 129 * C57BL/6 * FVB/N
MP:0011505	camptomelia	"a skeletal dysplasia characterized by the bending of the long bones of the extremities" [ISBN:0-683-40008-8]	Show Allelic Composition: Fstl1^{tm2.1(cre/ERT2)Mvdh}/Fstl1^{tm2.1(cre/ERT2)Mvdh} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0020040	decreased bone ossification	"decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]	Show Allelic Composition: Fstl1^tm1.2Mvdh/Fstl1^tm1.2Mvdh Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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