ENSMUSG00000022881


Mus musculus

Features
Gene ID: ENSMUSG00000022881
  
Biological name :Rfc4
  
Synonyms : Q99J62 / replication factor C (activator 1) 4 / Rfc4
  
Possible biological names infered from orthology : P35249 / replication factor C subunit 4
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: B1
Gene start: 23113943
Gene end: 23127737
  
Corresponding Affymetrix probe sets: 10438690 (MoGene1.0st)   1424321_at (Mouse Genome 430 2.0 Array)   1438161_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000110994
Ensembl peptide - ENSMUSP00000115479
Ensembl peptide - ENSMUSP00000110995
Ensembl peptide - ENSMUSP00000023598
NCBI entrez gene - 106344     See in Manteia.
MGI - MGI:2146571
RefSeq - NM_145480
RefSeq Peptide - NP_663455
swissprot - D3Z7I8
swissprot - D6RGM1
swissprot - Q3UI84
swissprot - Q99J62
Ensembl - ENSMUSG00000022881
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rfc4ENSDARG00000042458Danio rerio
 RFC4ENSGALG00000008703Gallus gallus
 RFC4ENSG00000163918Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003593  AAA+ ATPase domain
 IPR003959  ATPase, AAA-type, core
 IPR008921  DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal
 IPR013748  Replication factor C, C-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006261 DNA-dependent DNA replication IBA
 biological_processGO:0006281 DNA repair IBA
 biological_processGO:1900264 positive regulation of DNA-directed DNA polymerase activity IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005663 DNA replication factor C complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031390 Ctf18 RFC-like complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003689 DNA clamp loader activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0043142 single-stranded DNA-dependent ATPase activity IEA


Pathways (from Reactome)
Pathway description
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Polymerase switching on the C-strand of the telomere
Activation of ATR in response to replication stress
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Processing of DNA double-strand break ends
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Regulation of TP53 Activity through Phosphorylation
Polymerase switching
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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