ENSMUSG00000022951


Mus musculus

Features
Gene ID: ENSMUSG00000022951
  
Biological name :Rcan1
  
Synonyms : Q9JHG6 / Rcan1 / regulator of calcineurin 1
  
Possible biological names infered from orthology : P53805
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: C4
Gene start: 92391953
Gene end: 92466146
  
Corresponding Affymetrix probe sets: 10440993 (MoGene1.0st)   1416600_a_at (Mouse Genome 430 2.0 Array)   1416601_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023672
Ensembl peptide - ENSMUSP00000060394
NCBI entrez gene - 54720     See in Manteia.
MGI - MGI:1890564
RefSeq - NM_019466
RefSeq - NM_001081549
RefSeq Peptide - NP_001075018
RefSeq Peptide - NP_062339
swissprot - Q542V6
swissprot - Q7TNY3
swissprot - Q9JHG6
Ensembl - ENSMUSG00000022951
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rcan1aENSDARG00000003109Danio rerio
 RCAN1ENSGALG00000016014Gallus gallus
 RCAN1ENSG00000159200Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rcan3 / Q9JKK0 / Calcipressin-3 / Q9UKA8* / RCAN family member 3*ENSMUSG0000005971349
Rcan2 / Q9JHG2 / regulator of calcineurin 2 / Q14206*ENSMUSG0000003960149


Protein motifs (from Interpro)
Interpro ID Name
 IPR006931  Calcipressin
 IPR031271  Calcipressin-1
 IPR034906  Calcipressin-1, RNA recognition motif
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002931 response to ischemia IMP
 biological_processGO:0006979 response to oxidative stress IGI
 biological_processGO:0007614 short-term memory IGI
 biological_processGO:0019722 calcium-mediated signaling IEA
 biological_processGO:0031987 locomotion involved in locomotory behavior IGI
 biological_processGO:0033173 calcineurin-NFAT signaling cascade IMP
 biological_processGO:0043666 regulation of phosphoprotein phosphatase activity IDA
 biological_processGO:0048741 skeletal muscle fiber development IDA
 biological_processGO:0070884 regulation of calcineurin-NFAT signaling cascade IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity IBA
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Matktm1Suda/Matktm1Suda
Genetic Background: involves: C57BL/6 * CBA

 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol
Genetic Background: involves: 129 * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol,Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001458 abnormal object recognition memory "defects in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol
Genetic Background: involves: 129 * C57BL/6

 MP:0001739 abnormal adrenal secretion "altered ability of the surparenal gland to secrete hormones " [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pdx1tm1Macd/Pdx1+,Tg(tetO-Myt1)2Ggu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol,Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Tg(Myh6-Ppp3ca)37Eno/0
Genetic Background: involves: 129 * C57BL/6 * FVB

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Matktm1Suda/Matktm1Suda
Genetic Background: involves: C57BL/6 * CBA

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol,Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: Rad52tm1Aps/Rad52tm1Aps,Rad54ltm1Jhjh/Rad54ltm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pdx1tm1Macd/Pdx1+,Tg(tetO-Myt1)2Ggu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004486 decreased response of heart to induced stress "decrease in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Matktm1Suda/Matktm1Suda
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol,Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol,Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol,Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Rcan1tm1Fmc/Rcan1tm1Fmc
Genetic Background: involves: 129S4/SvJae

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol
Genetic Background: involves: 129 * C57BL/6

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rcan1tm1Fmc/Rcan1tm1Fmc
Genetic Background: involves: 129S4/SvJae

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Rcan1tm1Jmol/Rcan1tm1Jmol,Rcan2tm1Jmol/Rcan2tm1Jmol,Ppp3cbtm1Jmk/Ppp3cbtm1Jmk
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rcan1tm1Fmc/Rcan1tm1Fmc
Genetic Background: involves: 129S4/SvJae

 MP:0006412 abnormal T cell apoptosis "change in the timing or the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rcan1tm1Fmc/Rcan1tm1Fmc
Genetic Background: involves: 129S4/SvJae

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rcan1tm1Fmc/Rcan1tm1Fmc
Genetic Background: involves: 129S4/SvJae

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Rcan1tm1Fmc/Rcan1tm1Fmc
Genetic Background: involves: 129S4/SvJae

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rcan1tm1Fmc/Rcan1tm1Fmc
Genetic Background: involves: 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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