ENSMUSG00000023030


Mus musculus

Features
Gene ID: ENSMUSG00000023030
  
Biological name :Slc11a2
  
Synonyms : P49282 / Slc11a2 / solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
  
Possible biological names infered from orthology : P49281 / solute carrier family 11 member 2
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: F1
Gene start: 100387898
Gene end: 100425072
  
Corresponding Affymetrix probe sets: 10432573 (MoGene1.0st)   1417584_at (Mouse Genome 430 2.0 Array)   1426441_at (Mouse Genome 430 2.0 Array)   1441709_at (Mouse Genome 430 2.0 Array)   1447333_at (Mouse Genome 430 2.0 Array)   1452078_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115283
Ensembl peptide - ENSMUSP00000115019
Ensembl peptide - ENSMUSP00000115357
Ensembl peptide - ENSMUSP00000119056
Ensembl peptide - ENSMUSP00000116463
Ensembl peptide - ENSMUSP00000023774
Ensembl peptide - ENSMUSP00000114702
NCBI entrez gene - 18174     See in Manteia.
MGI - MGI:1345279
RefSeq - XM_017316495
RefSeq - NM_001146161
RefSeq - NM_008732
RefSeq - XM_006520577
RefSeq - XM_006520578
RefSeq - XM_006520579
RefSeq - XM_006520580
RefSeq - XM_011245487
RefSeq Peptide - NP_032758
RefSeq Peptide - NP_001139633
swissprot - D3Z314
swissprot - F6ZM31
swissprot - D3Z0R6
swissprot - P49282
swissprot - D3YXP3
swissprot - D6RGP0
Ensembl - ENSMUSG00000023030
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc11a2ENSDARG00000024295Danio rerio
 P49281ENSG00000110911Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P41251 / Slc11a1 / solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 / P49279* / solute carrier family 11 member 1*ENSMUSG0000002617760


Protein motifs (from Interpro)
Interpro ID Name
 IPR001046  NRAMP family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006778 porphyrin-containing compound metabolic process IMP
 biological_processGO:0006779 porphyrin-containing compound biosynthetic process IMP
 biological_processGO:0006783 heme biosynthetic process IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006824 cobalt ion transport ISO
 biological_processGO:0006825 copper ion transport ISO
 biological_processGO:0006826 iron ion transport IMP
 biological_processGO:0006828 manganese ion transport ISO
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
 biological_processGO:0007611 learning or memory IMP
 biological_processGO:0010039 response to iron ion IEA
 biological_processGO:0015675 nickel cation transport ISO
 biological_processGO:0015676 vanadium ion transport ISO
 biological_processGO:0015684 ferrous iron transport ISO
 biological_processGO:0015692 lead ion transport ISO
 biological_processGO:0030001 metal ion transport IEA
 biological_processGO:0034599 cellular response to oxidative stress ISO
 biological_processGO:0035434 copper ion transmembrane transport IEA
 biological_processGO:0035444 nickel cation transmembrane transport IEA
 biological_processGO:0048813 dendrite morphogenesis IMP
 biological_processGO:0048821 erythrocyte development IMP
 biological_processGO:0055072 iron ion homeostasis IEA
 biological_processGO:0060586 multicellular organismal iron ion homeostasis ISO
 biological_processGO:0070574 cadmium ion transmembrane transport ISS
 biological_processGO:0070627 ferrous iron import ISO
 biological_processGO:0071421 manganese ion transmembrane transport IEA
 biological_processGO:1902600 proton transmembrane transport IEA
 biological_processGO:1903874 ferrous iron transmembrane transport IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005764 lysosome ISO
 cellular_componentGO:0005765 lysosomal membrane ISO
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome ISO
 cellular_componentGO:0005770 late endosome ISO
 cellular_componentGO:0005773 vacuole ISO
 cellular_componentGO:0005802 trans-Golgi network ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane ISO
 cellular_componentGO:0005903 brush border IDA
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0012505 endomembrane system IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane ISO
 cellular_componentGO:0030904 retromer complex ISO
 cellular_componentGO:0031410 cytoplasmic vesicle ISO
 cellular_componentGO:0031526 brush border membrane IGI
 cellular_componentGO:0031902 late endosome membrane ISO
 cellular_componentGO:0045177 apical part of cell ISO
 cellular_componentGO:0045178 basal part of cell ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 cellular_componentGO:0055037 recycling endosome ISO
 cellular_componentGO:0070826 paraferritin complex ISO
 cellular_componentGO:1903561 extracellular vesicle ISO
 molecular_functionGO:0005375 copper ion transmembrane transporter activity ISO
 molecular_functionGO:0005381 iron ion transmembrane transporter activity IDA
 molecular_functionGO:0005384 manganese ion transmembrane transporter activity ISO
 molecular_functionGO:0015078 proton transmembrane transporter activity IDA
 molecular_functionGO:0015086 cadmium ion transmembrane transporter activity ISO
 molecular_functionGO:0015087 cobalt ion transmembrane transporter activity ISO
 molecular_functionGO:0015093 ferrous iron transmembrane transporter activity ISO
 molecular_functionGO:0015094 lead ion transmembrane transporter activity ISO
 molecular_functionGO:0015099 nickel cation transmembrane transporter activity ISO
 molecular_functionGO:0015100 vanadium ion transmembrane transporter activity ISO
 molecular_functionGO:0015295 solute:proton symporter activity ISO
 molecular_functionGO:0022890 inorganic cation transmembrane transporter activity ISO
 molecular_functionGO:0046870 cadmium ion binding ISO
 molecular_functionGO:0046873 metal ion transmembrane transporter activity IEA
 molecular_functionGO:0046915 transition metal ion transmembrane transporter activity ISO


Pathways (from Reactome)
Pathway description
Metal ion SLC transporters
Iron uptake and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ap3b1pe-7J/Ap3b1pe-7J
Genetic Background: involves: DBA/1LacJ

Allelic Composition: Hfetm2Nca/Hfetm2Nca,Slc11a2tm1Nca/Slc11a2tm1Nca
Genetic Background: involves: 129S6/SvEvBrd * 129S6.129S4-Slc11a2tm1Nca

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: MK/ReJ

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: SEC.Cg-Slc11a2mk

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc11a2tm2Nca/Slc11a2tm2Nca,Tg(Vil-cre)20Syr/?
Genetic Background: involves: 129S6.129S4-Slc11a2tm2Nca * C57BL/6 * DBA/2

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Hfetm2Nca/Hfetm2Nca,Slc11a2tm1Nca/Slc11a2tm1Nca
Genetic Background: involves: 129S6/SvEvBrd * 129S6.129S4-Slc11a2tm1Nca

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Hfetm2Nca/Hfetm2Nca,Slc11a2tm1Nca/Slc11a2tm1Nca
Genetic Background: involves: 129S6/SvEvBrd * 129S6.129S4-Slc11a2tm1Nca

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc11a2tm2Nca/Slc11a2tm2Nca,Tg(Vil-cre)20Syr/?
Genetic Background: involves: 129S6.129S4-Slc11a2tm2Nca * C57BL/6 * DBA/2

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
Show

Allelic Composition: Slc11a2tm2Nca/Slc11a2tm2Nca,Tg(Vil-cre)20Syr/?
Genetic Background: involves: 129S6.129S4-Slc11a2tm2Nca * C57BL/6 * DBA/2

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: SEC.Cg-Slc11a2mk

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Slc11a2tm2Nca/Slc11a2tm2Nca,Tg(Vil-cre)20Syr/?
Genetic Background: involves: 129S6.129S4-Slc11a2tm2Nca * C57BL/6 * DBA/2

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: SEC.Cg-Slc11a2mk

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Hfetm2Nca/Hfetm2Nca,Slc11a2tm1Nca/Slc11a2tm1Nca
Genetic Background: involves: 129S6/SvEvBrd * 129S6.129S4-Slc11a2tm1Nca

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ap3b1pe-7J/Ap3b1pe-7J
Genetic Background: involves: DBA/1LacJ

Allelic Composition: Hfetm2Nca/Hfetm2Nca,Slc11a2tm1Nca/Slc11a2tm1Nca
Genetic Background: involves: 129S6/SvEvBrd * 129S6.129S4-Slc11a2tm1Nca

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Slc11a2tm2Nca/Slc11a2tm2Nca,Tg(Vil-cre)20Syr/?
Genetic Background: involves: 129S6.129S4-Slc11a2tm2Nca * C57BL/6 * DBA/2

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: SEC.Cg-Slc11a2mk

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Hfetm2Nca/Hfetm2Nca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: SEC.Cg-Slc11a2mk

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ap3b1pe-7J/Ap3b1pe-7J
Genetic Background: involves: DBA/1LacJ

Allelic Composition: Slc11a2tm2Nca/Slc11a2tm2Nca,Tg(Vil-cre)20Syr/?
Genetic Background: involves: 129S6.129S4-Slc11a2tm2Nca * C57BL/6 * DBA/2

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ap3b1pe-7J/Ap3b1pe-7J
Genetic Background: involves: DBA/1LacJ

 MP:0002593 high mean erythrocyte count "greater than average numbers of red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc11a2tm2Nca/Slc11a2tm2Nca,Tg(Vil-cre)20Syr/?
Genetic Background: involves: 129S6.129S4-Slc11a2tm2Nca * C57BL/6 * DBA/2

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: SEC.Cg-Slc11a2mk

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc11a2tm2Nca/Slc11a2tm2Nca,Tg(Vil-cre)20Syr/?
Genetic Background: involves: 129S6.129S4-Slc11a2tm2Nca * C57BL/6 * DBA/2

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: SEC.Cg-Slc11a2mk

 MP:0002642 anisocytosis "blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ap3b1pe-7J/Ap3b1pe-7J
Genetic Background: involves: DBA/1LacJ

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: MK/ReJ

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: SEC.Cg-Slc11a2mk

 MP:0002643 poikilocytosis "blood cells of variable shape on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ap3b1pe-7J/Ap3b1pe-7J
Genetic Background: involves: DBA/1LacJ

 MP:0002810 microcytic anemia "anemia in which the circulating erythrocyte corpuscular volume is smaller than normal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ap3b1pe-7J/Ap3b1pe-7J
Genetic Background: involves: DBA/1LacJ

 MP:0002813 microcytosis "the presence of unusually small erythrocytes in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: MK/ReJ

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: SEC.Cg-Slc11a2mk

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ap3b1pe-7J/Ap3b1pe-7J
Genetic Background: involves: DBA/1LacJ

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: MK/ReJ

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: SEC.Cg-Slc11a2mk

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ap3b1pe-7J/Ap3b1pe-7J
Genetic Background: involves: DBA/1LacJ

 MP:0003657 abnormal erythrocyte lysis "increase or decrease in the ability of RBCs to withstand changes in osmolarity" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: SEC.Cg-Slc11a2mk

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ap3b1pe-7J/Ap3b1pe-7J
Genetic Background: involves: DBA/1LacJ

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: MK/ReJ

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: SEC.Cg-Slc11a2mk

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: MK/ReJ

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: SEC.Cg-Slc11a2mk

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: MK/ReJ

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: SEC.Cg-Slc11a2mk

 MP:0005637 abnormal iron homeostasis "anomaly in the state of equilibrium in the body with respect to this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:64456]
Show

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: MK/ReJ

 MP:0005642 decreased mean corpuscular hemoglobin concentration "less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
Show

Allelic Composition: Ap3b1pe-7J/Ap3b1pe-7J
Genetic Background: involves: DBA/1LacJ

 MP:0008388 hypochromic microcytic anemia "hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, where the erythrocyte corpuscular volume is smaller than normal" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: MK/ReJ

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: SEC.Cg-Slc11a2mk

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc11a2tm2Nca/Slc11a2tm2Nca,Tg(Vil-cre)20Syr/?
Genetic Background: involves: 129S6.129S4-Slc11a2tm2Nca * C57BL/6 * DBA/2

 MP:0008743 decreased liver iron level "reduction in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Hfetm2Nca/Hfetm2Nca
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Slc11a2tm1Nca/Slc11a2+
Genetic Background: involves: 129S6/SvEvBrd * 129S6.129S4-Slc11a2tm1Nca

Allelic Composition: Slc11a2tm2Nca/Slc11a2tm2Nca,Tg(Vil-cre)20Syr/?
Genetic Background: involves: 129S6.129S4-Slc11a2tm2Nca * C57BL/6 * DBA/2

 MP:0008807 increased liver iron level "increase in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hfetm2Nca/Hfetm2Nca,Slc11a2tm1Nca/Slc11a2tm1Nca
Genetic Background: involves: 129S6/SvEvBrd * 129S6.129S4-Slc11a2tm1Nca

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: 129S6.MK-Slc11a2mk

 MP:0008808 decreased spleen iron level "reduction in the amount of iron present in the spleen tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc11a2tm2Nca/Slc11a2tm2Nca,Tg(Vil-cre)20Syr/?
Genetic Background: involves: 129S6.129S4-Slc11a2tm2Nca * C57BL/6 * DBA/2

 MP:0008956 decreased cellular hemoglobin content "decrease in the mean of the red blood cell hemoglobin concentration (RBC CH) histogram, which represents the distribution of red blood cells by the amount of hemoglobin present in each individual cell independent of cell volume" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: MK/ReJ

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: SEC.Cg-Slc11a2mk

 MP:0010035 increased erythrocyte clearance "increased elimination of aging erythrocytes from the body by autoregulatory mechanisms, often expressed as half-life" [GO:0034102, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: MK/ReJ

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: SEC.Cg-Slc11a2mk

 MP:0010163 hemolysis "destruction of erythrocytes such that hemoglobin is released from the cells; may occur by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: MK/ReJ

Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: SEC.Cg-Slc11a2mk

 MP:0010376 decreased kidney iron level "reduction in the amount of iron present in the renal tissue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc11a2tm2Nca/Slc11a2tm2Nca,Tg(Vil-cre)20Syr/?
Genetic Background: involves: 129S6.129S4-Slc11a2tm2Nca * C57BL/6 * DBA/2

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ap3b1pe-7J/Ap3b1pe-7J
Genetic Background: involves: DBA/1LacJ

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Slc11a2mk/Slc11a2mk
Genetic Background: MK/ReJ

 MP:0011188 increased erythrocyte protoporphyrin level "an accumulation of the intermediates of heme biosynthesis in red blood cells" [MGI:csmith]
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Allelic Composition: Ank1nb/Ank1+
Genetic Background: involves: C57BL/6J * WB/Re

 MP:0020366 decreased brain iron level "reduction in the amount of iron present in the brain tissue" [MGI:Anna]
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Allelic Composition: Slc11a2tm2Nca/Slc11a2tm2Nca,Tg(Vil-cre)20Syr/?
Genetic Background: involves: 129S6.129S4-Slc11a2tm2Nca * C57BL/6 * DBA/2

 MP:0020368 decreased heart iron level "reduction in the amount of iron present in the heart tissue" [MGI:Anna]
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Allelic Composition: Slc11a2tm2Nca/Slc11a2tm2Nca,Tg(Vil-cre)20Syr/?
Genetic Background: involves: 129S6.129S4-Slc11a2tm2Nca * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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