Manteia - Molecule gene

ENSMUSG00000023068

Mus musculus

Features

Gene ID:	ENSMUSG00000023068

Biological name :	Nus1

Synonyms :	Dehydrodolichyl diphosphate synthase complex subunit Nus1 / Nus1 / Q99LJ8

Possible biological names infered from orthology :	NUS1 dehydrodolichyl diphosphate synthase subunit / Q96E22

Species:	Mus musculus

Chr. number:	10
Strand:	1
Band:	B3
Gene start:	52417547
Gene end:	52440183

Corresponding Affymetrix probe sets:	10363137 (MoGene1.0st) 1419914_s_at (Mouse Genome 430 2.0 Array) 1419915_at (Mouse Genome 430 2.0 Array) 1420646_at (Mouse Genome 430 2.0 Array) 1434304_s_at (Mouse Genome 430 2.0 Array) 1440478_at (Mouse Genome 430 2.0 Array) 1460563_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000023830 NCBI entrez gene - 52014 See in Manteia. MGI - MGI:1196365 RefSeq - NM_030250 RefSeq Peptide - NP_084526 swissprot - Q99LJ8 Ensembl - ENSMUSG00000023068

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
nus1	ENSDARG00000027813	Danio rerio
NUS1	ENSGALG00000014899	Gallus gallus
NUS1	ENSG00000153989	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR001441	Decaprenyl diphosphate synthase-like
IPR036424	Decaprenyl diphosphate synthase-like superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001525	angiogenesis	IEA
biological_process	GO:0006486	protein glycosylation	IEA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0019408	dolichol biosynthetic process	IEA
biological_process	GO:0030154	cell differentiation	IEA
biological_process	GO:0032383	regulation of intracellular cholesterol transport	IEA
biological_process	GO:0035268	protein mannosylation	IMP
biological_process	GO:0038084	vascular endothelial growth factor signaling pathway	IEA
biological_process	GO:0042632	cholesterol homeostasis	IMP
biological_process	GO:0043536	positive regulation of blood vessel endothelial cell migration	IEA
biological_process	GO:0051000	positive regulation of nitric-oxide synthase activity	IEA
biological_process	GO:0055092	sterol homeostasis	IMP
cellular_component	GO:0005783	endoplasmic reticulum	IEA
cellular_component	GO:0005789	endoplasmic reticulum membrane	ISO
cellular_component	GO:0016020	membrane	IMP
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0004659	prenyltransferase activity	IEA
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	IEA

Pathways (from Reactome)

Pathway description

Synthesis of Dolichyl-phosphate

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000180	abnormal circulating cholesterol level	"anomalous concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Nus1^tm1.1Qrm/Nus1^tm1.1Qrm,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129 * C57BL/6 * DBA * SJL
MP:0001552	increased circulating triglyceride level	"higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]	Show Allelic Composition: Nus1^tm1.1Qrm/Nus1^tm1.1Qrm,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129 * C57BL/6 * DBA * SJL
MP:0001554	increased circulating free fatty acid level	"higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]	Show Allelic Composition: Nus1^tm1.1Qrm/Nus1^tm1.1Qrm,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129 * C57BL/6 * DBA * SJL
MP:0002118	abnormal lipid homeostasis	"anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Adipoq^tm1Pesch/Adipoq^tm1Pesch Genetic Background: B6.129S7-Adipoq^tm1Pesch Allelic Composition: Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj},Nus1^tm1.1Qrm/Nus1^tm1.1Qrm Genetic Background: involves: 129 * C57BL/6 * SJL
MP:0002628	fatty liver	"an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj},Nus1^tm1.1Qrm/Nus1^tm1.1Qrm Genetic Background: involves: 129 * C57BL/6 * SJL
MP:0003191	abnormal cellular cholesterol metabolism	"impaired regulation of cellular cholesterol levels" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gnao1^tm2.1Rneu/Gnao1⁺ Genetic Background: B6.129S-Gnao1^tm2.1Rneu
MP:0005621	abnormal cell physiology	"aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Gnao1^tm2.1Rneu/Gnao1⁺ Genetic Background: B6.129S-Gnao1^tm2.1Rneu
MP:0008943	increased sensitivity to induced cell death	"decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gnao1^tm2.1Rneu/Gnao1⁺ Genetic Background: B6.129S-Gnao1^tm2.1Rneu
MP:0009355	increased liver triglyceride level	"higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nus1^tm1.1Qrm/Nus1^tm1.1Qrm,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129 * C57BL/6 * DBA * SJL
MP:0010026	decreased liver cholesterol level	"less than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nus1^tm1.1Qrm/Nus1^tm1.1Qrm,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129 * C57BL/6 * DBA * SJL
MP:0010027	increased liver cholesterol level	"greater than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nr1h3^tm1Djm/Nr1h3^tm1Djm,Nus1^tm1.1Qrm/Nus1^tm1.1Qrm,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129 * C57BL/6 * DBA * SJL
MP:0010359	increased liver free fatty acids level	"elevated liver concentrations of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Nus1^tm1.1Qrm/Nus1^tm1.1Qrm,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129 * C57BL/6 * DBA * SJL Allelic Composition: Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj},Nus1^tm1.1Qrm/Nus1^tm1.1Qrm Genetic Background: involves: 129 * C57BL/6 * SJL
MP:0011092	complete embryonic lethality	"death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]	Show Allelic Composition: Gnao1^tm2.1Rneu/Gnao1⁺ Genetic Background: B6.129S-Gnao1^tm2.1Rneu

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000012117	Dhdds / Q99KU1 / Dehydrodolichyl diphosphate synthase complex subunit Dhdds / Q86SQ9* / dehydrodolichyl diphosphate synthase subunit*	/ complex

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr