ENSMUSG00000023247


Mus musculus

Features
Gene ID: ENSMUSG00000023247
  
Biological name :Guca2a
  
Synonyms : Guanylin / Guca2a / P33680
  
Possible biological names infered from orthology : guanylate cyclase activator 2A / Q02747
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D2.1
Gene start: 119637704
Gene end: 119639471
  
Corresponding Affymetrix probe sets: 10507671 (MoGene1.0st)   1416905_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024015
NCBI entrez gene - 14915     See in Manteia.
MGI - MGI:102738
RefSeq - NM_008190
RefSeq Peptide - NP_032216
swissprot - P33680
Ensembl - ENSMUSG00000023247
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GUCA2AENSGALG00000027269Gallus gallus
 GUCA2AENSG00000197273Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000879  Guanylin
 IPR036382  Guanylin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0031284 positive regulation of guanylate cyclase activity IEA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0030250 guanylate cyclase activator activity IEA


Pathways (from Reactome)
Pathway description
Digestion


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004842 abnormal large intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ntf3tm1(Bdnf)Tes/Ntf3tm1(Bdnf)Tes
Genetic Background: involves: 129S1/Sv

 MP:0008883 abnormal enterocyte proliferation "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntf3tm1(Bdnf)Tes/Ntf3tm1(Bdnf)Tes
Genetic Background: involves: 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000042638 Gucy2c / Q3UWA6 / Heat-stable enterotoxin receptor / P25092* / guanylate cyclase 2C*  / complex / reaction






 

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contact: otassy@igbmc.fr