ENSMUSG00000023942


Mus musculus

Features
Gene ID: ENSMUSG00000023942
  
Biological name :Slc29a1
  
Synonyms : Q9JIM1 / Slc29a1 / solute carrier family 29 (nucleoside transporters), member 1
  
Possible biological names infered from orthology : Q99808 / solute carrier family 29 member 1 (Augustine blood group)
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: B3
Gene start: 45585200
Gene end: 45599606
  
Corresponding Affymetrix probe sets: 10451123 (MoGene1.0st)   1451782_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000128304
Ensembl peptide - ENSMUSP00000133162
Ensembl peptide - ENSMUSP00000131976
Ensembl peptide - ENSMUSP00000131646
Ensembl peptide - ENSMUSP00000131483
Ensembl peptide - ENSMUSP00000131217
Ensembl peptide - ENSMUSP00000131116
Ensembl peptide - ENSMUSP00000128763
Ensembl peptide - ENSMUSP00000131075
Ensembl peptide - ENSMUSP00000129345
Ensembl peptide - ENSMUSP00000129242
Ensembl peptide - ENSMUSP00000129240
Ensembl peptide - ENSMUSP00000128999
Ensembl peptide - ENSMUSP00000063096
Ensembl peptide - ENSMUSP00000063757
Ensembl peptide - ENSMUSP00000094923
Ensembl peptide - ENSMUSP00000126703
Ensembl peptide - ENSMUSP00000126934
Ensembl peptide - ENSMUSP00000127343
Ensembl peptide - ENSMUSP00000127754
NCBI entrez gene - 63959     See in Manteia.
MGI - MGI:1927073
RefSeq - NM_001199114
RefSeq - NM_001199115
RefSeq - NM_001199116
RefSeq - NM_001357771
RefSeq - NM_022880
RefSeq - XM_006524768
RefSeq - XM_006524769
RefSeq - XM_006524770
RefSeq - XM_006524771
RefSeq - XM_006524772
RefSeq - XM_006524773
RefSeq - NM_001199113
RefSeq Peptide - NP_001186043
RefSeq Peptide - NP_001186042
RefSeq Peptide - NP_001186044
RefSeq Peptide - NP_001186045
RefSeq Peptide - NP_001344700
RefSeq Peptide - NP_075018
swissprot - E9PXQ6
swissprot - E9Q0Q5
swissprot - E9PXM6
swissprot - E9PWY7
swissprot - E9PWD6
swissprot - E9PVH9
swissprot - Q3TCZ2
swissprot - Q9JIM1
swissprot - E9PZV0
swissprot - E9Q7R8
swissprot - E9Q5E9
swissprot - E9Q503
swissprot - E9Q3D1
swissprot - E9Q221
Ensembl - ENSMUSG00000023942
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc29a1aENSDARG00000101289Danio rerio
 slc29a1bENSDARG00000054447Danio rerio
 SLC29A1ENSGALG00000010182Gallus gallus
 Q99808ENSG00000112759Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q61672 / Slc29a2 / Equilibrative nucleoside transporter 2 / Q14542* / solute carrier family 29 member 2*ENSMUSG0000002489148
Q99P65 / Slc29a3 / Equilibrative nucleoside transporter 3 / Q9BZD2* / solute carrier family 29 member 3*ENSMUSG0000002010030
Q8R139 / Slc29a4 / Equilibrative nucleoside transporter 4 / Q7RTT9* / solute carrier family 29 member 4*ENSMUSG0000005082224


Protein motifs (from Interpro)
Interpro ID Name
 IPR002259  Equilibrative nucleoside transporter
 IPR030195  Equilibrative nucleoside transporter 1
 IPR034764  Nucleoside transporter ENT1/ENT2
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007595 lactation IEA
 biological_processGO:0015858 nucleoside transport ISO
 biological_processGO:0015862 uridine transport IEA
 biological_processGO:0030431 sleep IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:1901642 nucleoside transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane ISS
 cellular_componentGO:0016324 apical plasma membrane ISS
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0005337 nucleoside transmembrane transporter activity IDA


Pathways (from Reactome)
Pathway description
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Cd8atm1Mak/Cd8atm1Mak
Genetic Background: SJL.129S2(B6)-Cd8atm1Mak/Rdgz

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0001539 decreased number of caudal vertebrae "reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0001987 alcohol preference 
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Allelic Composition: Cd8atm1Mak/Cd8atm1Mak
Genetic Background: SJL.129S2(B6)-Cd8atm1Mak/Rdgz

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Cd8atm1Mak/Cd8atm1Mak
Genetic Background: SJL.129S2(B6)-Cd8atm1Mak/Rdgz

 MP:0003047 abnormal thoracic vertebrae morphology "malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0003048 abnormal cervical vertebrae morphology "malformation of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0003545 increased alcohol consumption "greater than normal consumption of alcohol" [RGD:Rat Genome Database submission]
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Allelic Composition: Cd8atm1Mak/Cd8atm1Mak
Genetic Background: SJL.129S2(B6)-Cd8atm1Mak/Rdgz

 MP:0003656 abnormal erythrocyte physiology "functional anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc29a1tm2Msg/Slc29a1tm2Msg,Eportm1(EGFP/cre)Uk/Epor+
Genetic Background: involves: 129X1/SvJ * BALB/cJ

 MP:0003795 abnormal bone structure 
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0004609 vertebral fusion "the union of one or more vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd8atm1Mak/Cd8atm1Mak
Genetic Background: SJL.129S2(B6)-Cd8atm1Mak/Rdgz

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc29a1tm2Msg/Slc29a1tm2Msg,Eportm1(EGFP/cre)Uk/Epor+
Genetic Background: involves: 129X1/SvJ * BALB/cJ

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc29a1tm2Msg/Slc29a1tm2Msg,Eportm1(EGFP/cre)Uk/Epor+
Genetic Background: involves: 129X1/SvJ * BALB/cJ

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc29a1tm2Msg/Slc29a1tm2Msg,Eportm1(EGFP/cre)Uk/Epor+
Genetic Background: involves: 129X1/SvJ * BALB/cJ

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Slc29a1tm2Msg/Slc29a1tm2Msg,Eportm1(EGFP/cre)Uk/Epor+
Genetic Background: involves: 129X1/SvJ * BALB/cJ

 MP:0009755 impaired behavioral response to alcohol "decreased sensitivity to alcohol resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd8atm1Mak/Cd8atm1Mak
Genetic Background: SJL.129S2(B6)-Cd8atm1Mak/Rdgz

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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