ENSMUSG00000023993


Mus musculus

Features
Gene ID: ENSMUSG00000023993
  
Biological name :Treml1
  
Synonyms : Q8K558 / Treml1 / triggering receptor expressed on myeloid cells-like 1
  
Possible biological names infered from orthology : Q86YW5
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: C
Gene start: 48359916
Gene end: 48367176
  
Corresponding Affymetrix probe sets: 10445789 (MoGene1.0st)   1452630_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153104
Ensembl peptide - ENSMUSP00000153300
Ensembl peptide - ENSMUSP00000024792
Ensembl peptide - ENSMUSP00000153029
NCBI entrez gene - 71326     See in Manteia.
MGI - MGI:1918576
RefSeq - NM_001289451
RefSeq - NM_001289457
RefSeq - NM_027763
RefSeq Peptide - NP_001276386
RefSeq Peptide - NP_082039
RefSeq Peptide - NP_001276380
swissprot - Q8K558
swissprot - A6XA73
swissprot - A6XA75
Ensembl - ENSMUSG00000023993
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q86YW5ENSG00000161911Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009968 negative regulation of signal transduction TAS
 biological_processGO:0019722 calcium-mediated signaling ISO
 biological_processGO:0030168 platelet activation IEP
 biological_processGO:0042060 wound healing NAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031091 platelet alpha granule IDA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Tmod2tm1b(KOMP)Wtsi/Tmod2tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmod2tm1b(KOMP)Wtsi/J

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Grid2tm1(cre/PGR)Ksak/Grid2tm1(cre/PGR)Ksak
Genetic Background: C57BL/6-Grid2tm1(cre/PGR)Ksak

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Grid2tm1(cre/PGR)Ksak/Grid2tm1(cre/PGR)Ksak
Genetic Background: C57BL/6-Grid2tm1(cre/PGR)Ksak

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Grid2tm1(cre/PGR)Ksak/Grid2tm1(cre/PGR)Ksak
Genetic Background: C57BL/6-Grid2tm1(cre/PGR)Ksak

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Grid2tm1(cre/PGR)Ksak/Grid2tm1(cre/PGR)Ksak
Genetic Background: C57BL/6-Grid2tm1(cre/PGR)Ksak

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Grid2tm1(cre/PGR)Ksak/Grid2tm1(cre/PGR)Ksak
Genetic Background: C57BL/6-Grid2tm1(cre/PGR)Ksak

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
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Allelic Composition: Grid2tm1(cre/PGR)Ksak/Grid2tm1(cre/PGR)Ksak
Genetic Background: C57BL/6-Grid2tm1(cre/PGR)Ksak

 MP:0011514 skin hemorrhage "bleeding into the skin" [MGI:anna]
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Allelic Composition: Grid2tm1(cre/PGR)Ksak/Grid2tm1(cre/PGR)Ksak
Genetic Background: C57BL/6-Grid2tm1(cre/PGR)Ksak

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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