MP:0000024 | lowered ear position | "outer ears which are situated below the normal location " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: B6.129S7-Twsg1tm1.1Mboc
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MP:0000060 | delayed bone ossification | "late onset of the formation of bone" [J:40203] |
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Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
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MP:0000063 | reduced bone density | "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315] |
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
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MP:0000087 | absent mandible | "missing the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL
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MP:0000137 | abnormal vertebrae morphology | "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
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MP:0000220 | increased monocyte count | "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
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MP:0000322 | increased granulocyte number | "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
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MP:0000428 | abnormal craniofacial morphology | "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: 129S/SvEv-Twsg1tm1.1Mboc
Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: B6.129S7-Twsg1tm1.1Mboc
Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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MP:0000432 | abnormal head morphology | "anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: B6.129S7-Twsg1tm1.1Mboc
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MP:0000452 | abnormal mouth morphology | "anomalous structure or development of the oral cavity" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
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MP:0000454 | abnormal jaw morphology | "malformation of the bony framework of the mouth where the teeth are held" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: 129S/SvEv-Twsg1tm1.1Mboc
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MP:0000458 | abnormal mandible morphology | "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: B6.129S7-Twsg1tm1.1Mboc
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MP:0000474 | abnormal foregut morphology | "malformed cephalic portion of the primitive digestive tube of the embryo" [J:35802] |
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Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
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MP:0000527 | abnormal kidney development | "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
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MP:0000585 | kinked tail | "a sharp bend or zig-zag in the tail" [J:61295] |
Show
Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Twsg1tm1Dgen/Twsg1tm1Dgen Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Twsg1tm1Ecan/Twsg1tm1Ecan Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
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MP:0000592 | short tail | "reduced length of tail compared to control " [J:55583] |
Show
Allelic Composition: Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Twsg1tm1Ecan/Twsg1tm1Ecan Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
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MP:0000704 | abnormal thymus development | "anomaly in the formation and/or differentiation of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
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MP:0000715 | decreased thymocyte number | "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
Show
Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
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MP:0000745 | tremors | "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
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MP:0000755 | hindlimb paralysis | "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
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MP:0000783 | abnormal forebrain morphology | "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857] |
Show
Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL
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MP:0000830 | abnormal diencephalon morphology | "any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL
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MP:0000914 | exencephaly | "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840] |
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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MP:0000934 | abnormal telencephalon development | "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840] |
Show
Allelic Composition: Kdrtm1Jrt/Kdr+,Rasip1tm1.1Oncl/Rasip1tm1.1Oncl Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
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MP:0001258 | decreased body length | "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator] |
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Allelic Composition: Celsr2tm1Dgen/Celsr2+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Tg(ACTB-NOTCH1)1Shn/0,Tg(Nes-cre)1Kln/0,Trp53tm1Tyj/Trp53+ Genetic Background: involves: 129S2/SvPas * C57BL/6J
Allelic Composition: Twsg1tm1Dgen/Twsg1tm1Dgen Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: 129S/SvEv-Twsg1tm1.1Mboc
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MP:0001263 | weight loss | "progressive reduction of body weight below normal average for age" [J:45400] |
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Allelic Composition: Twsg1tm1Dgen/Twsg1tm1Dgen Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
Show
Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Twsg1tm1Ecan/Twsg1tm1Ecan Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: 129S/SvEv-Twsg1tm1.1Mboc
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MP:0001288 | abnormal lens induction | "malformation of or failure to form the transparent, biconvex structure of the eye which is situated behind the iris and in front of the vitreous humor" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL
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MP:0001293 | anophthalmia | "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979] |
Show
Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: B6.129S7-Twsg1tm1.1Mboc
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MP:0001297 | microphthalmia | "reduced average size of the eyes" [J:18048] |
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Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: B6.129S7-Twsg1tm1.1Mboc
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MP:0001325 | abnormal retina morphology | "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL
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MP:0001406 | abnormal gait | "unusual or distinctive way of walking" [J:65038] |
Show
Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
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MP:0001539 | decreased number of caudal vertebrae | "reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
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MP:0001634 | internal hemorrhage | "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170] |
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
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MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
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MP:0002081 | perinatal lethality | "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: B6.129S7-Twsg1tm1.1Mboc
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MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
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MP:0002111 | abnormal tail morphology | "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Tg(ACTB-NOTCH1)1Shn/0,Tg(Nes-cre)1Kln/0,Trp53tm1Tyj/Trp53+ Genetic Background: involves: 129S2/SvPas * C57BL/6J
Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Twsg1tm1Ecan/Twsg1tm1Ecan Genetic Background: involves: 129 * C57BL/6
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MP:0002113 | abnormal skeleton development | "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Twsg1tm1Ecan/Twsg1tm1Ecan Genetic Background: involves: 129 * C57BL/6
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MP:0002115 | abnormal skeleton extremities morphology | "abnormal development of limb, foot or tail bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
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MP:0002144 | abnormal B lymphocyte development | "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
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MP:0002233 | abnormal nose morphology | "any structural anomaly of the organ that is specialized for smell and is part of the respiratory system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL
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MP:0002252 | abnormal oropharynx morphology | "structural anomaly of the portion of the pharynx that lies between the soft palate and the upper edge of the epiglottis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
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MP:0002398 | abnormal bone marrow cell morphology/development | "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
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MP:0002427 | dwarfism | "abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
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MP:0002759 | abnormal caudal vertebrae morphology | "malformed bony segments of the tail, usually 27-30 present" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82849] |
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Allelic Composition: Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
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MP:0002875 | decreased erythrocyte count | "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
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MP:0003047 | abnormal thoracic vertebrae morphology | "malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
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MP:0003048 | abnormal cervical vertebrae morphology | "malformation of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: B6.129S7-Twsg1tm1.1Mboc
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MP:0003055 | abnormal epiphyseal plate morphology | "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
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MP:0003109 | short femur | "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Twsg1tm1Ecan/Twsg1tm1Ecan Genetic Background: involves: 129 * C57BL/6
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MP:0003179 | decreased platelet count | "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052] |
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
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MP:0003409 | decreased width of hypertrophic chondrocyte zone | "decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
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MP:0003419 | delayed endochondral bone ossification | "late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631] |
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
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MP:0003644 | thymus atrophy | "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
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MP:0003662 | abnormal proliferative zone | "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254] |
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
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MP:0003935 | abnormal craniofacial development | "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: B6.129S7-Twsg1tm1.1Mboc
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MP:0004173 | abnormal intervertebral disk morphology | "malformation of the cartilagenous and gelatinous structure found between vertebrae" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
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MP:0004277 | abnormal lateral ganglionic eminence morphology | "any structural anomaly of a distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the striatum; however, neocortex, thalamus, septum and olfactory bulb neurons are also partly derived from the LGE" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL
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MP:0004599 | abnormal vertebral arch morphology | "any structural anomaly of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: 129S/SvEv-Twsg1tm1.1Mboc
Allelic Composition: Chrdtm1Emdr/Chrdtm1Emdr,Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N
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MP:0004601 | abnormal vertebral spinous process | "any structural anomaly of the dorsal projection of the vertebral arch that projects backward and downward from the junction of the laminae, and serves for the attachment of muscles and ligaments" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
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MP:0004605 | abnormal vertebral lamina morphology | "any structural anomaly of two broad plates directed dorsomedially from the pedicles; these fuse at the dorsal midline, and complete the dorsal wall of the vertebral foramen
" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
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MP:0004703 | abnormal vertebral column | "any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmpertm1Emdr/Bmpertm1Emdr,Chrdtm1Emdr/Chrdtm1Emdr Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0004711 | persistence of notochord tissue | "failure of notochord tissue to differentiate into the vertebral primordia during development resulting in the presence of notochord tissue at later stages than it is normally seen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
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MP:0004872 | absent nasal septum | "absence of the structure that separates the two nasal cavities" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL
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MP:0004874 | abnormal timing of postnatal eyelid opening | "anomaly in the average time for the first postnatal eye opening, or failure of eyes to ever open" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
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MP:0005016 | decreased lymphocyte number | "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
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MP:0005092 | decreased double-positive T cell count | "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
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MP:0005150 | cachexia | "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
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MP:0005157 | holoprosencephaly | "presence of a single forebrain hemisphere or lobe; often accompanied by a deficit in median facial development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83058] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
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MP:0005163 | cyclopia | "a congenital defect in which the two orbits are united to form a single cavity containing one eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60303] |
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Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: B6.129S7-Twsg1tm1.1Mboc
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MP:0005226 | abnormal vertebral arch development | "anomalous formation of the posterior projection from the body of a vertebra that encloses the vertebral foramen " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
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MP:0005229 | abnormal intervertebral disk development | "anomalous fromation of the cartilagenous and gelatinous structure found between vertebrae" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
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MP:0005416 | abnormal circulating protein level | "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Twsg1tm1Ecan/Twsg1tm1Ecan Genetic Background: involves: 129 * C57BL/6
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MP:0005508 | abnormal skeleton morphology | "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Twsg1tm1Ecan/Twsg1tm1Ecan Genetic Background: involves: 129 * C57BL/6
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MP:0006050 | pulmonary fibrosis | "formation of fibrous tissue within the lung often resulting from inflammation or injury " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
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MP:0006086 | decreased body mass index | "less than normal average of a measure of weight for height " [ncbi:NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Twsg1tm1Dgen/Twsg1tm1Dgen Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0006341 | small first branchial arch | "reduced size of the first branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Kdrtm1Jrt/Kdr+,Rasip1tm1.1Oncl/Rasip1tm1.1Oncl Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
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MP:0008082 | increased single-positive T cell number | "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
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MP:0008208 | decreased pro-B cell number | "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
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MP:0008209 | decreased pre-B cell number | "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
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MP:0008215 | decreased immature B cell number | "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
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MP:0008273 | abnormal intramembranous bone ossification | "anomaly in the process of the formation of bone in which osteoblasts secrete a collage-proteoglycan matrix that binds calcium salts and becomes calcified; intramembranous ossification is the way flat bones are formed" [GO:0001957] |
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
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MP:0008479 | decreased spleen white pulp amount | "reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
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MP:0009323 | abnormal spleen development | "aberrant formation or incomplete differentiation of the organ that filters blood and stores red corpuscles and platelets" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
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MP:0009339 | decreased splenocyte number | "reduction in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
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MP:0009524 | absent submandibular gland | "absence of either of the large major salivary glands situated beneath the mandible" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: B6.129S7-Twsg1tm1.1Mboc
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MP:0009541 | increased thymocyte apoptosis | "increase in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
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MP:0009576 | oral atresia | "congenital blockage, fusion, or absence of the normal opening of the oral cavity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL
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MP:0009880 | microstomia | "abnormally decreased size of the mouth" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: B6.129S7-Twsg1tm1.1Mboc
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MP:0009901 | abnormal frontonasal prominence morphology | "any structural anomaly of an unpaired facial process in the embryo formed from the tissues surrounding the forebrain vesicle that develops into the forehead and bridge of the nose/snout" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Kdrtm1Jrt/Kdr+,Rasip1tm1.1Oncl/Rasip1tm1.1Oncl Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
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MP:0009905 | absent tongue | "absence of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL
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MP:0010124 | decreased bone mineral content | "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Twsg1tm1Ecan/Twsg1tm1Ecan Genetic Background: involves: 129 * C57BL/6
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MP:0010335 | fused first branchial arch | "the first arch fails to fully divide along the midline" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: B6.129S7-Twsg1tm1.1Mboc
Allelic Composition: Tg(Sox10-cre)1Wdr/0,Twsg1tm1Aptr/Twsg1tm1Aptr Genetic Background: involves: C57BL/6 * CBA
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MP:0010869 | decreased bone trabecula number | "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Twsg1tm1Ecan/Twsg1tm1Ecan Genetic Background: involves: 129 * C57BL/6
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MP:0010876 | decreased bone volume | "reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Twsg1tm1Ecan/Twsg1tm1Ecan Genetic Background: involves: 129 * C57BL/6
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MP:0010879 | decreased trabecular bone volume | "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Twsg1tm1Ecan/Twsg1tm1Ecan Genetic Background: involves: 129 * C57BL/6
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MP:0011084 | partial lethality at weaning | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms at weaning age" [MGI:csmith] |
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Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: 129S/SvEv-Twsg1tm1.1Mboc
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MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: B6.129S7-Twsg1tm1.1Mboc
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MP:0011088 | partial neonatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: 129S/SvEv-Twsg1tm1.1Mboc
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MP:0011090 | partial perinatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: B6.129S7-Twsg1tm1.1Mboc
Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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MP:0011101 | partial prenatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Twsg1tm1Ecan/Twsg1tm1Ecan Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Bmpertm1Emdr/Bmper+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129 * C57BL/6 * SJL
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MP:0013541 | abnormal submandibular gland development | "aberrant formation or incomplete differentiation of either of the paired compound tubuloalveolar (aka tubuloacinar) major salivary glands composed of both serous and mucous secretory cells and situated beneath the mandible; in mice, submandibular gland development initiates as a thickening of the oral epithelium; around E12 an initial (single) epithelial bud on a stalk grows into a condensing neural crest-derived mesenchyme; clefts in the epithelium result in 3-5 epithelial buds at E13.5, and branching morphogenesis occurs with continued proliferation, successive rounds of cleft formation, duct elongation, and duct lumen formation, so that by E14 the gland is highly branched (multi-lobed); functional differentiation, with the appearance of proacinar cells and secretory products begins after E15 and continues to birth; acinar differentiation continues postnatally with final differentiation of the granular convoluted tubules at puberty" [MGI:Anna, PMID:17336109] |
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Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: B6.129S7-Twsg1tm1.1Mboc
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MP:0013790 | single external naris | "presence of only one anterior opening to the nasal cavity as opposed to the normal two; usually associated with midline facial defects arising from cleavage anomalies" [MGI:Anna] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: B6.129S7-Twsg1tm1.1Mboc
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MP:0030268 | agnathia | "congenital, complete or partial, absence of one or both jaws; total absence of the maxilla and/or mandible is extremely rare in mammals; when agnathia occurs, it may be combined with cyclopia or synotia" [https://mdefine.org/a/agnathia-37b.html] |
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Allelic Composition: Twsg1tm1.1Mboc/Twsg1tm1.1Mboc Genetic Background: B6.129S7-Twsg1tm1.1Mboc
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MP:0030279 | thin neurocranium | "decreased thickness of the bones of the skull enclosing the brain" [MGI:anna] |
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Allelic Composition: Bdnftm1(Ntf3)Pern/Bdnftm1(Ntf3)Pern Genetic Background: involves: 129P2/OlaHsd
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