ENSMUSG00000024101


Mus musculus

Features
Gene ID: ENSMUSG00000024101
  
Biological name :Washc1
  
Synonyms : Q8VDD8 / Washc1 / WASH complex subunit 1
  
Possible biological names infered from orthology : A8K0Z3
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: E1.1
Gene start: 66111546
Gene end: 66120503
  
Corresponding Affymetrix probe sets: 10446427 (MoGene1.0st)   1424597_at (Mouse Genome 430 2.0 Array)   1451404_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000072220
Ensembl peptide - ENSMUSP00000112255
NCBI entrez gene - 68767     See in Manteia.
MGI - MGI:1916017
RefSeq - XM_006524860
RefSeq - NM_001037757
RefSeq - NM_026833
RefSeq - XM_006524859
RefSeq Peptide - NP_001032846
RefSeq Peptide - NP_081109
swissprot - Q8VDD8
Ensembl - ENSMUSG00000024101
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wash1ENSDARG00000063457Danio rerio
 WASHC1ENSGALG00000012974Gallus gallus
 A8K0Z3ENSG00000181404Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003124  WH2 domain
 IPR021854  WASH1, WAHD domain
 IPR028290  WASH1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001556 oocyte maturation IMP
 biological_processGO:0002468 dendritic cell antigen processing and presentation IMP
 biological_processGO:0006887 exocytosis ISO
 biological_processGO:0007032 endosome organization IMP
 biological_processGO:0010507 negative regulation of autophagy IMP
 biological_processGO:0016197 endosomal transport IMP
 biological_processGO:0022617 extracellular matrix disassembly ISO
 biological_processGO:0030335 positive regulation of cell migration ISO
 biological_processGO:0030833 regulation of actin filament polymerization IMP
 biological_processGO:0031274 positive regulation of pseudopodium assembly ISO
 biological_processGO:0031396 regulation of protein ubiquitination IDA
 biological_processGO:0034314 Arp2/3 complex-mediated actin nucleation ISO
 biological_processGO:0034383 low-density lipoprotein particle clearance IMP
 biological_processGO:0034394 protein localization to cell surface IMP
 biological_processGO:0040038 polar body extrusion after meiotic divisions IMP
 biological_processGO:0042098 T cell proliferation IMP
 biological_processGO:0042147 retrograde transport, endosome to Golgi ISS
 biological_processGO:0043553 negative regulation of phosphatidylinositol 3-kinase activity IDA
 biological_processGO:0050776 regulation of immune response IMP
 biological_processGO:0090306 spindle assembly involved in meiosis IMP
 biological_processGO:0099638 endosome to plasma membrane protein transport IMP
 biological_processGO:1904109 positive regulation of cholesterol import IMP
 biological_processGO:1990126 retrograde transport, endosome to plasma membrane IMP
 biological_processGO:2000010 positive regulation of protein localization to cell surface IMP
 cellular_componentGO:0000145 exocyst ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome ISO
 cellular_componentGO:0005776 autophagosome IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031083 BLOC-1 complex IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 cellular_componentGO:0055037 recycling endosome IDA
 cellular_componentGO:0055038 recycling endosome membrane IEA
 cellular_componentGO:0071203 WASH complex ISS
 cellular_componentGO:0071437 invadopodium ISO
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0043014 alpha-tubulin binding ISS
 molecular_functionGO:0043015 gamma-tubulin binding IDA
 molecular_functionGO:0050750 low-density lipoprotein particle receptor binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ttntm1.1Hgra/Ttntm1.1Hgra
Genetic Background: B6.Cg-Ttntm1.1Hgra

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ttntm1.1Hgra/Ttntm1.1Hgra
Genetic Background: B6.Cg-Ttntm1.1Hgra

Allelic Composition: Washc1tm1Xya/Washc1tm1Xya
Genetic Background: involves: 129

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-tdTomato*,-EGFP*)Ees/Gt(ROSA)26Sortm1(CAG-tdTomato*,-EGFP*)Ees
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

Allelic Composition: Washc1tm1.1Xya/Washc1tm1.1Xya
Genetic Background: involves: 129 * FVB/N

 MP:0011199 abnormal amniotic cavity morphology "any structural anomaly of the closed space between the embryo and the amnion, containing the amniotic fluid; it is formed by the fusion of the parts of the anterior and posterior amniotic folds" [ISBN:0-12-402035-6]
Show

Allelic Composition: Washc1tm1.1Xya/Washc1tm1.1Xya
Genetic Background: involves: 129 * FVB/N

 MP:0011200 abnormal extraembryonic coelom morphology "any structural anomaly of the fluid-filled spaces formed within the mass of extraembryonic mesoderm that later fuse to become a large extraembryonic cavity" [ISBN:0-12-402035-6, ISBN-10:1405118660]
Show

Allelic Composition: Washc1tm1.1Xya/Washc1tm1.1Xya
Genetic Background: involves: 129 * FVB/N

 MP:0011202 abnormal ectoplacental cavity morphology "any structural anomaly of the closed space within the ectoplacental cone, formed by the fusion of the parts of the amniotic fold that separate it from the amniotic cavity" [ISBN:0-12-402035-6]
Show

Allelic Composition: Washc1tm1.1Xya/Washc1tm1.1Xya
Genetic Background: involves: 129 * FVB/N

 MP:0012556 increased cell death "increased occurrence of the cessation of function at the cellular level" [http://orcid.org/0000-0001-5208-3432]
Show

Allelic Composition: Washc1tm1.1Xya/Washc1tm1.1Xya
Genetic Background: involves: 129 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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