ENSMUSG00000024145


Mus musculus

Features
Gene ID: ENSMUSG00000024145
  
Biological name :Pigf
  
Synonyms : O09101 / Phosphatidylinositol-glycan biosynthesis class F protein / Pigf
  
Possible biological names infered from orthology : phosphatidylinositol glycan anchor biosynthesis class F / Q07326
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: E4
Gene start: 86997256
Gene end: 87025406
  
Corresponding Affymetrix probe sets: 10453429 (MoGene1.0st)   1448896_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024957
NCBI entrez gene - 18701     See in Manteia.
MGI - MGI:99462
RefSeq - NM_008838
RefSeq - XM_006523831
RefSeq Peptide - NP_032864
swissprot - O09101
Ensembl - ENSMUSG00000024145
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pigfENSDARG00000032780Danio rerio
 PIGFENSGALG00000020057Gallus gallus
 PIGFENSG00000151665Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009580  GPI biosynthesis protein Pig-F


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006506 GPI anchor biosynthetic process IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0016780 phosphotransferase activity, for other substituted phosphate groups TAS


Pathways (from Reactome)
Pathway description
Synthesis of glycosylphosphatidylinositol (GPI)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Pfn1tm1a(EUCOMM)Wtsi/Pfn1+
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd Pfn1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pfn1tm1a(EUCOMM)Wtsi/Pfn1+
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd Pfn1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pfn1tm1a(EUCOMM)Wtsi/Pfn1+
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd Pfn1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pfn1tm1a(EUCOMM)Wtsi/Pfn1+
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd Pfn1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Izumo1rtm2a(KOMP)Wtsi/Izumo1rtm2a(KOMP)Wtsi
Genetic Background: C57BL/6N-Izumo1rtm2a(KOMP)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029263 Pigg / phosphatidylinositol glycan anchor biosynthesis class G / Q5H8A4*  / complex






 

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