ENSMUSG00000024170


Mus musculus

Features
Gene ID: ENSMUSG00000024170
  
Biological name :Telo2
  
Synonyms : Q9DC40 / Telo2 / Telomere length regulation
  
Possible biological names infered from orthology : Q9Y4R8 / telomere maintenance 2
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A3.3
Gene start: 25099570
Gene end: 25115967
  
Corresponding Affymetrix probe sets: 10448842 (MoGene1.0st)   1423887_a_at (Mouse Genome 430 2.0 Array)   1423888_at (Mouse Genome 430 2.0 Array)   1456579_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024987
Ensembl peptide - ENSMUSP00000110835
NCBI entrez gene - 71718     See in Manteia.
MGI - MGI:1918968
RefSeq - XM_017317644
RefSeq - NM_001163661
RefSeq - NM_027880
RefSeq - XM_011246618
RefSeq - XM_011246619
RefSeq Peptide - NP_001157133
RefSeq Peptide - NP_082156
swissprot - Q9DC40
Ensembl - ENSMUSG00000024170
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 telo2ENSDARG00000000830Danio rerio
 TELO2ENSGALG00000009297Gallus gallus
 TELO2ENSG00000100726Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011989  Armadillo-like helical
 IPR019337  Telomere length regulation protein, conserved domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0032006 regulation of TOR signaling ISS
 biological_processGO:0050821 protein stabilization IMP
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity ISO
 biological_processGO:1904263 positive regulation of TORC1 signaling ISO
 biological_processGO:1904515 positive regulation of TORC2 signaling ISO
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0005622 intracellular ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016604 nuclear body ISO
 cellular_componentGO:0031931 TORC1 complex ISO
 cellular_componentGO:0031932 TORC2 complex ISO
 cellular_componentGO:0034399 nuclear periphery ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0032947 protein-containing complex scaffold activity IMP
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0051879 Hsp90 protein binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Dh/Dh+,Foxn1nu/Foxn1nu
Genetic Background: involves: N:NIH(S)

Allelic Composition: Telo2tm1Tdl/Telo2tm1.1Tdl,Trp53tm1Tyj/Trp53tm1Tyj,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S2/SvPas * C57BL/6J

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dh/Dh+,Foxn1nu/Foxn1nu
Genetic Background: involves: N:NIH(S)

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
Show

Allelic Composition: Dh/Dh+,Foxn1nu/Foxn1nu
Genetic Background: involves: N:NIH(S)

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Telo2tm1Tdl/Telo2tm1.1Tdl,Trp53tm1Tyj/Trp53tm1Tyj,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S2/SvPas * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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