ENSMUSG00000024245


Mus musculus

Features
Gene ID: ENSMUSG00000024245
  
Biological name :Tmem178
  
Synonyms : Q9CZ16 / Tmem178 / Transmembrane protein 178A
  
Possible biological names infered from orthology : Q8NBL3 / TMEM178A
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: E3
Gene start: 80944632
Gene end: 81001816
  
Corresponding Affymetrix probe sets: 10447120 (MoGene1.0st)   1429175_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025092
NCBI entrez gene - 68027     See in Manteia.
MGI - MGI:1915277
RefSeq - NM_026516
RefSeq Peptide - NP_080792
swissprot - Q9CZ16
Ensembl - ENSMUSG00000024245
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tmem178ENSDARG00000020758Danio rerio
 TMEM178AENSGALG00000028327Gallus gallus
 Q8NBL3ENSG00000152154Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tmem178b / transmembrane protein 178B / H3BS89*ENSMUSG0000005771620


Protein motifs (from Interpro)
Interpro ID Name
 IPR004031  PMP-22/EMP/MP20/Claudin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0045671 negative regulation of osteoclast differentiation IMP
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration IMP
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Ednrbtm1.1Nrd/Ednrb+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: Ednrbtm1.1Nrd/Ednrb+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003724 susceptibility to induced arthritis "more likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Ednrbtm1.1Nrd/Ednrb+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004016 decreased bone mass "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ednrbtm1.1Nrd/Ednrb+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ednrbtm1.1Nrd/Ednrb+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004992 increased bone resorption "greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ednrbtm1.1Nrd/Ednrb+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ednrbtm1.1Nrd/Ednrb+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ednrbtm1.1Nrd/Ednrb+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010873 decreased trabecular bone mass "reduced total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ednrbtm1.1Nrd/Ednrb+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010879 decreased trabecular bone volume "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ednrbtm1.1Nrd/Ednrb+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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