ENSMUSG00000024286


Mus musculus

Features
Gene ID: ENSMUSG00000024286
  
Biological name :Ccny
  
Synonyms : Ccny / Cyclin-Y / Q8BGU5
  
Possible biological names infered from orthology : Q8ND76
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: A1
Gene start: 9314044
Gene end: 9450150
  
Corresponding Affymetrix probe sets: 10457385 (MoGene1.0st)   1428413_at (Mouse Genome 430 2.0 Array)   1428414_at (Mouse Genome 430 2.0 Array)   1428971_at (Mouse Genome 430 2.0 Array)   1432352_at (Mouse Genome 430 2.0 Array)   1452984_at (Mouse Genome 430 2.0 Array)   1454201_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000050001
NCBI entrez gene - 67974     See in Manteia.
MGI - MGI:1915224
RefSeq - XM_017317975
RefSeq - NM_026484
RefSeq - XM_017317974
RefSeq Peptide - NP_080760
swissprot - Q8BGU5
Ensembl - ENSMUSG00000024286
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccnyENSDARG00000063677Danio rerio
 CCNYENSGALG00000007076Gallus gallus
 CCNYENSG00000108100Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ccnyl1 / cyclin Y-like 1ENSMUSG0000007087165


Protein motifs (from Interpro)
Interpro ID Name
 IPR006671  Cyclin, N-terminal
 IPR012399  Cyclin Y
 IPR013763  Cyclin-like
 IPR036915  Cyclin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IEA
 biological_processGO:0000086 G2/M transition of mitotic cell cycle IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0060828 regulation of canonical Wnt signaling pathway IEA
 cellular_componentGO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0005334 abnormal fat pad "malformed or aberrant size of the encapsulated adipose tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0008963 increased carbon dioxide production "increase in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0009293 decreased inguinal fat pad weight 
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0009303 decreased renal fat pad weight 
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0009305 decreased retroperitoneal fat pad weight 
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Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0011168 abnormal fat cell differentiation "abnormal or arrest of differentiation of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449, MGI:csmith]
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0011698 abnormal brown adipose tissue physiology "any functional anomaly in the thermogenic form of adipose tissue that is composed of brown adipocytes" [MGI:smb]
Show

Allelic Composition: Vgftm1Vlcg/Vgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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