ENSMUSG00000024287


Mus musculus

Features
Gene ID: ENSMUSG00000024287
  
Biological name :Thoc1
  
Synonyms : Q8R3N6 / Thoc1 / THO complex subunit 1
  
Possible biological names infered from orthology : Q96FV9 / THO complex 1
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: A1
Gene start: 9958180
Gene end: 9995484
  
Corresponding Affymetrix probe sets: 10453766 (MoGene1.0st)   1420042_at (Mouse Genome 430 2.0 Array)   1420043_s_at (Mouse Genome 430 2.0 Array)   1424641_a_at (Mouse Genome 430 2.0 Array)   1424642_at (Mouse Genome 430 2.0 Array)   1431044_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025137
NCBI entrez gene - 225160     See in Manteia.
MGI - MGI:1919668
RefSeq - NM_153552
RefSeq Peptide - NP_705780
swissprot - Q8R3N6
Ensembl - ENSMUSG00000024287
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 thoc1ENSDARG00000088246Danio rerio
 THOC1ENSGALG00000014915Gallus gallus
 THOC1ENSG00000079134Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR011029  Death-like domain superfamily
 IPR021861  THO complex, subunit THOC1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000018 regulation of DNA recombination IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006406 mRNA export from nucleus IEA
 biological_processGO:0006915 apoptotic process RCA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0031297 replication fork processing IEA
 biological_processGO:0032784 regulation of DNA-templated transcription, elongation IEA
 biological_processGO:0032786 positive regulation of DNA-templated transcription, elongation IEA
 biological_processGO:0042981 regulation of apoptotic process RCA
 biological_processGO:0046784 viral mRNA export from host cell nucleus IEA
 biological_processGO:0048297 negative regulation of isotype switching to IgA isotypes IMP
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:2000002 negative regulation of DNA damage checkpoint IEA
 cellular_componentGO:0000346 transcription export complex IEA
 cellular_componentGO:0000347 THO complex IEA
 cellular_componentGO:0000445 THO complex part of transcription export complex IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0016607 nuclear speck ISO
 cellular_componentGO:0045171 intercellular bridge IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Cleavage of Growing Transcript in the Termination Region
Transport of Mature mRNA derived from an Intron-Containing Transcript
mRNA 3-end processing


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ctsktm1Ypl/Ctsktm1Ypl
Genetic Background: 129S4/SvJae-Ctsktm1Ypl

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Ctsktm1Ypl/Ctsktm1Ypl
Genetic Background: 129S4/SvJae-Ctsktm1Ypl

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Ctsktm1Ypl/Ctsktm1Ypl
Genetic Background: 129S4/SvJae-Ctsktm1Ypl

Allelic Composition: Thoc1tm1Dwg/Thoc1tm2Dwg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctsktm1Ypl/Ctsktm1Ypl
Genetic Background: 129S4/SvJae-Ctsktm1Ypl

 MP:0003694 failure to hatch from the zona pellucida "the embryo fails to break out of the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation, may be seen in vivo or in cultured embryos" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0004964 absent inner cell mass "absence of the cells of the blastocyst that develop into the body of the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011093 complete embryonic lethality at implantation "death of all organisms of a given genotype in a population at the point of implantation (Mus: E4.5)" [MGI:csmith]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Ctsktm1Ypl/Ctsktm1Ypl
Genetic Background: 129S4/SvJae-Ctsktm1Ypl

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Thoc1tm1Dwg/Thoc1tm2Dwg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr