ENSMUSG00000024338


Mus musculus

Features
Gene ID: ENSMUSG00000024338
  
Biological name :Psmb8
  
Synonyms : P28063 / Proteasome subunit beta type-8 / Psmb8
  
Possible biological names infered from orthology : P28062 / proteasome subunit beta 8
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B1
Gene start: 34197721
Gene end: 34201454
  
Corresponding Affymetrix probe sets: 10444258 (MoGene1.0st)   1422962_a_at (Mouse Genome 430 2.0 Array)   1444619_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025196
Ensembl peptide - ENSMUSP00000134664
NCBI entrez gene - 16913     See in Manteia.
MGI - MGI:1346527
RefSeq - NM_010724
RefSeq Peptide - NP_034854
swissprot - G3UZW8
swissprot - P28063
Ensembl - ENSMUSG00000024338
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 psmb8aENSDARG00000001303Danio rerio
 PSMB8ENSG00000204264Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Psmb5 / O55234 / Proteasome subunit beta type-5 / P28074* / proteasome subunit beta 5*ENSMUSG0000002219357
Psmb11 / Q8BG41 / Proteasome subunit beta type-11 / A5LHX3* / proteasome subunit beta 11*ENSMUSG0000007242342


Protein motifs (from Interpro)
Interpro ID Name
 IPR000243  Peptidase T1A, proteasome beta-subunit
 IPR001353  Proteasome, subunit alpha/beta
 IPR016050  Proteasome beta-type subunit, conserved site
 IPR023333  Proteasome B-type subunit
 IPR029055  Nucleophile aminohydrolases, N-terminal
 IPR035705  Proteasome subunit beta type-8


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0019882 antigen processing and presentation IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0045444 fat cell differentiation IEA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IEA
 biological_processGO:0052548 regulation of endopeptidase activity IEA
 cellular_componentGO:0000502 proteasome complex ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005839 proteasome core complex IDA
 cellular_componentGO:0019774 proteasome core complex, beta-subunit complex ISS
 cellular_componentGO:1990111 spermatoproteasome complex IDA
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004298 threonine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog on state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Ubiquitin-dependent degradation of Cyclin D1
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001836 abnormal antigen presentation via MHC class I "anomaly in the process by which peptide, bound to major histocompatibility complex class I, is presented to lymphocytes at the surface of antigen presenting cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Psmb10tm1Mgro/Psmb10tm1Mgro,Psmb9/Psmb8tm1Klr/Psmb9/Psmb8tm1Klr
Genetic Background: B6.129-Psmb10tm1Mgro Psmb9/Psmb8tm1Klr

 MP:0001838 defective intracellular transport of class I molecules "impaired ability to move major histocompatibility complex class I molecules to the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgf9tm1.2Fwan/Fgf9tm1.2Fwan
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001841 decreased level of surface class I molecule "reduced expression of major histocompatibility complex class I molecules at the cell surface " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fgf9tm1.2Fwan/Fgf9tm1.2Fwan
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Psmb10tm1Mgro/Psmb10tm1Mgro,Psmb9/Psmb8tm1Klr/Psmb9/Psmb8tm1Klr
Genetic Background: B6.129-Psmb10tm1Mgro Psmb9/Psmb8tm1Klr

Allelic Composition: Psmb8tm1Hjf/Psmb8tm1Hjf
Genetic Background: involves: 129P2/OlaHsd

 MP:0002166 altered tumor susceptibility/resistance "greater than or less than the average number of tumors, usually a specific type, arising in a given strain when compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mecp2tm1Hzo/Mecp2+
Genetic Background: 129S7/SvEvBrd-Mecp2tm1Hzo

 MP:0002453 abnormal B lymphocyte antigen presentation "impairment in the ability of B lymphocyte to process and/or present antigen " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Psmb10tm1Mgro/Psmb10tm1Mgro,Psmb9/Psmb8tm1Klr/Psmb9/Psmb8tm1Klr
Genetic Background: B6.129-Psmb10tm1Mgro Psmb9/Psmb8tm1Klr

 MP:0002455 abnormal dendritic cell antigen presentation "impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Psmb10tm1Mgro/Psmb10tm1Mgro,Psmb9/Psmb8tm1Klr/Psmb9/Psmb8tm1Klr
Genetic Background: B6.129-Psmb10tm1Mgro Psmb9/Psmb8tm1Klr

Allelic Composition: Psmb8tm1Hjf/Psmb8tm1Hjf
Genetic Background: involves: 129P2/OlaHsd

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf9tm1.2Fwan/Fgf9tm1.2Fwan
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Psmb11tm1.1(Psmb8)Khog/Psmb11tm1.1(Psmb8)Khog,Psmb8tm1Hjf/Psmb8tm1Hjf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac

Allelic Composition: Psmb11tm1(Psmb8)Khog/Psmb11tm1(Psmb8)Khog,Psmb8tm1Hjf/Psmb8tm1Hjf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Psmb10tm1Mgro/Psmb10tm1Mgro,Psmb9/Psmb8tm1Klr/Psmb9/Psmb8tm1Klr
Genetic Background: B6.129-Psmb10tm1Mgro Psmb9/Psmb8tm1Klr

 MP:0008754 abnormal T cell receptor V(D)J recombination "any anomaly in the process by which T cell receptor V, D, and J, or V and J gene segments, depending on the specific locus, are recombined within a single locus" [GO:0033153, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Psmb11tm1.1(Psmb8)Khog/Psmb11tm1.1(Psmb8)Khog,Psmb8tm1Hjf/Psmb8tm1Hjf
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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