| MP:0000333 | decreased bone marrow cell number | "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896] |
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Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0000689 | abnormal spleen morphology | "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463] |
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Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0000692 | small spleen | "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0000694 | spleen hypoplasia | "small size due to reduced cell number in the spleen" [J:43971] |
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Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0000703 | abnormal thymus morphology | "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400] |
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Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0000780 | abnormal corpus callosum morphology | "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0000781 | reduced size of corpus callosum | "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857] |
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Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0000849 | abnormal cerebellum morphology | "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0001263 | weight loss | "progressive reduction of body weight below normal average for age" [J:45400] |
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Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0001405 | impaired coordination | "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0001823 | thymus hypoplasia | "small size due to reduced cell number in the thymus" [J:23255] |
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Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0001828 | abnormal T cell activation | "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0001872 | sinus inflammation | "increase in susceptibility of the hollow cavities in bone (usually but not exclusively those in the skull) to allergens and/or pathogens" [MGI:tc, J:60896] |
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Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0001891 | hydroencephaly | "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
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Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0002144 | abnormal B lymphocyte development | "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0002199 | abnormal brain commissure morphology | "absent or defective structure in a bundle of nerve fibers connecting the two brain hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0002356 | abnormal spleen red pulp morphology | "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0] |
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Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0002357 | abnormal spleen white pulp morphology | "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0002447 | abnormal erythrocyte morphology | "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0002875 | decreased erythrocyte count | "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0004939 | abnormal B cell morphology | "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0004956 | decreased thymus weight | "reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0004978 | decreased B-1 B cell number | "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0005065 | abnormal neutrophil morphology | "structural anomaly of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0008026 | abnormal brain white matter morphology | "any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0008207 | decreased B-2 cell number | "reduced number of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604] |
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Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0008209 | decreased pre-B cell number | "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0008217 | abnormal B cell activation | "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0008489 | postnatal slow weight gain | "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0008826 | abnormal splenic cell ratio | "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"] |
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Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0008827 | abnormal thymus cell ratio | "deviation from the standard ratios of thymocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"] |
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Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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| MP:0009703 | decreased birth body size | "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bcl2l1tm1Ywh/Bcl2l1tm1Ywh,Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
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