ENSMUSG00000024378


Mus musculus

Features
Gene ID: ENSMUSG00000024378
  
Biological name :Stard4
  
Synonyms : Stard4 / StAR-related lipid transfer (START) domain containing 4
  
Possible biological names infered from orthology : Q96DR4 / StAR related lipid transfer domain containing 4
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: B1
Gene start: 33199355
Gene end: 33213862
  
Corresponding Affymetrix probe sets: 10458033 (MoGene1.0st)   1429239_a_at (Mouse Genome 430 2.0 Array)   1429240_at (Mouse Genome 430 2.0 Array)   1455011_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114109
Ensembl peptide - ENSMUSP00000114131
Ensembl peptide - ENSMUSP00000025236
NCBI entrez gene - 170459     See in Manteia.
MGI - MGI:2156764
RefSeq - NM_133774
RefSeq - XM_006525694
RefSeq Peptide - NP_001334553
RefSeq Peptide - NP_598535
swissprot - D3YW24
swissprot - Q80SX0
swissprot - D3YW30
Ensembl - ENSMUSG00000024378
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stard4ENSDARG00000102477Danio rerio
 STARD4ENSGALG00000000241Gallus gallus
 Q96DR4ENSG00000164211Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9EPQ7 / Stard5 / StAR-related lipid transfer (START) domain containing 5 / Q9NSY2* / StAR related lipid transfer domain containing 5*ENSMUSG0000004602732
P59096 / Stard6 / StAR-related lipid transfer protein 6 / P59095* / StAR related lipid transfer domain containing 6*ENSMUSG0000007960824


Protein motifs (from Interpro)
Interpro ID Name
 IPR002913  START domain
 IPR023393  START-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010873 positive regulation of cholesterol esterification IEA
 biological_processGO:0010879 cholesterol transport involved in cholesterol storage IEA
 biological_processGO:0032367 intracellular cholesterol transport IEA
 biological_processGO:0070508 cholesterol import IEA
 biological_processGO:0070859 positive regulation of bile acid biosynthetic process IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0015485 cholesterol binding IEA
 molecular_functionGO:0017127 cholesterol transporter activity IEA


Pathways (from Reactome)
Pathway description
Pregnenolone biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Trp53tm1Holl/Trp53tm7.1Xu
Genetic Background: involves: 129P2/OlaHsd

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1Holl/Trp53tm7.1Xu
Genetic Background: involves: 129P2/OlaHsd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Trp53tm1Holl/Trp53tm7.1Xu
Genetic Background: involves: 129P2/OlaHsd

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1Holl/Trp53tm7.1Xu
Genetic Background: involves: 129P2/OlaHsd

 MP:0004773 abnormal bile composition "any alteration in the chemical make up of the greenish-yellow fluid secreted by the liver; normally contains bile acids and salts such as sodium glycocholate and sodium taurocholate as well as cholesterol, biliverdin and bilirubin, mucus, fat, lecithin, and cells and cellular debris" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53tm1Holl/Trp53tm7.1Xu
Genetic Background: involves: 129P2/OlaHsd

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trp53tm1Holl/Trp53tm7.1Xu
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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